Coffee and the Risk of Lymphoma: A Meta-analysis Article
Background: Coffee is implicated in the susceptibility to several cancers. However, the association between coffee and lymphoma remains unclear. This meta-analysis aimed to assess quantitatively the association between coffee and the incidence of lymphoma. Methods: A literature search was performed...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2016-10-01
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| Series: | Iranian Journal of Public Health |
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| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/7848 |
| _version_ | 1818787939900981248 |
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| author | Tianjie HAN Junshan LI Ling WANG Hongzhi XU |
| author_facet | Tianjie HAN Junshan LI Ling WANG Hongzhi XU |
| author_sort | Tianjie HAN |
| collection | DOAJ |
| description | Background: Coffee is implicated in the susceptibility to several cancers. However, the association between coffee and lymphoma remains unclear. This meta-analysis aimed to assess quantitatively the association between coffee and the incidence of lymphoma.
Methods: A literature search was performed for cohort and case-control studies published using PubMed, Cochrane, and EMBASE databases. Studies were included if they reported relative ratios (RR) and corresponding 95% confidence intervals (CIs) of lymphoma with respect to coffee consumption. Pooled relative risk (RR) and its 95% confidence interval (CI) were calculated. All P values are two tailed
Results: Seven studies met the inclusion criteria, which included three cohort and four case-control studies. Compared with did not or seldom drink coffee per day, being no significantly association between coffee and risk of lymphoma (pooled RR: 1.05, 95%CI: 0.89-1.23). In the subgroup analysis, no significant association between coffee and lymphoma risk was detected not only in different study types (cohort studies RR: 1.29; 95% CI, 0.92-1.80; case control studies RR: 0.99; 95% CI, 0.82-1.99) but also in different regions (Europe RR: 1.21; 95% CI: 0.99-1.47; USA RR: 0.85; 95% CI, 0.62-1.15; Asia RR: 1.08, 95% CI: 0.84-1.40) and coffee consumption status (≥4cups/d 1.03, 95% CI: 0.69–1.56; ＜4cups/d RR: 1.06, 95% CI: 0.89- 1.26 ). The funnel plot revealed no evidence for publication bias.
Conclusion: There was no sufficient evidence to support coffee consumption association with the risk of lymphoma. Further well-designed large-scaled cohort studies are needed to provide conclusions that are more definitive. |
| first_indexed | 2024-12-18T14:15:45Z |
| format | Article |
| id | doaj.art-8af3b07699b64d288b4b69305d7b101c |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-18T14:15:45Z |
| publishDate | 2016-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-8af3b07699b64d288b4b69305d7b101c2022-12-21T21:05:00ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932016-10-014594997Coffee and the Risk of Lymphoma: A Meta-analysis ArticleTianjie HAN0Junshan LI1Ling WANG2Hongzhi XU3Dept. of Hematology, Tai’an Central Hospital, Tai’an, Shandong, ChinaDept. of Gastroenterology, Tai’an Central Hospital, Tai’an, Shandong, ChinaDept. of Hematology, Tai’an Central Hospital, Tai’an, Shandong, ChinaDept. of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, ChinaBackground: Coffee is implicated in the susceptibility to several cancers. However, the association between coffee and lymphoma remains unclear. This meta-analysis aimed to assess quantitatively the association between coffee and the incidence of lymphoma. Methods: A literature search was performed for cohort and case-control studies published using PubMed, Cochrane, and EMBASE databases. Studies were included if they reported relative ratios (RR) and corresponding 95% confidence intervals (CIs) of lymphoma with respect to coffee consumption. Pooled relative risk (RR) and its 95% confidence interval (CI) were calculated. All P values are two tailed Results: Seven studies met the inclusion criteria, which included three cohort and four case-control studies. Compared with did not or seldom drink coffee per day, being no significantly association between coffee and risk of lymphoma (pooled RR: 1.05, 95%CI: 0.89-1.23). In the subgroup analysis, no significant association between coffee and lymphoma risk was detected not only in different study types (cohort studies RR: 1.29; 95% CI, 0.92-1.80; case control studies RR: 0.99; 95% CI, 0.82-1.99) but also in different regions (Europe RR: 1.21; 95% CI: 0.99-1.47; USA RR: 0.85; 95% CI, 0.62-1.15; Asia RR: 1.08, 95% CI: 0.84-1.40) and coffee consumption status (≥4cups/d 1.03, 95% CI: 0.69–1.56; ＜4cups/d RR: 1.06, 95% CI: 0.89- 1.26 ). The funnel plot revealed no evidence for publication bias. Conclusion: There was no sufficient evidence to support coffee consumption association with the risk of lymphoma. Further well-designed large-scaled cohort studies are needed to provide conclusions that are more definitive.https://ijph.tums.ac.ir/index.php/ijph/article/view/7848LymphomaCoffeeCohort studyCase-control studyMeta-analysis |
| spellingShingle | Tianjie HAN Junshan LI Ling WANG Hongzhi XU Coffee and the Risk of Lymphoma: A Meta-analysis Article Iranian Journal of Public Health Lymphoma Coffee Cohort study Case-control study Meta-analysis |
| title | Coffee and the Risk of Lymphoma: A Meta-analysis Article |
| title_full | Coffee and the Risk of Lymphoma: A Meta-analysis Article |
| title_fullStr | Coffee and the Risk of Lymphoma: A Meta-analysis Article |
| title_full_unstemmed | Coffee and the Risk of Lymphoma: A Meta-analysis Article |
| title_short | Coffee and the Risk of Lymphoma: A Meta-analysis Article |
| title_sort | coffee and the risk of lymphoma a meta analysis article |
| topic | Lymphoma Coffee Cohort study Case-control study Meta-analysis |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/7848 |
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