Insulin Resistance and Type 2 Diabetes in Asymptomatic Obstructive Sleep Apnea: Results of the PROOF Cohort Study After 7 Years of Follow-Up
The aim of the study was to assess potential associations between obstructive sleep apnea (OSA) and the occurrence of diabetes mellitus and insulin resistance in the elderly. Nondiabetic volunteers (n = 549) with undiagnosed or untreated asymptomatic OSA (66.2+/−1 years at the inclusion) were evalua...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-07-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.650758/full |
| _version_ | 1819085296028876800 |
|---|---|
| author | Laurine Vacelet Laurine Vacelet David Hupin David Hupin Vincent Pichot Vincent Pichot Sébastien Celle Sébastien Celle Isabelle Court-Fortune Thierry Thomas Thierry Thomas Arnauld Garcin Arnauld Garcin Jean-Claude Barthélémy Jean-Claude Barthélémy David Gozal Frédéric Roche Frédéric Roche |
| author_facet | Laurine Vacelet Laurine Vacelet David Hupin David Hupin Vincent Pichot Vincent Pichot Sébastien Celle Sébastien Celle Isabelle Court-Fortune Thierry Thomas Thierry Thomas Arnauld Garcin Arnauld Garcin Jean-Claude Barthélémy Jean-Claude Barthélémy David Gozal Frédéric Roche Frédéric Roche |
| author_sort | Laurine Vacelet |
| collection | DOAJ |
| description | The aim of the study was to assess potential associations between obstructive sleep apnea (OSA) and the occurrence of diabetes mellitus and insulin resistance in the elderly. Nondiabetic volunteers (n = 549) with undiagnosed or untreated asymptomatic OSA (66.2+/−1 years at the inclusion) were evaluated as an ancillary study of the PROOF cohort study (n = 1,011). After 7 years follow-up, 494 subjects underwent assessment of fasting insulin and glucose levels. OSA was defined by an apnea-hypopnea index (AHI) of ≥15/h using polygraphy. Diabetes mellitus was defined by a fasting glucose ≥ 1.26 g/L and/or when requiring pharmacological treatment, while insulin resistance corresponded to HOMA-IR ≥ 2. Asymptomatic OSA subjects (men or women) did not display increased risk of incident diabetes (2.8 vs. 3.9%, p = 0.51). However, there was a greater frequency of insulin resistance in subjects with severe OSA (AHI > 30) [OR 2.21; 95% CI (1.22–4.02); p = 0.009]. Furthermore, multiple logistic regression showed that triglycerides levels [OR 1.61; 95% CI (1.10–2.36); p = 0.01] and fasting glycaemia [OR 4.69; 95% CI (1.12–192.78); p = 0.04], but not AHI or oxyhemoglobin desaturation index were independently associated with higher rate of insulin resistance. The deleterious metabolic effect of asymptomatic OSA in the population may be indirectly mediated via perturbations in lipids, and is particularly likely to become manifest in severe apneic subjects with higher glycemic levels. |
| first_indexed | 2024-12-21T21:02:06Z |
| format | Article |
| id | doaj.art-8af7572622a7488fa29cfeb07a2430d5 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T21:02:06Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8af7572622a7488fa29cfeb07a2430d52022-12-21T18:50:26ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-07-011210.3389/fphys.2021.650758650758Insulin Resistance and Type 2 Diabetes in Asymptomatic Obstructive Sleep Apnea: Results of the PROOF Cohort Study After 7 Years of Follow-UpLaurine Vacelet0Laurine Vacelet1David Hupin2David Hupin3Vincent Pichot4Vincent Pichot5Sébastien Celle6Sébastien Celle7Isabelle Court-Fortune8Thierry Thomas9Thierry Thomas10Arnauld Garcin11Arnauld Garcin12Jean-Claude Barthélémy13Jean-Claude Barthélémy14David Gozal15Frédéric Roche16Frédéric Roche17Service de Physiologie Clinique et de l’Exercice, CHU Saint Etienne, Saint Etienne Cedex, FranceSainbiose DVH U1059 Inserm, Faculté de Médecine J Lisfranc, Université Jean Monnet, Saint Etienne Cedex, FranceService de Physiologie Clinique et de l’Exercice, CHU Saint Etienne, Saint Etienne Cedex, FranceService de Pneumologie, CHU Saint Etienne, Saint Etienne Cedex, FranceService de Physiologie Clinique et de l’Exercice, CHU Saint Etienne, Saint Etienne Cedex, FranceService de Pneumologie, CHU Saint Etienne, Saint Etienne Cedex, FranceService de Physiologie Clinique et de l’Exercice, CHU Saint Etienne, Saint Etienne Cedex, FranceService de Pneumologie, CHU Saint Etienne, Saint Etienne Cedex, FranceSainbiose DVH U1059 Inserm, Faculté de Médecine J Lisfranc, Université Jean Monnet, Saint Etienne Cedex, FranceService de Pneumologie, CHU Saint Etienne, Saint Etienne Cedex, FranceService de Rhumatologie, CHU Saint Etienne, Saint Etienne Cedex, FranceService de Pneumologie, CHU Saint Etienne, Saint Etienne Cedex, FranceURCIP, CHU Saint Etienne, Saint Etienne Cedex, FranceService de Physiologie Clinique et de l’Exercice, CHU Saint Etienne, Saint Etienne Cedex, FranceService de Pneumologie, CHU Saint Etienne, Saint Etienne Cedex, FranceDepartment of Child Health, MU Women’s and Children’s Hospital, Columbia, MO, United StatesService de Physiologie Clinique et de l’Exercice, CHU Saint Etienne, Saint Etienne Cedex, FranceService de Pneumologie, CHU Saint Etienne, Saint Etienne Cedex, FranceThe aim of the study was to assess potential associations between obstructive sleep apnea (OSA) and the occurrence of diabetes mellitus and insulin resistance in the elderly. Nondiabetic volunteers (n = 549) with undiagnosed or untreated asymptomatic OSA (66.2+/−1 years at the inclusion) were evaluated as an ancillary study of the PROOF cohort study (n = 1,011). After 7 years follow-up, 494 subjects underwent assessment of fasting insulin and glucose levels. OSA was defined by an apnea-hypopnea index (AHI) of ≥15/h using polygraphy. Diabetes mellitus was defined by a fasting glucose ≥ 1.26 g/L and/or when requiring pharmacological treatment, while insulin resistance corresponded to HOMA-IR ≥ 2. Asymptomatic OSA subjects (men or women) did not display increased risk of incident diabetes (2.8 vs. 3.9%, p = 0.51). However, there was a greater frequency of insulin resistance in subjects with severe OSA (AHI > 30) [OR 2.21; 95% CI (1.22–4.02); p = 0.009]. Furthermore, multiple logistic regression showed that triglycerides levels [OR 1.61; 95% CI (1.10–2.36); p = 0.01] and fasting glycaemia [OR 4.69; 95% CI (1.12–192.78); p = 0.04], but not AHI or oxyhemoglobin desaturation index were independently associated with higher rate of insulin resistance. The deleterious metabolic effect of asymptomatic OSA in the population may be indirectly mediated via perturbations in lipids, and is particularly likely to become manifest in severe apneic subjects with higher glycemic levels.https://www.frontiersin.org/articles/10.3389/fphys.2021.650758/fullobstructive sleep apneaelderlyT2DMHOMA–IRcohort studyaging |
| spellingShingle | Laurine Vacelet Laurine Vacelet David Hupin David Hupin Vincent Pichot Vincent Pichot Sébastien Celle Sébastien Celle Isabelle Court-Fortune Thierry Thomas Thierry Thomas Arnauld Garcin Arnauld Garcin Jean-Claude Barthélémy Jean-Claude Barthélémy David Gozal Frédéric Roche Frédéric Roche Insulin Resistance and Type 2 Diabetes in Asymptomatic Obstructive Sleep Apnea: Results of the PROOF Cohort Study After 7 Years of Follow-Up Frontiers in Physiology obstructive sleep apnea elderly T2DM HOMA–IR cohort study aging |
| title | Insulin Resistance and Type 2 Diabetes in Asymptomatic Obstructive Sleep Apnea: Results of the PROOF Cohort Study After 7 Years of Follow-Up |
| title_full | Insulin Resistance and Type 2 Diabetes in Asymptomatic Obstructive Sleep Apnea: Results of the PROOF Cohort Study After 7 Years of Follow-Up |
| title_fullStr | Insulin Resistance and Type 2 Diabetes in Asymptomatic Obstructive Sleep Apnea: Results of the PROOF Cohort Study After 7 Years of Follow-Up |
| title_full_unstemmed | Insulin Resistance and Type 2 Diabetes in Asymptomatic Obstructive Sleep Apnea: Results of the PROOF Cohort Study After 7 Years of Follow-Up |
| title_short | Insulin Resistance and Type 2 Diabetes in Asymptomatic Obstructive Sleep Apnea: Results of the PROOF Cohort Study After 7 Years of Follow-Up |
| title_sort | insulin resistance and type 2 diabetes in asymptomatic obstructive sleep apnea results of the proof cohort study after 7 years of follow up |
| topic | obstructive sleep apnea elderly T2DM HOMA–IR cohort study aging |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.650758/full |
| work_keys_str_mv | AT laurinevacelet insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT laurinevacelet insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT davidhupin insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT davidhupin insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT vincentpichot insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT vincentpichot insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT sebastiencelle insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT sebastiencelle insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT isabellecourtfortune insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT thierrythomas insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT thierrythomas insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT arnauldgarcin insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT arnauldgarcin insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT jeanclaudebarthelemy insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT jeanclaudebarthelemy insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT davidgozal insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT fredericroche insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup AT fredericroche insulinresistanceandtype2diabetesinasymptomaticobstructivesleepapnearesultsoftheproofcohortstudyafter7yearsoffollowup |