Dry Extract of Passiflora incarnata L. leaves as a Cardiac and Hepatic Oxidative Stress Protector in LDLr-/- Mice Fed High-Fat Diet
ABSTRACT The control of dyslipidemia by using herbal products is an important subject for studies. In this study, we evaluated the effects of dry Passiflora incarnata L. extract over dyslipidemia, left ventricular hypertrophy, and hepatic oxidative stress of LDL receptor knockout mice (LDLr-/-). For...
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| Format: | Article |
| Language: | English |
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Instituto de Tecnologia do Paraná (Tecpar)
2018-11-01
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| Series: | Brazilian Archives of Biology and Technology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100321&lng=en&tlng=en |
| _version_ | 1818209041440047104 |
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| author | Danielle Aparecida Quintino Silva Sarto Ana Helena D’Arcadia de Siqueira Francisco Monteiro de Almeida Magalhaes Karine de Paula Caproni Ângela Maria Martins Gérsika Bitencourt Santos Délcio Bueno da Silva Brígida Monteiro Vilas Boas José Antônio Dias Garcia |
| author_facet | Danielle Aparecida Quintino Silva Sarto Ana Helena D’Arcadia de Siqueira Francisco Monteiro de Almeida Magalhaes Karine de Paula Caproni Ângela Maria Martins Gérsika Bitencourt Santos Délcio Bueno da Silva Brígida Monteiro Vilas Boas José Antônio Dias Garcia |
| author_sort | Danielle Aparecida Quintino Silva Sarto |
| collection | DOAJ |
| description | ABSTRACT The control of dyslipidemia by using herbal products is an important subject for studies. In this study, we evaluated the effects of dry Passiflora incarnata L. extract over dyslipidemia, left ventricular hypertrophy, and hepatic oxidative stress of LDL receptor knockout mice (LDLr-/-). Forty 4-month old male LDLr-/- mice were distributed into four groups: Group standard diet; Group standard diet and 200 mg/kg of body weight of Passiflora incarnata L. leaf dry extract; Group high-fat diet; Group high-fat diet and 200 mg/kg of body weight of Passiflora incarnata L. leaf dry extract. After 30 days, Passiflora incarnata L. dry extract reduced the effects of the high-fat diet, with a decrease of total cholesterol, triglycerides, and increase of high-density lipoprotein (HDL), as well as a reduction of C-reactive protein, alkaline phosphatase and insulin. There was no effect on glucose, Homa index and enzymes aspartate aminotransferase and alanine aminotransferase. However, the prevention of left ventricular hypertrophy occurred, as well as lipid peroxidation and the production of carbonyl proteins, which are both oxidative stress markers. In conclusion, Passiflora incarnata L. dry extract acts in the prevention of dyslipidemia, consequently, hindering the occurrence of hepatic oxidative stress and the development of left ventricular hypertrophy by the increase of serum HDL, in mice that had the effects of a high-fat diet. |
| first_indexed | 2024-12-12T04:54:24Z |
| format | Article |
| id | doaj.art-8af429a5e7b84b08b299bf543572758e |
| institution | Directory Open Access Journal |
| issn | 1678-4324 |
| language | English |
| last_indexed | 2024-12-12T04:54:24Z |
| publishDate | 2018-11-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-8af429a5e7b84b08b299bf543572758e2022-12-22T00:37:24ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43242018-11-0161010.1590/1678-4324-2018180147S1516-89132018000100321Dry Extract of Passiflora incarnata L. leaves as a Cardiac and Hepatic Oxidative Stress Protector in LDLr-/- Mice Fed High-Fat DietDanielle Aparecida Quintino Silva SartoAna Helena D’Arcadia de SiqueiraFrancisco Monteiro de Almeida MagalhaesKarine de Paula CaproniÂngela Maria MartinsGérsika Bitencourt SantosDélcio Bueno da SilvaBrígida Monteiro Vilas BoasJosé Antônio Dias GarciaABSTRACT The control of dyslipidemia by using herbal products is an important subject for studies. In this study, we evaluated the effects of dry Passiflora incarnata L. extract over dyslipidemia, left ventricular hypertrophy, and hepatic oxidative stress of LDL receptor knockout mice (LDLr-/-). Forty 4-month old male LDLr-/- mice were distributed into four groups: Group standard diet; Group standard diet and 200 mg/kg of body weight of Passiflora incarnata L. leaf dry extract; Group high-fat diet; Group high-fat diet and 200 mg/kg of body weight of Passiflora incarnata L. leaf dry extract. After 30 days, Passiflora incarnata L. dry extract reduced the effects of the high-fat diet, with a decrease of total cholesterol, triglycerides, and increase of high-density lipoprotein (HDL), as well as a reduction of C-reactive protein, alkaline phosphatase and insulin. There was no effect on glucose, Homa index and enzymes aspartate aminotransferase and alanine aminotransferase. However, the prevention of left ventricular hypertrophy occurred, as well as lipid peroxidation and the production of carbonyl proteins, which are both oxidative stress markers. In conclusion, Passiflora incarnata L. dry extract acts in the prevention of dyslipidemia, consequently, hindering the occurrence of hepatic oxidative stress and the development of left ventricular hypertrophy by the increase of serum HDL, in mice that had the effects of a high-fat diet.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100321&lng=en&tlng=enPassion fruitleft ventricular hypertrophydyslipidemiaoxidative stress |
| spellingShingle | Danielle Aparecida Quintino Silva Sarto Ana Helena D’Arcadia de Siqueira Francisco Monteiro de Almeida Magalhaes Karine de Paula Caproni Ângela Maria Martins Gérsika Bitencourt Santos Délcio Bueno da Silva Brígida Monteiro Vilas Boas José Antônio Dias Garcia Dry Extract of Passiflora incarnata L. leaves as a Cardiac and Hepatic Oxidative Stress Protector in LDLr-/- Mice Fed High-Fat Diet Brazilian Archives of Biology and Technology Passion fruit left ventricular hypertrophy dyslipidemia oxidative stress |
| title | Dry Extract of Passiflora incarnata L. leaves as a Cardiac and Hepatic Oxidative Stress Protector in LDLr-/- Mice Fed High-Fat Diet |
| title_full | Dry Extract of Passiflora incarnata L. leaves as a Cardiac and Hepatic Oxidative Stress Protector in LDLr-/- Mice Fed High-Fat Diet |
| title_fullStr | Dry Extract of Passiflora incarnata L. leaves as a Cardiac and Hepatic Oxidative Stress Protector in LDLr-/- Mice Fed High-Fat Diet |
| title_full_unstemmed | Dry Extract of Passiflora incarnata L. leaves as a Cardiac and Hepatic Oxidative Stress Protector in LDLr-/- Mice Fed High-Fat Diet |
| title_short | Dry Extract of Passiflora incarnata L. leaves as a Cardiac and Hepatic Oxidative Stress Protector in LDLr-/- Mice Fed High-Fat Diet |
| title_sort | dry extract of passiflora incarnata l leaves as a cardiac and hepatic oxidative stress protector in ldlr mice fed high fat diet |
| topic | Passion fruit left ventricular hypertrophy dyslipidemia oxidative stress |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100321&lng=en&tlng=en |
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