Use of a novel “Split” ventilation system in bench and porcine modeling of acute respiratory distress syndrome
Abstract Split ventilation (using a single ventilator to ventilate multiple patients) is technically feasible. However, connecting two patients with acute respiratory distress syndrome (ARDS) and differing lung mechanics to a single ventilator is concerning. This study aimed to: (1) determine functi...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.15452 |
| _version_ | 1797397152311279616 |
|---|---|
| author | Pierce Geoghegan Jennifer Clarke Grace Hogan Aoife Keogh Hannah Marsh Karen Donnelly Natalie McEvoy Aoife Doolan Stephen F. Madden Ignacio Martin‐Loeches Michael Power John G. Laffey Gerard F. Curley |
| author_facet | Pierce Geoghegan Jennifer Clarke Grace Hogan Aoife Keogh Hannah Marsh Karen Donnelly Natalie McEvoy Aoife Doolan Stephen F. Madden Ignacio Martin‐Loeches Michael Power John G. Laffey Gerard F. Curley |
| author_sort | Pierce Geoghegan |
| collection | DOAJ |
| description | Abstract Split ventilation (using a single ventilator to ventilate multiple patients) is technically feasible. However, connecting two patients with acute respiratory distress syndrome (ARDS) and differing lung mechanics to a single ventilator is concerning. This study aimed to: (1) determine functionality of a split ventilation system in benchtop tests, (2) determine whether standard ventilation would be superior to split ventilation in a porcine model of ARDS and (3) assess usability of a split ventilation system with minimal specific training. The functionality of a split ventilation system was assessed using test lungs. The usability of the system was assessed in simulated clinical scenarios. The feasibility of the system to provide modified lung protective ventilation was assessed in a porcine model of ARDS (n = 30). In bench testing a split ventilation system independently ventilated two test lungs under conditions of varying compliance and resistance. In usability tests, a high proportion of naïve operators could assemble and use the system. In the porcine model, modified lung protective ventilation was feasible with split ventilation and produced similar respiratory mechanics, gas exchange and biomarkers of lung injury when compared to standard ventilation. Split ventilation can provide some elements of lung protective ventilation and is feasible in bench testing and an in vivo model of ARDS. |
| first_indexed | 2024-03-09T01:05:48Z |
| format | Article |
| id | doaj.art-8af2340459a0475e9a04c2002b81338c |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-09T01:05:48Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-8af2340459a0475e9a04c2002b81338c2023-12-11T09:36:43ZengWileyPhysiological Reports2051-817X2022-09-011017n/an/a10.14814/phy2.15452Use of a novel “Split” ventilation system in bench and porcine modeling of acute respiratory distress syndromePierce Geoghegan0Jennifer Clarke1Grace Hogan2Aoife Keogh3Hannah Marsh4Karen Donnelly5Natalie McEvoy6Aoife Doolan7Stephen F. Madden8Ignacio Martin‐Loeches9Michael Power10John G. Laffey11Gerard F. Curley12Department of Anaesthesia and Critical Care Royal College of Surgeons in Ireland Dublin IrelandDepartment of Anaesthesia and Critical Care Royal College of Surgeons in Ireland Dublin IrelandDepartment of Anaesthesia and Critical Care Royal College of Surgeons in Ireland Dublin IrelandDepartment of Anaesthesia and Critical Care Royal College of Surgeons in Ireland Dublin IrelandBeaumont Hospital Dublin IrelandDepartment of Anaesthesia and Critical Care Royal College of Surgeons in Ireland Dublin IrelandDepartment of Anaesthesia and Critical Care Royal College of Surgeons in Ireland Dublin IrelandTallaght Hospital Dublin IrelandData Science Centre Royal College of Surgeons in Ireland Dublin IrelandDepartment of Intensive Care St. James Hospital Dublin IrelandBeaumont Hospital Dublin IrelandDepartment of Anaesthesia and Critical Care Galway University Hospital Galway IrelandDepartment of Anaesthesia and Critical Care Royal College of Surgeons in Ireland Dublin IrelandAbstract Split ventilation (using a single ventilator to ventilate multiple patients) is technically feasible. However, connecting two patients with acute respiratory distress syndrome (ARDS) and differing lung mechanics to a single ventilator is concerning. This study aimed to: (1) determine functionality of a split ventilation system in benchtop tests, (2) determine whether standard ventilation would be superior to split ventilation in a porcine model of ARDS and (3) assess usability of a split ventilation system with minimal specific training. The functionality of a split ventilation system was assessed using test lungs. The usability of the system was assessed in simulated clinical scenarios. The feasibility of the system to provide modified lung protective ventilation was assessed in a porcine model of ARDS (n = 30). In bench testing a split ventilation system independently ventilated two test lungs under conditions of varying compliance and resistance. In usability tests, a high proportion of naïve operators could assemble and use the system. In the porcine model, modified lung protective ventilation was feasible with split ventilation and produced similar respiratory mechanics, gas exchange and biomarkers of lung injury when compared to standard ventilation. Split ventilation can provide some elements of lung protective ventilation and is feasible in bench testing and an in vivo model of ARDS.https://doi.org/10.14814/phy2.15452acute lung injuryacute respiratory distress syndromelung protective ventilationsplit ventilation |
| spellingShingle | Pierce Geoghegan Jennifer Clarke Grace Hogan Aoife Keogh Hannah Marsh Karen Donnelly Natalie McEvoy Aoife Doolan Stephen F. Madden Ignacio Martin‐Loeches Michael Power John G. Laffey Gerard F. Curley Use of a novel “Split” ventilation system in bench and porcine modeling of acute respiratory distress syndrome Physiological Reports acute lung injury acute respiratory distress syndrome lung protective ventilation split ventilation |
| title | Use of a novel “Split” ventilation system in bench and porcine modeling of acute respiratory distress syndrome |
| title_full | Use of a novel “Split” ventilation system in bench and porcine modeling of acute respiratory distress syndrome |
| title_fullStr | Use of a novel “Split” ventilation system in bench and porcine modeling of acute respiratory distress syndrome |
| title_full_unstemmed | Use of a novel “Split” ventilation system in bench and porcine modeling of acute respiratory distress syndrome |
| title_short | Use of a novel “Split” ventilation system in bench and porcine modeling of acute respiratory distress syndrome |
| title_sort | use of a novel split ventilation system in bench and porcine modeling of acute respiratory distress syndrome |
| topic | acute lung injury acute respiratory distress syndrome lung protective ventilation split ventilation |
| url | https://doi.org/10.14814/phy2.15452 |
| work_keys_str_mv | AT piercegeoghegan useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT jenniferclarke useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT gracehogan useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT aoifekeogh useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT hannahmarsh useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT karendonnelly useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT nataliemcevoy useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT aoifedoolan useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT stephenfmadden useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT ignaciomartinloeches useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT michaelpower useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT johnglaffey useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome AT gerardfcurley useofanovelsplitventilationsysteminbenchandporcinemodelingofacuterespiratorydistresssyndrome |