Detection and clinical significance of anti-carbamylated protein antibody in serologically negative patients with rheumatoid arthritis
Objective To probe into the level and clinical significance of anti-carbamylated protein （CarP） antibody in serologically negative patients with rheumatoid arthritis （RA）. Methods A total of 301 RA patients and 55 healthy controls were recruited. Demographic characteristics and clinical data includi...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of New Medicine
2022-04-01
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| Series: | Xin yixue |
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| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1652688622455-1843864168.pdf |
| _version_ | 1811311173431197696 |
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| author | Wu Tao, Chen Chutao, Yang Lijuan, Zou Yaowei, Ma Jianda, Xu Yanhui, Jia Lei, Dai Lie |
| author_facet | Wu Tao, Chen Chutao, Yang Lijuan, Zou Yaowei, Ma Jianda, Xu Yanhui, Jia Lei, Dai Lie |
| author_sort | Wu Tao, Chen Chutao, Yang Lijuan, Zou Yaowei, Ma Jianda, Xu Yanhui, Jia Lei, Dai Lie |
| collection | DOAJ |
| description | Objective To probe into the level and clinical significance of anti-carbamylated protein （CarP） antibody in serologically negative patients with rheumatoid arthritis （RA）. Methods A total of 301 RA patients and 55 healthy controls were recruited. Demographic characteristics and clinical data including serum levels of rheumatoid factor （RF） and anti-cyclic citrullinated peptide （CCP） antibody were collected. Serum levels of IgG anti-CarP antibody were determined by ELISA. Results According to the 95th percentile of the anti-CarP antibody level in 55 healthy controls, the ceiling of normal value was ≤31 U/mL. Among 301 RA patients, the positive rates of RF, anti-CCP antibody and anti-CarP antibody were 74.8% （225/301）, 75.1% （226/301） and 15.9% （48/301）, respectively. The positive rates of anti-CarP antibody were 19.7% （15/76） in RA patients with negative RF and 20.0% （15/75） in RA patients with negative anti-CCP antibody, respectively. In negative-RF RA patients, additional detection of anti-CCP antibody could reduce the percentage of serologically negative RA patients by 39.5% （30/76）. Additional detection of anti-CarP antibody could lower the percentage by 19.7% （15/76）. Additional detection of both anti-CCP antibody and anti-CarP antibody could decrease the percentage by 50.0% （38/76）. In serologically negative RA patients （negative for both RF and anti-CCP antibodies）, additional detection of anti-CarP antibody could lower the percentage of serologically negative RA patients by 17.4% （8/46）. Conclusion Additional detection of anti-CarP antibody has supplementary value for the diagnosis of serologically negative RA which is currently a difficult issue in clinical practice. |
| first_indexed | 2024-04-13T10:14:10Z |
| format | Article |
| id | doaj.art-8afe6558ee414c93bca5395a0f4bc1d6 |
| institution | Directory Open Access Journal |
| issn | 0253-9802 |
| language | zho |
| last_indexed | 2024-04-13T10:14:10Z |
| publishDate | 2022-04-01 |
| publisher | Editorial Office of Journal of New Medicine |
| record_format | Article |
| series | Xin yixue |
| spelling | doaj.art-8afe6558ee414c93bca5395a0f4bc1d62022-12-22T02:50:48ZzhoEditorial Office of Journal of New MedicineXin yixue0253-98022022-04-0153424324810.3969/j.issn.0253-9802.2022.04.004Detection and clinical significance of anti-carbamylated protein antibody in serologically negative patients with rheumatoid arthritisWu Tao, Chen Chutao, Yang Lijuan, Zou Yaowei, Ma Jianda, Xu Yanhui, Jia Lei, Dai Lie0Department of Rheumatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaObjective To probe into the level and clinical significance of anti-carbamylated protein （CarP） antibody in serologically negative patients with rheumatoid arthritis （RA）. Methods A total of 301 RA patients and 55 healthy controls were recruited. Demographic characteristics and clinical data including serum levels of rheumatoid factor （RF） and anti-cyclic citrullinated peptide （CCP） antibody were collected. Serum levels of IgG anti-CarP antibody were determined by ELISA. Results According to the 95th percentile of the anti-CarP antibody level in 55 healthy controls, the ceiling of normal value was ≤31 U/mL. Among 301 RA patients, the positive rates of RF, anti-CCP antibody and anti-CarP antibody were 74.8% （225/301）, 75.1% （226/301） and 15.9% （48/301）, respectively. The positive rates of anti-CarP antibody were 19.7% （15/76） in RA patients with negative RF and 20.0% （15/75） in RA patients with negative anti-CCP antibody, respectively. In negative-RF RA patients, additional detection of anti-CCP antibody could reduce the percentage of serologically negative RA patients by 39.5% （30/76）. Additional detection of anti-CarP antibody could lower the percentage by 19.7% （15/76）. Additional detection of both anti-CCP antibody and anti-CarP antibody could decrease the percentage by 50.0% （38/76）. In serologically negative RA patients （negative for both RF and anti-CCP antibodies）, additional detection of anti-CarP antibody could lower the percentage of serologically negative RA patients by 17.4% （8/46）. Conclusion Additional detection of anti-CarP antibody has supplementary value for the diagnosis of serologically negative RA which is currently a difficult issue in clinical practice.https://www.xinyixue.cn/fileup/0253-9802/PDF/1652688622455-1843864168.pdf|rheumatoid arthritis|anti-carbamylated protein antibody|rheumatoid factor|diagnosis|anti-cyclic citrullinated peptide antibody |
| spellingShingle | Wu Tao, Chen Chutao, Yang Lijuan, Zou Yaowei, Ma Jianda, Xu Yanhui, Jia Lei, Dai Lie Detection and clinical significance of anti-carbamylated protein antibody in serologically negative patients with rheumatoid arthritis Xin yixue |rheumatoid arthritis|anti-carbamylated protein antibody|rheumatoid factor|diagnosis|anti-cyclic citrullinated peptide antibody |
| title | Detection and clinical significance of anti-carbamylated protein antibody in serologically negative patients with rheumatoid arthritis |
| title_full | Detection and clinical significance of anti-carbamylated protein antibody in serologically negative patients with rheumatoid arthritis |
| title_fullStr | Detection and clinical significance of anti-carbamylated protein antibody in serologically negative patients with rheumatoid arthritis |
| title_full_unstemmed | Detection and clinical significance of anti-carbamylated protein antibody in serologically negative patients with rheumatoid arthritis |
| title_short | Detection and clinical significance of anti-carbamylated protein antibody in serologically negative patients with rheumatoid arthritis |
| title_sort | detection and clinical significance of anti carbamylated protein antibody in serologically negative patients with rheumatoid arthritis |
| topic | |rheumatoid arthritis|anti-carbamylated protein antibody|rheumatoid factor|diagnosis|anti-cyclic citrullinated peptide antibody |
| url | https://www.xinyixue.cn/fileup/0253-9802/PDF/1652688622455-1843864168.pdf |
| work_keys_str_mv | AT wutaochenchutaoyanglijuanzouyaoweimajiandaxuyanhuijialeidailie detectionandclinicalsignificanceofanticarbamylatedproteinantibodyinserologicallynegativepatientswithrheumatoidarthritis |