The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment
Head and neck squamous cell carcinomas (HNSCCs) refers to a group of highly malignant and pathogenically complex tumors. Traditional treatment methods include surgery, radiotherapy, and chemotherapy. However, with advancements in genetics, molecular medicine, and nanotherapy, more effective and safe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1189323/full |
| _version_ | 1797821435704508416 |
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| author | Ye Zhang Pengbo Dong Lu Yang |
| author_facet | Ye Zhang Pengbo Dong Lu Yang |
| author_sort | Ye Zhang |
| collection | DOAJ |
| description | Head and neck squamous cell carcinomas (HNSCCs) refers to a group of highly malignant and pathogenically complex tumors. Traditional treatment methods include surgery, radiotherapy, and chemotherapy. However, with advancements in genetics, molecular medicine, and nanotherapy, more effective and safer treatments have been developed. Nanotherapy, in particular, has the potential to be an alternative therapeutic option for HNSCC patients, given its advantageous targeting capabilities, low toxicity and modifiability. Recent research has highlighted the important role of the tumor microenvironment (TME) in the development of HNSCC. The TME is composed of various cellular components, such as fibroblasts, vascular endothelial cells, and immune cells, as well as non-cellular agents such as cytokines, chemokines, growth factors, extracellular matrix (ECM), and extracellular vesicles (EVs). These components greatly influence the prognosis and therapeutic efficacy of HNSCC, making the TME a potential target for treatment using nanotherapy. By regulating angiogenesis, immune response, tumor metastasis and other factors, nanotherapy can potentially alleviate HNSCC symptoms. This review aims to summarize and discuss the application of nanotherapy that targets HNSCC’s TME. We highlight the therapeutic value of nanotherapy for HNSCC patients. |
| first_indexed | 2024-03-13T09:52:40Z |
| format | Article |
| id | doaj.art-8af56146cac04fd7adb1db322ff8b0d4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T09:52:40Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8af56146cac04fd7adb1db322ff8b0d42023-05-24T05:59:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11893231189323The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironmentYe Zhang0Pengbo Dong1Lu Yang2Department of Radiation Oncology, Cancer Hospital of Dalian University of Technology/Liaoning Cancer Hospital and Institute, Shenyang, ChinaSchool of Energy and Power Engineering, Dalian University of Technology, Dalian, ChinaDepartment of Internal Medicine, Cancer Hospital of Dalian University of Technology/Liaoning Cancer Hospital and Institute, Shenyang, ChinaHead and neck squamous cell carcinomas (HNSCCs) refers to a group of highly malignant and pathogenically complex tumors. Traditional treatment methods include surgery, radiotherapy, and chemotherapy. However, with advancements in genetics, molecular medicine, and nanotherapy, more effective and safer treatments have been developed. Nanotherapy, in particular, has the potential to be an alternative therapeutic option for HNSCC patients, given its advantageous targeting capabilities, low toxicity and modifiability. Recent research has highlighted the important role of the tumor microenvironment (TME) in the development of HNSCC. The TME is composed of various cellular components, such as fibroblasts, vascular endothelial cells, and immune cells, as well as non-cellular agents such as cytokines, chemokines, growth factors, extracellular matrix (ECM), and extracellular vesicles (EVs). These components greatly influence the prognosis and therapeutic efficacy of HNSCC, making the TME a potential target for treatment using nanotherapy. By regulating angiogenesis, immune response, tumor metastasis and other factors, nanotherapy can potentially alleviate HNSCC symptoms. This review aims to summarize and discuss the application of nanotherapy that targets HNSCC’s TME. We highlight the therapeutic value of nanotherapy for HNSCC patients.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1189323/fullnanotherapyimmune microenvironmenthead and neck squamous cell carcinomatumor microenvironmentimmune response |
| spellingShingle | Ye Zhang Pengbo Dong Lu Yang The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment Frontiers in Immunology nanotherapy immune microenvironment head and neck squamous cell carcinoma tumor microenvironment immune response |
| title | The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment |
| title_full | The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment |
| title_fullStr | The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment |
| title_full_unstemmed | The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment |
| title_short | The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment |
| title_sort | role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment |
| topic | nanotherapy immune microenvironment head and neck squamous cell carcinoma tumor microenvironment immune response |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1189323/full |
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