The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response

The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response

We have previously shown that the microRNA (miRNA) processor complex consisting of the RNAse Drosha and the DiGeorge Critical Region (DGCR) 8 protein is essential for B cell maturation. To determine whether miRNA processing is required to initiate T cell-mediated antibody responses, we deleted DGCR8...

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Bibliographic Details
Main Authors: Patrick Daum, Shannon R. Ottmann, Julia Meinzinger, Sebastian R. Schulz, Joana Côrte-Real, Manuela Hauke, Edith Roth, Wolfgang Schuh, Dirk Mielenz, Hans-Martin Jäck, Katharina Pracht
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
DGCR8
DiGeorge syndrome critical region 8 protein
microRNA
B1 cell
plasma cell (PC)
antibody-secreting cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.991347/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.991347/full

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