The paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectotherms
Summary: Amphibians, like the paddy frog (Fejervarya multistriata), have played a critical role in the transition from water to land. Hibernation is a vital survival adaptation in cold environments with limited food resources. We decoded the paddy frog genome to reveal the molecular adaptations link...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224000658 |
| _version_ | 1797352636085698560 |
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| author | Yunyun Lv Chuan Chen Chengzhi Yan Wenbo Liao |
| author_facet | Yunyun Lv Chuan Chen Chengzhi Yan Wenbo Liao |
| author_sort | Yunyun Lv |
| collection | DOAJ |
| description | Summary: Amphibians, like the paddy frog (Fejervarya multistriata), have played a critical role in the transition from water to land. Hibernation is a vital survival adaptation in cold environments with limited food resources. We decoded the paddy frog genome to reveal the molecular adaptations linked to hibernation in ectotherms. The genome contained 13 chromosomes, with a significant proportion of repetitive sequences. We identified the key genes encoding the proteins of AANAT, TRPM8, EGLN1, and VEGFA essential for circadian rhythms, thermosensation, and hypoxia during hibernation by comparing the hibernator and non-hibernator genomes. Examining organ changes during hibernation revealed the central regulatory role of the brain. We identified 21 factors contributing to hibernation, involving hormone biosynthesis, protein digestion, DNA replication, and the cell cycle. These findings provide deeper insight into the complex mechanisms of ectothermic hibernation and contribute to our understanding of the broader significance of this evolutionary adaptation. |
| first_indexed | 2024-03-08T13:19:47Z |
| format | Article |
| id | doaj.art-8b06d4dd96314d2ba032a9f0e3d9a918 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T13:19:47Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-8b06d4dd96314d2ba032a9f0e3d9a9182024-01-18T04:18:24ZengElsevieriScience2589-00422024-02-01272108844The paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectothermsYunyun Lv0Chuan Chen1Chengzhi Yan2Wenbo Liao3Key Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), China West Normal University, Nanchong, Sichuan 637009, China; Key Laboratory of Sichuan Province for Fishes Conservation and Utilization in the Upper Reaches of the Yangtze River, College of Life Science, Neijiang Normal University, Neijiang 641100, ChinaKey Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), China West Normal University, Nanchong, Sichuan 637009, ChinaKey Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), China West Normal University, Nanchong, Sichuan 637009, ChinaKey Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), China West Normal University, Nanchong, Sichuan 637009, China; College of Panda, China West Normal Univetsity, Nanchong, Sichuan 637009, China; Corresponding authorSummary: Amphibians, like the paddy frog (Fejervarya multistriata), have played a critical role in the transition from water to land. Hibernation is a vital survival adaptation in cold environments with limited food resources. We decoded the paddy frog genome to reveal the molecular adaptations linked to hibernation in ectotherms. The genome contained 13 chromosomes, with a significant proportion of repetitive sequences. We identified the key genes encoding the proteins of AANAT, TRPM8, EGLN1, and VEGFA essential for circadian rhythms, thermosensation, and hypoxia during hibernation by comparing the hibernator and non-hibernator genomes. Examining organ changes during hibernation revealed the central regulatory role of the brain. We identified 21 factors contributing to hibernation, involving hormone biosynthesis, protein digestion, DNA replication, and the cell cycle. These findings provide deeper insight into the complex mechanisms of ectothermic hibernation and contribute to our understanding of the broader significance of this evolutionary adaptation.http://www.sciencedirect.com/science/article/pii/S2589004224000658PhysiologyGeneticsMolecular biology |
| spellingShingle | Yunyun Lv Chuan Chen Chengzhi Yan Wenbo Liao The paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectotherms iScience Physiology Genetics Molecular biology |
| title | The paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectotherms |
| title_full | The paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectotherms |
| title_fullStr | The paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectotherms |
| title_full_unstemmed | The paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectotherms |
| title_short | The paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectotherms |
| title_sort | paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectotherms |
| topic | Physiology Genetics Molecular biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224000658 |
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