Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis

Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis

Abstract Hepatocarcinogenesis is initiated by repeated hepatocyte death and liver damage, and the underlying mechanisms mediating cell death and the subsequent carcinogenesis remain to be fully investigated. Immunoresponsive gene 1 (IRG1) and its enzymatic metabolite itaconate are known to suppress...

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Bibliographic Details
Main Authors: Liyuan Zhang, Yue Dong, Luxin Zhang, Minjun Wang, Ye Zhou, Kaiwei Jia, Suyuan Wang, Mu Wang, Yunhui Li, Shudan Luo, Shan Lu, Yiwen Fan, Dingji Zhang, Yingyun Yang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06155-7

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