In vitro and in vivo activities of a novel β-lactamase inhibitor combination imipenem/XNW4107 against recent clinical Gram-negative bacilli from China

In vitro and in vivo activities of a novel β-lactamase inhibitor combination imipenem/XNW4107 against recent clinical Gram-negative bacilli from China

ABSTRACT: Objectives: XNW4107 is a novel β-lactamase inhibitor that possesses broad activity against serine-β-lactamases. XNW4107 in combination with imipenem exhibited potent in vitro activity against carbapenem-resistant bacteria and particularly against carbapenem-resistant Acinetobacter baumann...

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Bibliographic Details
Main Authors: Yun Li, Mengyao Yan, Feng Xue, Wei Zhong, Xiao Liu, Xi Chen, Yuchuan Wu, Jia Zhang, Qing Wang, Bo Zheng, Yuan Lv
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Imipenem/XNW4107
β-lactam combination agent
In vitro
In vivo
Antibacterial activity
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716522001722

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