Induction of CYP3A activity by dexamethasone may not be strong, even at high doses: insights from a case of tacrolimus co-administration

Induction of CYP3A activity by dexamethasone may not be strong, even at high doses: insights from a case of tacrolimus co-administration

Abstract Background Dexamethasone (DEX) induces CYP3A activity in a concentration-dependent manner. However, no study has examined changes in the blood concentration of CYP3A substrate drugs when DEX is administered at high doses. Herein, we present a case in which tacrolimus (TAC), a typical CYP3A...

Full description

Bibliographic Details
Main Authors: Yoshiyuki Ohno, Toyohito Oriyama, Akira Honda, Mineo Kurokawa, Tappei Takada
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Dexamethasone
CYP3A activity induction
Tacrolimus
Online Access:https://doi.org/10.1186/s40780-023-00310-0

Similar Items

Similar Items