Place of pegylated liposomal doxorubicin in the therapy of metastatic breast cancer
The review deals with trials of pegylated liposomal doxorubicin (PLD) used to treat metastatic breast cancer (mBC), including first-line monotherapy, maintenance therapy, combinations with other cytostatics, trastuzumab regimens for a HER-2-positive subvariant, and rescue therapy for intensively pre...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2016-09-01
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| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/492 |
| _version_ | 1826557283461496832 |
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| author | E. V. Artamonova |
| author_facet | E. V. Artamonova |
| author_sort | E. V. Artamonova |
| collection | DOAJ |
| description | The review deals with trials of pegylated liposomal doxorubicin (PLD) used to treat metastatic breast cancer (mBC), including first-line monotherapy, maintenance therapy, combinations with other cytostatics, trastuzumab regimens for a HER-2-positive subvariant, and rescue therapy for intensively pretreated forms of the disease. PLD is shown to be highly competitive with conventional anthracyclines in efficacy and to greatly surpass them in safety particularly in patients at high cardiac risk; the lack of cumulative toxicity and maximum allowable dose makes it possible to perform therapy until the disease progresses, to use the drug as a support, and to effectively and safely combine PLD with trastuzumab in HER-2-positive mBC. A clinical benefit from the administration of PLD does not depend on susceptibility to anthracyclines. The drug is also an important treatment option for taxane-refractory mBC. |
| first_indexed | 2024-04-10T01:56:36Z |
| format | Article |
| id | doaj.art-8aede936c31b4c91b5296f73fd282695 |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2025-03-14T08:26:08Z |
| publishDate | 2016-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-8aede936c31b4c91b5296f73fd2826952025-03-02T13:05:33ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272016-09-01122354510.17650/1994-4098-2016-12-2-35-45497Place of pegylated liposomal doxorubicin in the therapy of metastatic breast cancerE. V. Artamonova0N.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaThe review deals with trials of pegylated liposomal doxorubicin (PLD) used to treat metastatic breast cancer (mBC), including first-line monotherapy, maintenance therapy, combinations with other cytostatics, trastuzumab regimens for a HER-2-positive subvariant, and rescue therapy for intensively pretreated forms of the disease. PLD is shown to be highly competitive with conventional anthracyclines in efficacy and to greatly surpass them in safety particularly in patients at high cardiac risk; the lack of cumulative toxicity and maximum allowable dose makes it possible to perform therapy until the disease progresses, to use the drug as a support, and to effectively and safely combine PLD with trastuzumab in HER-2-positive mBC. A clinical benefit from the administration of PLD does not depend on susceptibility to anthracyclines. The drug is also an important treatment option for taxane-refractory mBC.https://ojrs.abvpress.ru/ojrs/article/view/492metastatic breast canceranthracyclinespegylated liposomal doxorubicin |
| spellingShingle | E. V. Artamonova Place of pegylated liposomal doxorubicin in the therapy of metastatic breast cancer Опухоли женской репродуктивной системы metastatic breast cancer anthracyclines pegylated liposomal doxorubicin |
| title | Place of pegylated liposomal doxorubicin in the therapy of metastatic breast cancer |
| title_full | Place of pegylated liposomal doxorubicin in the therapy of metastatic breast cancer |
| title_fullStr | Place of pegylated liposomal doxorubicin in the therapy of metastatic breast cancer |
| title_full_unstemmed | Place of pegylated liposomal doxorubicin in the therapy of metastatic breast cancer |
| title_short | Place of pegylated liposomal doxorubicin in the therapy of metastatic breast cancer |
| title_sort | place of pegylated liposomal doxorubicin in the therapy of metastatic breast cancer |
| topic | metastatic breast cancer anthracyclines pegylated liposomal doxorubicin |
| url | https://ojrs.abvpress.ru/ojrs/article/view/492 |
| work_keys_str_mv | AT evartamonova placeofpegylatedliposomaldoxorubicininthetherapyofmetastaticbreastcancer |