Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea
Background: Chronic active EBV infection (CAEBV) of T-cell or NK-cell type is an EBV+ polyclonal, oligoclonal or often monoclonal lymphoproliferative disorder (LPD) recognized as representing the spectrum of EBV-associated T-cell and NK-cell LPD with different clinical presentations; one systemic an...
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| Format: | Article |
| Language: | English |
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Permanyer
2016-01-01
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| Series: | Boletín Médico del Hospital Infantil de México |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665114615002415 |
| _version_ | 1819276744974139392 |
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| author | Tae-Hee Lee Young-Hyeh Ko |
| author_facet | Tae-Hee Lee Young-Hyeh Ko |
| author_sort | Tae-Hee Lee |
| collection | DOAJ |
| description | Background: Chronic active EBV infection (CAEBV) of T-cell or NK-cell type is an EBV+ polyclonal, oligoclonal or often monoclonal lymphoproliferative disorder (LPD) recognized as representing the spectrum of EBV-associated T-cell and NK-cell LPD with different clinical presentations; one systemic and two cutaneous disorders including hydroa vacciniforme-like T-cell LPD and mosquito bite hypersensitivity. The systemic form of the disease is characterized by fever, persistent hepatitis, hepatosplenomegaly and lymphadenopathy, which shows varying degrees of clinical severity depending on the immune response of the host and the EBV viral load.
Case reports: We described the clinicopathological findings of two children with CAEBV with a brief review of the literature.
Conclusions: Recognition of the disease is important for adequate management of the patient. EBV analysis should be included in the principal diagnostic tests for febrile children. |
| first_indexed | 2024-12-23T23:45:06Z |
| format | Article |
| id | doaj.art-8b02073effc74fcabd8d9f1328779029 |
| institution | Directory Open Access Journal |
| issn | 1665-1146 |
| language | English |
| last_indexed | 2024-12-23T23:45:06Z |
| publishDate | 2016-01-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Boletín Médico del Hospital Infantil de México |
| spelling | doaj.art-8b02073effc74fcabd8d9f13287790292022-12-21T17:25:31ZengPermanyerBoletín Médico del Hospital Infantil de México1665-11462016-01-01731101710.1016/j.bmhimx.2015.12.003Chronic active EBV infection: the experience of the Samsung Medical Center in South KoreaTae-Hee LeeYoung-Hyeh KoBackground: Chronic active EBV infection (CAEBV) of T-cell or NK-cell type is an EBV+ polyclonal, oligoclonal or often monoclonal lymphoproliferative disorder (LPD) recognized as representing the spectrum of EBV-associated T-cell and NK-cell LPD with different clinical presentations; one systemic and two cutaneous disorders including hydroa vacciniforme-like T-cell LPD and mosquito bite hypersensitivity. The systemic form of the disease is characterized by fever, persistent hepatitis, hepatosplenomegaly and lymphadenopathy, which shows varying degrees of clinical severity depending on the immune response of the host and the EBV viral load. Case reports: We described the clinicopathological findings of two children with CAEBV with a brief review of the literature. Conclusions: Recognition of the disease is important for adequate management of the patient. EBV analysis should be included in the principal diagnostic tests for febrile children.http://www.sciencedirect.com/science/article/pii/S1665114615002415Epstein-Barr virusChildrenChronic active infectionNK lymphocytosisMosquito-bite hypersensitivity |
| spellingShingle | Tae-Hee Lee Young-Hyeh Ko Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea Boletín Médico del Hospital Infantil de México Epstein-Barr virus Children Chronic active infection NK lymphocytosis Mosquito-bite hypersensitivity |
| title | Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea |
| title_full | Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea |
| title_fullStr | Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea |
| title_full_unstemmed | Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea |
| title_short | Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea |
| title_sort | chronic active ebv infection the experience of the samsung medical center in south korea |
| topic | Epstein-Barr virus Children Chronic active infection NK lymphocytosis Mosquito-bite hypersensitivity |
| url | http://www.sciencedirect.com/science/article/pii/S1665114615002415 |
| work_keys_str_mv | AT taeheelee chronicactiveebvinfectiontheexperienceofthesamsungmedicalcenterinsouthkorea AT younghyehko chronicactiveebvinfectiontheexperienceofthesamsungmedicalcenterinsouthkorea |