Heart failure, oxidative stress and allopurinol
Oxidative stress is one of the new and most intriguing pathogenetic hypotheses of heart failure; it involves various mechanisms such as endothelial dysfunction, mechanoenergetic uncoupling and apoptosis. Xanthine oxidase, a key enzyme in purine catabolism, is overexpressed in patients with heart fai...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2005-03-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/609 |
| _version_ | 1818844521434185728 |
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| author | Paolo Biagi Luigi Abate |
| author_facet | Paolo Biagi Luigi Abate |
| author_sort | Paolo Biagi |
| collection | DOAJ |
| description | Oxidative stress is one of the new and most intriguing pathogenetic hypotheses of heart failure; it involves various mechanisms such as endothelial dysfunction, mechanoenergetic uncoupling and apoptosis. Xanthine oxidase, a key enzyme in purine catabolism, is overexpressed in patients with heart failure, and it is also an important source of oxidizing activity molecules (free radicals, superoxide anion, oxygen peroxide, etc…). Allopurinol competitively inhibits the action of xanthine oxidase and effectively counters oxidative stress. It could thus prove useful in the treatment of heart failure: in fact it is the only drug that has been proven able to lower O2 consumption of dysfunctioning myocardium. The Authors briefly review the xanthine oxido-reductase enzyme system and in particular analyse the latest evidence reported in the literature on allopurinol in the treatment of heart failure. |
| first_indexed | 2024-12-19T05:15:05Z |
| format | Article |
| id | doaj.art-8aeced1e8aab4587bdb695f638c42159 |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-12-19T05:15:05Z |
| publishDate | 2005-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-8aeced1e8aab4587bdb695f638c421592022-12-21T20:34:42ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642005-03-0164110.4081/monaldi.2005.609Heart failure, oxidative stress and allopurinolPaolo Biagi0Luigi Abate1Unità Funzionale di Medicina Interna, Ospedali Riuniti della Val di Chiana Senese, Montepulciano (SI)Unità Funzionale di Medicina Interna, Ospedali Riuniti della Val di Chiana Senese, Montepulciano (SI)Oxidative stress is one of the new and most intriguing pathogenetic hypotheses of heart failure; it involves various mechanisms such as endothelial dysfunction, mechanoenergetic uncoupling and apoptosis. Xanthine oxidase, a key enzyme in purine catabolism, is overexpressed in patients with heart failure, and it is also an important source of oxidizing activity molecules (free radicals, superoxide anion, oxygen peroxide, etc…). Allopurinol competitively inhibits the action of xanthine oxidase and effectively counters oxidative stress. It could thus prove useful in the treatment of heart failure: in fact it is the only drug that has been proven able to lower O2 consumption of dysfunctioning myocardium. The Authors briefly review the xanthine oxido-reductase enzyme system and in particular analyse the latest evidence reported in the literature on allopurinol in the treatment of heart failure.https://www.monaldi-archives.org/index.php/macd/article/view/609heart failureuric acidoxidative stressallopurinol |
| spellingShingle | Paolo Biagi Luigi Abate Heart failure, oxidative stress and allopurinol Monaldi Archives for Chest Disease heart failure uric acid oxidative stress allopurinol |
| title | Heart failure, oxidative stress and allopurinol |
| title_full | Heart failure, oxidative stress and allopurinol |
| title_fullStr | Heart failure, oxidative stress and allopurinol |
| title_full_unstemmed | Heart failure, oxidative stress and allopurinol |
| title_short | Heart failure, oxidative stress and allopurinol |
| title_sort | heart failure oxidative stress and allopurinol |
| topic | heart failure uric acid oxidative stress allopurinol |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/609 |
| work_keys_str_mv | AT paolobiagi heartfailureoxidativestressandallopurinol AT luigiabate heartfailureoxidativestressandallopurinol |