Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation
Purpose Diabetes mellitus (DM) increases the risk of morbidity and mortality after liver resection. Albuminuria is associated with a higher risk for all-cause and cardiovascular mortality. This study evaluated albuminuria as a predictor of the outcome of living donor liver transplantation (LDLT) in...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2022.2124446 |
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| author | Ahmed Abdallah Salman Mohamed Abdalla Salman Mostafa Said Hesham Elkassar Mohammad El Sherbiny Ahmed Youssef Mohammed Elbaz Ahmed M. Elmeligui Mohamed Badr Hassan Mahmoud Gouda Omar Hussien Samir Mohamed Abdelkader Morad Hossam El-Din Shaaban Mohamed Youssef Ahmed Moustafa Mohamed Sabry Tourky Ahmed Elewa Sadaf Khalid Khaled Monazea Mohamed Shawkat |
| author_facet | Ahmed Abdallah Salman Mohamed Abdalla Salman Mostafa Said Hesham Elkassar Mohammad El Sherbiny Ahmed Youssef Mohammed Elbaz Ahmed M. Elmeligui Mohamed Badr Hassan Mahmoud Gouda Omar Hussien Samir Mohamed Abdelkader Morad Hossam El-Din Shaaban Mohamed Youssef Ahmed Moustafa Mohamed Sabry Tourky Ahmed Elewa Sadaf Khalid Khaled Monazea Mohamed Shawkat |
| author_sort | Ahmed Abdallah Salman |
| collection | DOAJ |
| description | Purpose Diabetes mellitus (DM) increases the risk of morbidity and mortality after liver resection. Albuminuria is associated with a higher risk for all-cause and cardiovascular mortality. This study evaluated albuminuria as a predictor of the outcome of living donor liver transplantation (LDLT) in patients with pre-existing DM.Methods This retrospective study involved 103 type II diabetic patients with end-stage liver disease who received LDLT. Preoperative spot urine albumin: creatinine ratio was used to determine the degree of albuminuria. The primary outcome measure was the impact of urinary albumin excretion on the 3-year mortality rate after LDLT in this diabetic cohort.Results Hepatitis C virus infection was the main cause of cirrhosis. Albuminuria was detected in 41 patients (39.8%); 15 had macroalbuminuria, while 26 had microalbuminuria. Patients with microalbuminuria were significantly older than those with macroalbuminuria and normal albumin in urine. After 3 years, twenty-four patients (23.3%) died within 3 years after LT. Myocardial infarction was the leading cause of death (25%). Albuminuria was an independent factor affecting 3-year mortality with an odds ratio of 5.17 (95% CI: 1.86–14.35).Conclusion Preoperative albuminuria is an independent factor affecting mortality within 3 years after LDLT in type II diabetic patients. Myocardial infarction was the leading cause of death in 25% of cases, followed by hepatocellular carcinoma recurrence, sepsis, and graft failure.KEY MESSAGESDiabetes mellitus (DM) increases the risk of morbidity and mortality after liver resection.Albuminuria is associated with a higher risk for all-cause and cardiovascular mortality.Preoperative albuminuria is a significant predictor of mortality within 3 years after LDLT in diabetic patients. |
| first_indexed | 2024-04-12T03:01:56Z |
| format | Article |
| id | doaj.art-8af89492c2674d7f90a3616b369d52f9 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-04-12T03:01:56Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-8af89492c2674d7f90a3616b369d52f92022-12-22T03:50:37ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602022-12-015412598260510.1080/07853890.2022.2124446Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantationAhmed Abdallah Salman0Mohamed Abdalla Salman1Mostafa Said2Hesham Elkassar3Mohammad El Sherbiny4Ahmed Youssef5Mohammed Elbaz6Ahmed M. Elmeligui7Mohamed Badr Hassan8Mahmoud Gouda Omar9Hussien Samir10Mohamed Abdelkader Morad11Hossam El-Din Shaaban12Mohamed Youssef13Ahmed Moustafa14Mohamed Sabry Tourky15Ahmed Elewa16Sadaf Khalid17Khaled Monazea18Mohamed Shawkat19Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptGeneral Surgery Department, Faculty of Medicine, Cairo University, Cairo, EgyptInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptGastroenterology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, EgyptDepartment of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, EgyptDepartment of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, EgyptDepartment of Surgery, Great Western Hospitals NHS Foundation Trust, Swindon, UKGeneral Surgery Department, National Hepatology and Tropical Medicine Research Institute, Cairo, EgyptGeneral Surgery Department, Royal Free Hospital, London, UKGeneral Surgery Department, Assiut Faculty of Medicine for Boys, Al-Azhar University, Cairo, EgyptInternal Medicine Department, Faculty of Medicine, Minia University, Minia, EgyptPurpose Diabetes mellitus (DM) increases the risk of morbidity and mortality after liver resection. Albuminuria is associated with a higher risk for all-cause and cardiovascular mortality. This study evaluated albuminuria as a predictor of the outcome of living donor liver transplantation (LDLT) in patients with pre-existing DM.Methods This retrospective study involved 103 type II diabetic patients with end-stage liver disease who received LDLT. Preoperative spot urine albumin: creatinine ratio was used to determine the degree of albuminuria. The primary outcome measure was the impact of urinary albumin excretion on the 3-year mortality rate after LDLT in this diabetic cohort.Results Hepatitis C virus infection was the main cause of cirrhosis. Albuminuria was detected in 41 patients (39.8%); 15 had macroalbuminuria, while 26 had microalbuminuria. Patients with microalbuminuria were significantly older than those with macroalbuminuria and normal albumin in urine. After 3 years, twenty-four patients (23.3%) died within 3 years after LT. Myocardial infarction was the leading cause of death (25%). Albuminuria was an independent factor affecting 3-year mortality with an odds ratio of 5.17 (95% CI: 1.86–14.35).Conclusion Preoperative albuminuria is an independent factor affecting mortality within 3 years after LDLT in type II diabetic patients. Myocardial infarction was the leading cause of death in 25% of cases, followed by hepatocellular carcinoma recurrence, sepsis, and graft failure.KEY MESSAGESDiabetes mellitus (DM) increases the risk of morbidity and mortality after liver resection.Albuminuria is associated with a higher risk for all-cause and cardiovascular mortality.Preoperative albuminuria is a significant predictor of mortality within 3 years after LDLT in diabetic patients.https://www.tandfonline.com/doi/10.1080/07853890.2022.2124446Liver transplantalbuminuriadiabetes |
| spellingShingle | Ahmed Abdallah Salman Mohamed Abdalla Salman Mostafa Said Hesham Elkassar Mohammad El Sherbiny Ahmed Youssef Mohammed Elbaz Ahmed M. Elmeligui Mohamed Badr Hassan Mahmoud Gouda Omar Hussien Samir Mohamed Abdelkader Morad Hossam El-Din Shaaban Mohamed Youssef Ahmed Moustafa Mohamed Sabry Tourky Ahmed Elewa Sadaf Khalid Khaled Monazea Mohamed Shawkat Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation Annals of Medicine Liver transplant albuminuria diabetes |
| title | Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation |
| title_full | Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation |
| title_fullStr | Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation |
| title_full_unstemmed | Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation |
| title_short | Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation |
| title_sort | albuminuria as a predictor of mortality in type ii diabetic patients after living donor liver transplantation |
| topic | Liver transplant albuminuria diabetes |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2022.2124446 |
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