TOM40 Inhibits Ovarian Cancer Cell Growth by Modulating Mitochondrial Function Including Intracellular ATP and ROS Levels

TOM40 Inhibits Ovarian Cancer Cell Growth by Modulating Mitochondrial Function Including Intracellular ATP and ROS Levels

TOM40 is a channel-forming subunit of translocase, which is essential for the movement of proteins into the mitochondria. We found that TOM40 was highly expressed in epithelial ovarian cancer (EOC) cells at both the transcriptional and translational levels; its expression increased significantly dur...

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Bibliographic Details
Main Authors: Wookyeom Yang, Ha-Yeon Shin, Hanbyoul Cho, Joon-Yong Chung, Eun-ju Lee, Jae-Hoon Kim, Eun-Suk Kang
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
TOM40
epithelial ovarian cancer
mitochondria
metformin
Online Access:https://www.mdpi.com/2072-6694/12/5/1329

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