Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges
In recent years, aquaporin biomimetic membranes (ABMs) for water separation have gained considerable interest. Although the first ABMs are commercially available, there are still many challenges associated with further ABM development. Here, we discuss the interplay of the main components of ABMs: a...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-07-01
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| Series: | Membranes |
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| Online Access: | http://www.mdpi.com/2077-0375/5/3/307 |
| _version_ | 1797762466075115520 |
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| author | Joachim Habel Michael Hansen Søren Kynde Nanna Larsen Søren Roi Midtgaard Grethe Vestergaard Jensen Julie Bomholt Anayo Ogbonna Kristoffer Almdal Alexander Schulz Claus Hélix-Nielsen |
| author_facet | Joachim Habel Michael Hansen Søren Kynde Nanna Larsen Søren Roi Midtgaard Grethe Vestergaard Jensen Julie Bomholt Anayo Ogbonna Kristoffer Almdal Alexander Schulz Claus Hélix-Nielsen |
| author_sort | Joachim Habel |
| collection | DOAJ |
| description | In recent years, aquaporin biomimetic membranes (ABMs) for water separation have gained considerable interest. Although the first ABMs are commercially available, there are still many challenges associated with further ABM development. Here, we discuss the interplay of the main components of ABMs: aquaporin proteins (AQPs), block copolymers for AQP reconstitution, and polymer-based supporting structures. First, we briefly cover challenges and review recent developments in understanding the interplay between AQP and block copolymers. Second, we review some experimental characterization methods for investigating AQP incorporation including freeze-fracture transmission electron microscopy, fluorescence correlation spectroscopy, stopped-flow light scattering, and small-angle X-ray scattering. Third, we focus on recent efforts in embedding reconstituted AQPs in membrane designs that are based on conventional thin film interfacial polymerization techniques. Finally, we describe some new developments in interfacial polymerization using polyhedral oligomeric silsesquioxane cages for increasing the physical and chemical durability of thin film composite membranes. |
| first_indexed | 2024-03-12T19:28:45Z |
| format | Article |
| id | doaj.art-8afb345ba5f943e4aac4212ad6569c40 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-12T19:28:45Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-8afb345ba5f943e4aac4212ad6569c402023-08-02T04:45:08ZengMDPI AGMembranes2077-03752015-07-015330735110.3390/membranes5030307membranes5030307Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and ChallengesJoachim Habel0Michael Hansen1Søren Kynde2Nanna Larsen3Søren Roi Midtgaard4Grethe Vestergaard Jensen5Julie Bomholt6Anayo Ogbonna7Kristoffer Almdal8Alexander Schulz9Claus Hélix-Nielsen10Technical University of Denmark, Department of Environmental Engineering, Miljøvej, Building 113, 2800 Kgs. Lyngby, DenmarkUniversity of Copenhagen, Department of Plant and Environmental Sciences, Thorvaldsensvej 40, 1871 Frederiksberg, DenmarkUniversity of Copenhagen, Copenhagen Biocenter, Ole Maaløes Vej 5, 2200 Copenhagen, DenmarkUniversity of Copenhagen, Niels Bohr Institute, Hans Christian Ørsted building D, Universitetsparken, 5, 2100 Copenhagen, DenmarkUniversity of Copenhagen, Copenhagen Biocenter, Ole Maaløes Vej 5, 2200 Copenhagen, DenmarkUniversity of Copenhagen, Copenhagen Biocenter, Ole Maaløes Vej 5, 2200 Copenhagen, DenmarkAquaporin A/S, Ole Maaløes Vej 3, 2200 Copenhagen, DenmarkAquaporin A/S, Ole Maaløes Vej 3, 2200 Copenhagen, DenmarkTechnical University of Denmark, Department of Micro- and Nanotechnology, Produktionstorvet, Building 423, 2800 Kgs. LyngbyUniversity of Copenhagen, Department of Plant and Environmental Sciences, Thorvaldsensvej 40, 1871 Frederiksberg, DenmarkTechnical University of Denmark, Department of Environmental Engineering, Miljøvej, Building 113, 2800 Kgs. Lyngby, DenmarkIn recent years, aquaporin biomimetic membranes (ABMs) for water separation have gained considerable interest. Although the first ABMs are commercially available, there are still many challenges associated with further ABM development. Here, we discuss the interplay of the main components of ABMs: aquaporin proteins (AQPs), block copolymers for AQP reconstitution, and polymer-based supporting structures. First, we briefly cover challenges and review recent developments in understanding the interplay between AQP and block copolymers. Second, we review some experimental characterization methods for investigating AQP incorporation including freeze-fracture transmission electron microscopy, fluorescence correlation spectroscopy, stopped-flow light scattering, and small-angle X-ray scattering. Third, we focus on recent efforts in embedding reconstituted AQPs in membrane designs that are based on conventional thin film interfacial polymerization techniques. Finally, we describe some new developments in interfacial polymerization using polyhedral oligomeric silsesquioxane cages for increasing the physical and chemical durability of thin film composite membranes.http://www.mdpi.com/2077-0375/5/3/307biomimetic membranesaquaporinsblock copolymersproteopolymersomespolyhedral oligomeric silsesquioxanespolyamide layermicrofluidicsmembrane proteinsprotein-polymer-interactions |
| spellingShingle | Joachim Habel Michael Hansen Søren Kynde Nanna Larsen Søren Roi Midtgaard Grethe Vestergaard Jensen Julie Bomholt Anayo Ogbonna Kristoffer Almdal Alexander Schulz Claus Hélix-Nielsen Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges Membranes biomimetic membranes aquaporins block copolymers proteopolymersomes polyhedral oligomeric silsesquioxanes polyamide layer microfluidics membrane proteins protein-polymer-interactions |
| title | Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges |
| title_full | Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges |
| title_fullStr | Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges |
| title_full_unstemmed | Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges |
| title_short | Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges |
| title_sort | aquaporin based biomimetic polymeric membranes approaches and challenges |
| topic | biomimetic membranes aquaporins block copolymers proteopolymersomes polyhedral oligomeric silsesquioxanes polyamide layer microfluidics membrane proteins protein-polymer-interactions |
| url | http://www.mdpi.com/2077-0375/5/3/307 |
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