The roles of glucose metabolic reprogramming in chemo- and radio-resistance
Abstract Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which is vital to maintain rapid cell proliferation, tumor progression, and resistance t...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-05-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13046-019-1214-z |
| _version_ | 1818351571843416064 |
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| author | Jinguan Lin Longzheng Xia Jiaxin Liang Yaqian Han Heran Wang Linda Oyang Shiming Tan Yutong Tian Shan Rao Xiaoyan Chen Yanyan Tang Min Su Xia Luo Ying Wang Hui Wang Yujuan Zhou Qianjin Liao |
| author_facet | Jinguan Lin Longzheng Xia Jiaxin Liang Yaqian Han Heran Wang Linda Oyang Shiming Tan Yutong Tian Shan Rao Xiaoyan Chen Yanyan Tang Min Su Xia Luo Ying Wang Hui Wang Yujuan Zhou Qianjin Liao |
| author_sort | Jinguan Lin |
| collection | DOAJ |
| description | Abstract Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which is vital to maintain rapid cell proliferation, tumor progression, and resistance to chemotherapy and radiation. When the glucose metabolism of cancer is rewiring, the characters of cancer will also occur corresponding changes to regulate the chemo- and radio-resistance of cancer. The procedure is involved in the alteration of many activities, such as the aberrant DNA repairing, enhanced autophagy, oxygen-deficient environment, and increasing exosomes secretions, etc. Targeting altered metabolic pathways related with the glucose metabolism has become a promising anti-cancer strategy. This review summarizes recent progress in our understanding of glucose metabolism in chemo- and radio-resistance malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment. |
| first_indexed | 2024-12-13T18:39:52Z |
| format | Article |
| id | doaj.art-8b04269ded8742ac9f1b4c9ce32a60ca |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-12-13T18:39:52Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-8b04269ded8742ac9f1b4c9ce32a60ca2022-12-21T23:35:15ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662019-05-0138111310.1186/s13046-019-1214-zThe roles of glucose metabolic reprogramming in chemo- and radio-resistanceJinguan Lin0Longzheng Xia1Jiaxin Liang2Yaqian Han3Heran Wang4Linda Oyang5Shiming Tan6Yutong Tian7Shan Rao8Xiaoyan Chen9Yanyan Tang10Min Su11Xia Luo12Ying Wang13Hui Wang14Yujuan Zhou15Qianjin Liao16The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyThe Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation OncologyAbstract Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which is vital to maintain rapid cell proliferation, tumor progression, and resistance to chemotherapy and radiation. When the glucose metabolism of cancer is rewiring, the characters of cancer will also occur corresponding changes to regulate the chemo- and radio-resistance of cancer. The procedure is involved in the alteration of many activities, such as the aberrant DNA repairing, enhanced autophagy, oxygen-deficient environment, and increasing exosomes secretions, etc. Targeting altered metabolic pathways related with the glucose metabolism has become a promising anti-cancer strategy. This review summarizes recent progress in our understanding of glucose metabolism in chemo- and radio-resistance malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment.http://link.springer.com/article/10.1186/s13046-019-1214-zMetabolic reprogrammingChemo-resistanceRadio-resistanceTME |
| spellingShingle | Jinguan Lin Longzheng Xia Jiaxin Liang Yaqian Han Heran Wang Linda Oyang Shiming Tan Yutong Tian Shan Rao Xiaoyan Chen Yanyan Tang Min Su Xia Luo Ying Wang Hui Wang Yujuan Zhou Qianjin Liao The roles of glucose metabolic reprogramming in chemo- and radio-resistance Journal of Experimental & Clinical Cancer Research Metabolic reprogramming Chemo-resistance Radio-resistance TME |
| title | The roles of glucose metabolic reprogramming in chemo- and radio-resistance |
| title_full | The roles of glucose metabolic reprogramming in chemo- and radio-resistance |
| title_fullStr | The roles of glucose metabolic reprogramming in chemo- and radio-resistance |
| title_full_unstemmed | The roles of glucose metabolic reprogramming in chemo- and radio-resistance |
| title_short | The roles of glucose metabolic reprogramming in chemo- and radio-resistance |
| title_sort | roles of glucose metabolic reprogramming in chemo and radio resistance |
| topic | Metabolic reprogramming Chemo-resistance Radio-resistance TME |
| url | http://link.springer.com/article/10.1186/s13046-019-1214-z |
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