Comparisons of Viral Etiology and Outcomes of Hepatocellular Carcinoma Undergoing Liver Resection between Taiwan and Vietnam
Epidemiologic data have suggested that etiologic variations of hepatocellular carcinoma (HCC) exist in different geographic areas, and might be associated with different outcomes. We compared the viral etiology, clinicopathological characteristics and surgical outcomes between 706 Taiwanese and 1704...
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MDPI AG
2022-11-01
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| Online Access: | https://www.mdpi.com/1999-4915/14/11/2571 |
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| author | Song-Huy Nguyen-Dinh Wei-Feng Li Yueh-Wei Liu Chih-Chi Wang Yen-Hao Chen Jing-Houng Wang Chao-Hung Hung |
| author_facet | Song-Huy Nguyen-Dinh Wei-Feng Li Yueh-Wei Liu Chih-Chi Wang Yen-Hao Chen Jing-Houng Wang Chao-Hung Hung |
| author_sort | Song-Huy Nguyen-Dinh |
| collection | DOAJ |
| description | Epidemiologic data have suggested that etiologic variations of hepatocellular carcinoma (HCC) exist in different geographic areas, and might be associated with different outcomes. We compared the viral etiology, clinicopathological characteristics and surgical outcomes between 706 Taiwanese and 1704 Vietnamese patients with HCC undergoing liver resection. Vietnamese patients had a significantly higher ratio of hepatitis B virus (HBV) (<i>p</i> < 0.001) and a lower ratio of hepatitis C virus (HCV) (<i>p</i> < 0.001) and non-B non-C than Taiwanese patients. Among patients with HBV or non-B non-C, the mean age was younger in Vietnam than in Taiwan (<i>p</i> < 0.001, <i>p</i> = 0.001, respectively). The HCC patients in Vietnam had significantly higher serum alpha-fetoprotein (AFP) levels (<i>p</i> < 0.001), larger tumors (<i>p</i> < 0.001), and a higher ratio of macrovascular invasion (<i>p</i> < 0.001) and extrahepatic metastasis (<i>p</i> < 0.001), compared to those in Taiwan. Patients treated in Vietnam had a higher tumor recurrent rate (<i>p</i> < 0.001), but no difference in overall survival was found between both groups. In subgroup analysis, the recurrent rate of HCC was the highest in patients with dual HBV/HCV, followed by HCV or HBV, and non-B non-C (<i>p</i> < 0.001). In conclusion, although the viral etiology and clinicopathological characteristics of HCC differed, postoperative overall survival was comparable between patients in Taiwan and Vietnam. |
| first_indexed | 2024-03-09T17:56:18Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T17:56:18Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-8afd0ae662f64fc6b49e50ef2a201a0c2023-11-24T10:19:23ZengMDPI AGViruses1999-49152022-11-011411257110.3390/v14112571Comparisons of Viral Etiology and Outcomes of Hepatocellular Carcinoma Undergoing Liver Resection between Taiwan and VietnamSong-Huy Nguyen-Dinh0Wei-Feng Li1Yueh-Wei Liu2Chih-Chi Wang3Yen-Hao Chen4Jing-Houng Wang5Chao-Hung Hung6Liver Tumor Department, Cho Ray Hospital, Ho Chi Minh City 70250, VietnamLiver Transplant Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83300, TaiwanLiver Transplant Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83300, TaiwanLiver Transplant Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83300, TaiwanDivision of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83300, TaiwanDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83300, TaiwanDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83300, TaiwanEpidemiologic data have suggested that etiologic variations of hepatocellular carcinoma (HCC) exist in different geographic areas, and might be associated with different outcomes. We compared the viral etiology, clinicopathological characteristics and surgical outcomes between 706 Taiwanese and 1704 Vietnamese patients with HCC undergoing liver resection. Vietnamese patients had a significantly higher ratio of hepatitis B virus (HBV) (<i>p</i> < 0.001) and a lower ratio of hepatitis C virus (HCV) (<i>p</i> < 0.001) and non-B non-C than Taiwanese patients. Among patients with HBV or non-B non-C, the mean age was younger in Vietnam than in Taiwan (<i>p</i> < 0.001, <i>p</i> = 0.001, respectively). The HCC patients in Vietnam had significantly higher serum alpha-fetoprotein (AFP) levels (<i>p</i> < 0.001), larger tumors (<i>p</i> < 0.001), and a higher ratio of macrovascular invasion (<i>p</i> < 0.001) and extrahepatic metastasis (<i>p</i> < 0.001), compared to those in Taiwan. Patients treated in Vietnam had a higher tumor recurrent rate (<i>p</i> < 0.001), but no difference in overall survival was found between both groups. In subgroup analysis, the recurrent rate of HCC was the highest in patients with dual HBV/HCV, followed by HCV or HBV, and non-B non-C (<i>p</i> < 0.001). In conclusion, although the viral etiology and clinicopathological characteristics of HCC differed, postoperative overall survival was comparable between patients in Taiwan and Vietnam.https://www.mdpi.com/1999-4915/14/11/2571hepatocellular carcinomahepatitis B virushepatitis C virusrecurrencesurvival |
| spellingShingle | Song-Huy Nguyen-Dinh Wei-Feng Li Yueh-Wei Liu Chih-Chi Wang Yen-Hao Chen Jing-Houng Wang Chao-Hung Hung Comparisons of Viral Etiology and Outcomes of Hepatocellular Carcinoma Undergoing Liver Resection between Taiwan and Vietnam Viruses hepatocellular carcinoma hepatitis B virus hepatitis C virus recurrence survival |
| title | Comparisons of Viral Etiology and Outcomes of Hepatocellular Carcinoma Undergoing Liver Resection between Taiwan and Vietnam |
| title_full | Comparisons of Viral Etiology and Outcomes of Hepatocellular Carcinoma Undergoing Liver Resection between Taiwan and Vietnam |
| title_fullStr | Comparisons of Viral Etiology and Outcomes of Hepatocellular Carcinoma Undergoing Liver Resection between Taiwan and Vietnam |
| title_full_unstemmed | Comparisons of Viral Etiology and Outcomes of Hepatocellular Carcinoma Undergoing Liver Resection between Taiwan and Vietnam |
| title_short | Comparisons of Viral Etiology and Outcomes of Hepatocellular Carcinoma Undergoing Liver Resection between Taiwan and Vietnam |
| title_sort | comparisons of viral etiology and outcomes of hepatocellular carcinoma undergoing liver resection between taiwan and vietnam |
| topic | hepatocellular carcinoma hepatitis B virus hepatitis C virus recurrence survival |
| url | https://www.mdpi.com/1999-4915/14/11/2571 |
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