Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report
Background: Synchronous bilateral breast cancer (SBBC) provides a special condition where two independent breast tumors are exposed to cancer pharmacotherapy within a uniform pharmacokinetic milieu. Both senescence and apoptosis are established responses to therapy; however, they have potentially va...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/28/5/327 |
| _version_ | 1797514869986033664 |
|---|---|
| author | Tareq Saleh Mohammed El-Sadoni Ahmad Alhesa Heyam Awad Mahmoud Jaradat Mohammad Al-Hazaimeh Rand Dawoud Amel Mryyian Bilal Azab |
| author_facet | Tareq Saleh Mohammed El-Sadoni Ahmad Alhesa Heyam Awad Mahmoud Jaradat Mohammad Al-Hazaimeh Rand Dawoud Amel Mryyian Bilal Azab |
| author_sort | Tareq Saleh |
| collection | DOAJ |
| description | Background: Synchronous bilateral breast cancer (SBBC) provides a special condition where two independent breast tumors are exposed to cancer pharmacotherapy within a uniform pharmacokinetic milieu. Both senescence and apoptosis are established responses to therapy; however, they have potentially variable contributions to the overall outcome of treatment, which are yet to be determined. Methods: In this report, we describe the clinicopathological picture of two SBBC cases that received standard anticancer treatment and assess their expression profile of several molecular hallmarks of senescence and apoptosis. Results: Our analysis identified that synchronous tumors have variable expression profiles of both senescence- and apoptosis-associated biomarkers, despite comparable pathological responses to neoadjuvant chemotherapy and current survival rates. Conclusions: Our results highlight the variable expression of senescence- and apoptosis-associated markers in breast tumors (despite the shared somatic genetic background) and invites a large-scale assessment of both senescence and apoptosis in breast cancer tissue in vivo and their contribution to the pathological response and overall survival. |
| first_indexed | 2024-03-10T06:37:40Z |
| format | Article |
| id | doaj.art-8afdc04f2afd4564aa1275b8458913d2 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T06:37:40Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-8afdc04f2afd4564aa1275b8458913d22023-11-22T17:55:02ZengMDPI AGCurrent Oncology1198-00521718-77292021-09-012853836384510.3390/curroncol28050327Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case ReportTareq Saleh0Mohammed El-Sadoni1Ahmad Alhesa2Heyam Awad3Mahmoud Jaradat4Mohammad Al-Hazaimeh5Rand Dawoud6Amel Mryyian7Bilal Azab8Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa 13133, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, JordanDepartment of General Surgery, Jordanian Royal Medical Services, Amman 11942, JordanDepartment of General Surgery, Jordanian Royal Medical Services, Amman 11942, JordanDepartment of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa 13133, JordanDepartment of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa 13133, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, JordanBackground: Synchronous bilateral breast cancer (SBBC) provides a special condition where two independent breast tumors are exposed to cancer pharmacotherapy within a uniform pharmacokinetic milieu. Both senescence and apoptosis are established responses to therapy; however, they have potentially variable contributions to the overall outcome of treatment, which are yet to be determined. Methods: In this report, we describe the clinicopathological picture of two SBBC cases that received standard anticancer treatment and assess their expression profile of several molecular hallmarks of senescence and apoptosis. Results: Our analysis identified that synchronous tumors have variable expression profiles of both senescence- and apoptosis-associated biomarkers, despite comparable pathological responses to neoadjuvant chemotherapy and current survival rates. Conclusions: Our results highlight the variable expression of senescence- and apoptosis-associated markers in breast tumors (despite the shared somatic genetic background) and invites a large-scale assessment of both senescence and apoptosis in breast cancer tissue in vivo and their contribution to the pathological response and overall survival.https://www.mdpi.com/1718-7729/28/5/327senescenceapoptosisBCL-2p16<sup>INK4a</sup>chemotherapysynchronous |
| spellingShingle | Tareq Saleh Mohammed El-Sadoni Ahmad Alhesa Heyam Awad Mahmoud Jaradat Mohammad Al-Hazaimeh Rand Dawoud Amel Mryyian Bilal Azab Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report Current Oncology senescence apoptosis BCL-2 p16<sup>INK4a</sup> chemotherapy synchronous |
| title | Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report |
| title_full | Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report |
| title_fullStr | Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report |
| title_full_unstemmed | Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report |
| title_short | Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report |
| title_sort | expression of senescence and apoptosis biomarkers in synchronous bilateral breast cancer a case report |
| topic | senescence apoptosis BCL-2 p16<sup>INK4a</sup> chemotherapy synchronous |
| url | https://www.mdpi.com/1718-7729/28/5/327 |
| work_keys_str_mv | AT tareqsaleh expressionofsenescenceandapoptosisbiomarkersinsynchronousbilateralbreastcanceracasereport AT mohammedelsadoni expressionofsenescenceandapoptosisbiomarkersinsynchronousbilateralbreastcanceracasereport AT ahmadalhesa expressionofsenescenceandapoptosisbiomarkersinsynchronousbilateralbreastcanceracasereport AT heyamawad expressionofsenescenceandapoptosisbiomarkersinsynchronousbilateralbreastcanceracasereport AT mahmoudjaradat expressionofsenescenceandapoptosisbiomarkersinsynchronousbilateralbreastcanceracasereport AT mohammadalhazaimeh expressionofsenescenceandapoptosisbiomarkersinsynchronousbilateralbreastcanceracasereport AT randdawoud expressionofsenescenceandapoptosisbiomarkersinsynchronousbilateralbreastcanceracasereport AT amelmryyian expressionofsenescenceandapoptosisbiomarkersinsynchronousbilateralbreastcanceracasereport AT bilalazab expressionofsenescenceandapoptosisbiomarkersinsynchronousbilateralbreastcanceracasereport |