Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation
Cancer is still one of the main causes of morbidity and death rate around the world, although diagnostic and therapeutic technologies are used to advance human disease treatment. Currently, surgical resection of solid tumors is the most effective and a prior remedial measure to treat cancer. Althoug...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.768698/full |
| _version_ | 1819140480995164160 |
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| author | Songjiao Li Dan Cheng Dan Cheng Longwei He Lin Yuan |
| author_facet | Songjiao Li Dan Cheng Dan Cheng Longwei He Lin Yuan |
| author_sort | Songjiao Li |
| collection | DOAJ |
| description | Cancer is still one of the main causes of morbidity and death rate around the world, although diagnostic and therapeutic technologies are used to advance human disease treatment. Currently, surgical resection of solid tumors is the most effective and a prior remedial measure to treat cancer. Although medical treatment, technology, and science have advanced significantly, it is challenging to completely treat this lethal disease. Near-infrared (NIR) fluorescence, including the first near-infrared region (NIR-I, 650–900 nm) and the second near-infrared region (NIR-II, 1,000–1,700 nm), plays an important role in image-guided cancer surgeries due to its inherent advantages, such as great tissue penetration, minimal tissue absorption and emission light scattering, and low autofluorescence. By virtue of its high precision in identifying tumor tissue margins, there are growing number of NIR fluorescence-guided surgeries for various living animal models as well as patients in clinical therapy. Herein, this review introduces the basic construction and operation principles of fluorescence molecular imaging technology, and the representative application of NIR-I/II image-guided surgery in biomedical research studies are summarized. Ultimately, we discuss the present challenges and future perspectives in the field of fluorescence imaging for surgical navigation and also put forward our opinions on how to improve the efficiency of the surgical treatment. |
| first_indexed | 2024-12-22T11:39:14Z |
| format | Article |
| id | doaj.art-8afde9b83e464bf1b83c0d78bff9c6ef |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-22T11:39:14Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-8afde9b83e464bf1b83c0d78bff9c6ef2022-12-21T18:27:20ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-11-01910.3389/fbioe.2021.768698768698Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical NavigationSongjiao Li0Dan Cheng1Dan Cheng2Longwei He3Lin Yuan4Cancer Research Institute, Department of Pharmacy and Pharmacology, The First Affiliated Hospital, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, ChinaThe Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, ChinaCancer Research Institute, Department of Pharmacy and Pharmacology, The First Affiliated Hospital, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, ChinaState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, ChinaCancer is still one of the main causes of morbidity and death rate around the world, although diagnostic and therapeutic technologies are used to advance human disease treatment. Currently, surgical resection of solid tumors is the most effective and a prior remedial measure to treat cancer. Although medical treatment, technology, and science have advanced significantly, it is challenging to completely treat this lethal disease. Near-infrared (NIR) fluorescence, including the first near-infrared region (NIR-I, 650–900 nm) and the second near-infrared region (NIR-II, 1,000–1,700 nm), plays an important role in image-guided cancer surgeries due to its inherent advantages, such as great tissue penetration, minimal tissue absorption and emission light scattering, and low autofluorescence. By virtue of its high precision in identifying tumor tissue margins, there are growing number of NIR fluorescence-guided surgeries for various living animal models as well as patients in clinical therapy. Herein, this review introduces the basic construction and operation principles of fluorescence molecular imaging technology, and the representative application of NIR-I/II image-guided surgery in biomedical research studies are summarized. Ultimately, we discuss the present challenges and future perspectives in the field of fluorescence imaging for surgical navigation and also put forward our opinions on how to improve the efficiency of the surgical treatment.https://www.frontiersin.org/articles/10.3389/fbioe.2021.768698/fullsurgical navigationNIR-INIR-IItumorfluorescence imagingimage-guided cancer surgeries |
| spellingShingle | Songjiao Li Dan Cheng Dan Cheng Longwei He Lin Yuan Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation Frontiers in Bioengineering and Biotechnology surgical navigation NIR-I NIR-II tumor fluorescence imaging image-guided cancer surgeries |
| title | Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation |
| title_full | Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation |
| title_fullStr | Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation |
| title_full_unstemmed | Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation |
| title_short | Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation |
| title_sort | recent progresses in nir i ii fluorescence imaging for surgical navigation |
| topic | surgical navigation NIR-I NIR-II tumor fluorescence imaging image-guided cancer surgeries |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.768698/full |
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