A Systems Engineering Perspective on Homeostasis and Disease
Engineered systems are coupled networks of interacting sub-systems, whose dynamics are constrained to requirements of robustness and flexibility. They have evolved by design to optimize function in a changing environment and maintain responses within ranges. Analysis, synthesis, and design of comple...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fbioe.2013.00006/full |
| _version_ | 1828389592212963328 |
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| author | Yoram eVodovotz Gary eAn Ioannis P Androulakis |
| author_facet | Yoram eVodovotz Gary eAn Ioannis P Androulakis |
| author_sort | Yoram eVodovotz |
| collection | DOAJ |
| description | Engineered systems are coupled networks of interacting sub-systems, whose dynamics are constrained to requirements of robustness and flexibility. They have evolved by design to optimize function in a changing environment and maintain responses within ranges. Analysis, synthesis, and design of complex supply chains aim to identify and explore the laws governing optimally integrated systems. Optimality expresses balance between conflicting objectives while resiliency results from dynamic interactions among elements. Our increasing understanding of life’s multi-scale architecture suggests that living systems share similar characteristics with much to be learned about biological complexity from engineered systems. If health reflects a dynamically stable integration of molecules, cell, tissues and organs; disease indicates displacement compensated for and corrected by activation and combination of feedback mechanisms through interconnected networks. In this article, we draw analogies between concepts in systems engineering and conceptual models of health and disease; establish connections between these concepts and physiologic modeling; and describe how these mirror onto the physiological counterparts of engineered systems. |
| first_indexed | 2024-12-10T06:31:55Z |
| format | Article |
| id | doaj.art-8afdb3cf57e74321998cdc11dbcd16fb |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-10T06:31:55Z |
| publishDate | 2013-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-8afdb3cf57e74321998cdc11dbcd16fb2022-12-22T01:59:02ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852013-09-01110.3389/fbioe.2013.0000663323A Systems Engineering Perspective on Homeostasis and DiseaseYoram eVodovotz0Gary eAn1Ioannis P Androulakis2University of PittsburghUniversity of ChicagoRutgers, The State University of new JerseyEngineered systems are coupled networks of interacting sub-systems, whose dynamics are constrained to requirements of robustness and flexibility. They have evolved by design to optimize function in a changing environment and maintain responses within ranges. Analysis, synthesis, and design of complex supply chains aim to identify and explore the laws governing optimally integrated systems. Optimality expresses balance between conflicting objectives while resiliency results from dynamic interactions among elements. Our increasing understanding of life’s multi-scale architecture suggests that living systems share similar characteristics with much to be learned about biological complexity from engineered systems. If health reflects a dynamically stable integration of molecules, cell, tissues and organs; disease indicates displacement compensated for and corrected by activation and combination of feedback mechanisms through interconnected networks. In this article, we draw analogies between concepts in systems engineering and conceptual models of health and disease; establish connections between these concepts and physiologic modeling; and describe how these mirror onto the physiological counterparts of engineered systems.http://journal.frontiersin.org/Journal/10.3389/fbioe.2013.00006/fullHomeostasisHumansSystems BiologyTraumamultiscale modelingSystems Engineering |
| spellingShingle | Yoram eVodovotz Gary eAn Ioannis P Androulakis A Systems Engineering Perspective on Homeostasis and Disease Frontiers in Bioengineering and Biotechnology Homeostasis Humans Systems Biology Trauma multiscale modeling Systems Engineering |
| title | A Systems Engineering Perspective on Homeostasis and Disease |
| title_full | A Systems Engineering Perspective on Homeostasis and Disease |
| title_fullStr | A Systems Engineering Perspective on Homeostasis and Disease |
| title_full_unstemmed | A Systems Engineering Perspective on Homeostasis and Disease |
| title_short | A Systems Engineering Perspective on Homeostasis and Disease |
| title_sort | systems engineering perspective on homeostasis and disease |
| topic | Homeostasis Humans Systems Biology Trauma multiscale modeling Systems Engineering |
| url | http://journal.frontiersin.org/Journal/10.3389/fbioe.2013.00006/full |
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