Ellipsoid clustering machine: a front line to aid in disease diagnosis - DOI: 10.3395/reciis.v1i2.Sup.101en
This study presents a new machine learning strategy to address the disease diagnosis classification problem that comprises an unknown number of disease classes. This is exemplified by a software called Ellipsoid Clustering Machine (ECM) that identifies conserved regions in mass spectrometry proteomi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Instituto de Comunicação e Informação Científica e Tecnológica em Saúde (Icict) da Fundação Oswaldo Cruz (Fiocruz)
2007-12-01
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| Series: | RECIIS |
| Subjects: | |
| Online Access: | http://www.reciis.cict.fiocruz.br/index.php/reciis/article/view/101/114 |
| _version_ | 1818416044411191296 |
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| author | Paulo Costa Carvalho Juliana de Saldanha da Gama Fischer Valmir C. Barbosa Maria da Glória da Costa Carvalho Wim Degrave Gilberto Barbosa Domont |
| author_facet | Paulo Costa Carvalho Juliana de Saldanha da Gama Fischer Valmir C. Barbosa Maria da Glória da Costa Carvalho Wim Degrave Gilberto Barbosa Domont |
| author_sort | Paulo Costa Carvalho |
| collection | DOAJ |
| description | This study presents a new machine learning strategy to address the disease diagnosis classification problem that comprises an unknown number of disease classes. This is exemplified by a software called Ellipsoid Clustering Machine (ECM) that identifies conserved regions in mass spectrometry proteomic profiles obtained from control subjects and uses these to estimate classification boundaries based on sample variance. The software can also be used for visual inspection of data reproducibility. ECM was evaluated using mass spectrometry protein profiles obtained from serum of Hodgkin’s disease patients (HD) and control subjects. According to the leave-one-out cross validation, ECM completely separated both groups based only on the information derived from four selected mass spectral peaks. Classification details and a 3D graphical model showing the separation between the control subject cluster and HD patients is also presented. The software is available on the project website together with online interactive models of the dataset and an animation demonstrating the method. |
| first_indexed | 2024-12-14T11:44:38Z |
| format | Article |
| id | doaj.art-8af1f7a1146f407b9a74fa81a1edc9b4 |
| institution | Directory Open Access Journal |
| issn | 1981-6278 |
| language | English |
| last_indexed | 2024-12-14T11:44:38Z |
| publishDate | 2007-12-01 |
| publisher | Instituto de Comunicação e Informação Científica e Tecnológica em Saúde (Icict) da Fundação Oswaldo Cruz (Fiocruz) |
| record_format | Article |
| series | RECIIS |
| spelling | doaj.art-8af1f7a1146f407b9a74fa81a1edc9b42022-12-21T23:02:41ZengInstituto de Comunicação e Informação Científica e Tecnológica em Saúde (Icict) da Fundação Oswaldo Cruz (Fiocruz)RECIIS1981-62782007-12-0112Sup308Sup315Ellipsoid clustering machine: a front line to aid in disease diagnosis - DOI: 10.3395/reciis.v1i2.Sup.101enPaulo Costa CarvalhoJuliana de Saldanha da Gama FischerValmir C. BarbosaMaria da Glória da Costa CarvalhoWim DegraveGilberto Barbosa DomontThis study presents a new machine learning strategy to address the disease diagnosis classification problem that comprises an unknown number of disease classes. This is exemplified by a software called Ellipsoid Clustering Machine (ECM) that identifies conserved regions in mass spectrometry proteomic profiles obtained from control subjects and uses these to estimate classification boundaries based on sample variance. The software can also be used for visual inspection of data reproducibility. ECM was evaluated using mass spectrometry protein profiles obtained from serum of Hodgkin’s disease patients (HD) and control subjects. According to the leave-one-out cross validation, ECM completely separated both groups based only on the information derived from four selected mass spectral peaks. Classification details and a 3D graphical model showing the separation between the control subject cluster and HD patients is also presented. The software is available on the project website together with online interactive models of the dataset and an animation demonstrating the method.http://www.reciis.cict.fiocruz.br/index.php/reciis/article/view/101/114Mass spectrometrymachine learningpattern recognitionclusteringHodgkin’s diseaseproteomics |
| spellingShingle | Paulo Costa Carvalho Juliana de Saldanha da Gama Fischer Valmir C. Barbosa Maria da Glória da Costa Carvalho Wim Degrave Gilberto Barbosa Domont Ellipsoid clustering machine: a front line to aid in disease diagnosis - DOI: 10.3395/reciis.v1i2.Sup.101en RECIIS Mass spectrometry machine learning pattern recognition clustering Hodgkin’s disease proteomics |
| title | Ellipsoid clustering machine: a front line to aid in disease diagnosis - DOI: 10.3395/reciis.v1i2.Sup.101en |
| title_full | Ellipsoid clustering machine: a front line to aid in disease diagnosis - DOI: 10.3395/reciis.v1i2.Sup.101en |
| title_fullStr | Ellipsoid clustering machine: a front line to aid in disease diagnosis - DOI: 10.3395/reciis.v1i2.Sup.101en |
| title_full_unstemmed | Ellipsoid clustering machine: a front line to aid in disease diagnosis - DOI: 10.3395/reciis.v1i2.Sup.101en |
| title_short | Ellipsoid clustering machine: a front line to aid in disease diagnosis - DOI: 10.3395/reciis.v1i2.Sup.101en |
| title_sort | ellipsoid clustering machine a front line to aid in disease diagnosis doi 10 3395 reciis v1i2 sup 101en |
| topic | Mass spectrometry machine learning pattern recognition clustering Hodgkin’s disease proteomics |
| url | http://www.reciis.cict.fiocruz.br/index.php/reciis/article/view/101/114 |
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