CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS
Abstract. We have observed eighty-nine patients with chronic recurrent infections of upper respiratory tract. Multiple immune parameters were evaluated during remissions of the disease. Increase in relative and absolute CD3+CD4+CD25+, CD3+HLA-DR+, CD3+CD16/CD56+ counts of blood lymphocytes, as well...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/377 |
| _version_ | 1797198100833501184 |
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| author | I. A. Novikova T. S. Petrenko |
| author_facet | I. A. Novikova T. S. Petrenko |
| author_sort | I. A. Novikova |
| collection | DOAJ |
| description | Abstract. We have observed eighty-nine patients with chronic recurrent infections of upper respiratory tract. Multiple immune parameters were evaluated during remissions of the disease. Increase in relative and absolute CD3+CD4+CD25+, CD3+HLA-DR+, CD3+CD16/CD56+ counts of blood lymphocytes, as well as higher concentrations of circulating immune complexes (CIC), along with decreased serum IgM and IgG levels were observed among the patients, as compared with appropriate parameters of control group. However, the major lymphocyte subsets did not differ between patients and controls. Hence, a content of CD3+CD16/CD56+ lymphocytes proved to be the most informative immunological parameter in the patients, since their levels directly correlate with duration of the disease and exacerbation rates. Meanwhile, CD3+СD16/СD56+cell counts show a negative correlation with the total numbers of B-lymphocytes and IgM concentrations in peripheral blood. |
| first_indexed | 2024-03-08T05:50:49Z |
| format | Article |
| id | doaj.art-8af4ef35534d40ee91787c062ffd555f |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:54:30Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-8af4ef35534d40ee91787c062ffd555f2024-04-22T13:07:36ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01144-542342810.15789/1563-0625-2012-4-5-423-428374CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONSI. A. Novikova0T. S. Petrenko1Гомельский государственный медицинский университет, г. ГомельГомельский государственный медицинский университет, г. ГомельAbstract. We have observed eighty-nine patients with chronic recurrent infections of upper respiratory tract. Multiple immune parameters were evaluated during remissions of the disease. Increase in relative and absolute CD3+CD4+CD25+, CD3+HLA-DR+, CD3+CD16/CD56+ counts of blood lymphocytes, as well as higher concentrations of circulating immune complexes (CIC), along with decreased serum IgM and IgG levels were observed among the patients, as compared with appropriate parameters of control group. However, the major lymphocyte subsets did not differ between patients and controls. Hence, a content of CD3+CD16/CD56+ lymphocytes proved to be the most informative immunological parameter in the patients, since their levels directly correlate with duration of the disease and exacerbation rates. Meanwhile, CD3+СD16/СD56+cell counts show a negative correlation with the total numbers of B-lymphocytes and IgM concentrations in peripheral blood.https://www.mimmun.ru/mimmun/article/view/377immune profilingrecurrent upper respiratory tract infection |
| spellingShingle | I. A. Novikova T. S. Petrenko CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS Медицинская иммунология immune profiling recurrent upper respiratory tract infection |
| title | CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS |
| title_full | CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS |
| title_fullStr | CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS |
| title_full_unstemmed | CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS |
| title_short | CLINICAL VALUE OF IMMUNE PROFILING IN PATIENTS WITH RECURRENT UPPER RESPIRATORY TRACT INFECTIONS |
| title_sort | clinical value of immune profiling in patients with recurrent upper respiratory tract infections |
| topic | immune profiling recurrent upper respiratory tract infection |
| url | https://www.mimmun.ru/mimmun/article/view/377 |
| work_keys_str_mv | AT ianovikova clinicalvalueofimmuneprofilinginpatientswithrecurrentupperrespiratorytractinfections AT tspetrenko clinicalvalueofimmuneprofilinginpatientswithrecurrentupperrespiratorytractinfections |