Recent advances in understanding the phenotypes of osteoarthritis [version 1; peer review: 2 approved]
Recent research in the field of osteoarthritis (OA) has focused on understanding the underlying molecular and clinical phenotypes of the disease. This narrative review article focuses on recent advances in our understanding of the phenotypes of OA and proposes that the disease represents a diversity...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2019-12-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/8-2091/v1 |
| _version_ | 1818369371691548672 |
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| author | Ali Mobasheri Simo Saarakkala Mikko Finnilä Morten A. Karsdal Anne-Christine Bay-Jensen Willem Evert van Spil |
| author_facet | Ali Mobasheri Simo Saarakkala Mikko Finnilä Morten A. Karsdal Anne-Christine Bay-Jensen Willem Evert van Spil |
| author_sort | Ali Mobasheri |
| collection | DOAJ |
| description | Recent research in the field of osteoarthritis (OA) has focused on understanding the underlying molecular and clinical phenotypes of the disease. This narrative review article focuses on recent advances in our understanding of the phenotypes of OA and proposes that the disease represents a diversity of clinical phenotypes that are underpinned by a number of molecular mechanisms, which may be shared by several phenotypes and targeted more specifically for therapeutic purposes. The clinical phenotypes of OA supposedly have different underlying etiologies and pathogenic pathways and they progress at different rates. Large OA population cohorts consist of a majority of patients whose disease progresses slowly and a minority of individuals whose disease may progress faster. The ability to identify the people with relatively rapidly progressing OA can transform clinical trials and enhance their efficiency. The identification, characterization, and classification of molecular phenotypes of rapidly progressing OA, which represent patients who may benefit most from intervention, could potentially serve as the basis for precision medicine for this disabling condition. Imaging and biochemical markers (biomarkers) are important diagnostic and research tools that can assist with this challenge. |
| first_indexed | 2024-12-13T23:22:47Z |
| format | Article |
| id | doaj.art-8b029a169f9b4a95a501c131f38502eb |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-13T23:22:47Z |
| publishDate | 2019-12-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-8b029a169f9b4a95a501c131f38502eb2022-12-21T23:27:40ZengF1000 Research LtdF1000Research2046-14022019-12-01810.12688/f1000research.20575.122619Recent advances in understanding the phenotypes of osteoarthritis [version 1; peer review: 2 approved]Ali Mobasheri0Simo Saarakkala1Mikko Finnilä2Morten A. Karsdal3Anne-Christine Bay-Jensen4Willem Evert van Spil5Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, Queen’s Medical Centre, Nottingham, UKResearch Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, FI-90014, FinlandResearch Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, FI-90014, FinlandImmunoScience, Nordic Bioscience Biomarkers and Research, Herlev, DK-2730, DenmarkImmunoScience, Nordic Bioscience Biomarkers and Research, Herlev, DK-2730, DenmarkDivision of Internal Medicine & Dermatology, Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The NetherlandsRecent research in the field of osteoarthritis (OA) has focused on understanding the underlying molecular and clinical phenotypes of the disease. This narrative review article focuses on recent advances in our understanding of the phenotypes of OA and proposes that the disease represents a diversity of clinical phenotypes that are underpinned by a number of molecular mechanisms, which may be shared by several phenotypes and targeted more specifically for therapeutic purposes. The clinical phenotypes of OA supposedly have different underlying etiologies and pathogenic pathways and they progress at different rates. Large OA population cohorts consist of a majority of patients whose disease progresses slowly and a minority of individuals whose disease may progress faster. The ability to identify the people with relatively rapidly progressing OA can transform clinical trials and enhance their efficiency. The identification, characterization, and classification of molecular phenotypes of rapidly progressing OA, which represent patients who may benefit most from intervention, could potentially serve as the basis for precision medicine for this disabling condition. Imaging and biochemical markers (biomarkers) are important diagnostic and research tools that can assist with this challenge.https://f1000research.com/articles/8-2091/v1 |
| spellingShingle | Ali Mobasheri Simo Saarakkala Mikko Finnilä Morten A. Karsdal Anne-Christine Bay-Jensen Willem Evert van Spil Recent advances in understanding the phenotypes of osteoarthritis [version 1; peer review: 2 approved] F1000Research |
| title | Recent advances in understanding the phenotypes of osteoarthritis [version 1; peer review: 2 approved] |
| title_full | Recent advances in understanding the phenotypes of osteoarthritis [version 1; peer review: 2 approved] |
| title_fullStr | Recent advances in understanding the phenotypes of osteoarthritis [version 1; peer review: 2 approved] |
| title_full_unstemmed | Recent advances in understanding the phenotypes of osteoarthritis [version 1; peer review: 2 approved] |
| title_short | Recent advances in understanding the phenotypes of osteoarthritis [version 1; peer review: 2 approved] |
| title_sort | recent advances in understanding the phenotypes of osteoarthritis version 1 peer review 2 approved |
| url | https://f1000research.com/articles/8-2091/v1 |
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