High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis
Suppression of gene expression due to aberrant promoter methylation contributes to organ fibrosis. Here, the authors couple a deactivated Cas9 to the TET3 catalytic domain to induce expression of four antifibrotic genes, and show that lentiviral-mediated delivery is effective in reducing kidney fibr...
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Bibliographic Details
Main Authors: |
Xingbo Xu,
Xiaoying Tan,
Björn Tampe,
Tim Wilhelmi,
Melanie S. Hulshoff,
Shoji Saito,
Tobias Moser,
Raghu Kalluri,
Gerd Hasenfuss,
Elisabeth M. Zeisberg,
Michael Zeisberg |
Format: | Article
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Language: | English |
Published: |
Nature Portfolio
2018-08-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-018-05766-5
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