Which one is the real matchmaker for the pair?
A fundamental question for meiosis is how homologous chromosomes (homologs) find each other and pair together to ensure homologous recombination and segregation. Intuitively, the answer to the question is related to the interaction between homologous sequences. However, that is not the whole story a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-10-01
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| Series: | Asian Journal of Andrology |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=5;spage=667;epage=668;aulast=Han |
| _version_ | 1819062332291022848 |
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| author | Chunsheng Han |
| author_facet | Chunsheng Han |
| author_sort | Chunsheng Han |
| collection | DOAJ |
| description | A fundamental question for meiosis is how homologous chromosomes (homologs) find each other and pair together to ensure homologous recombination and segregation. Intuitively, the answer to the question is related to the interaction between homologous sequences. However, that is not the whole story according to some studies on the role of cohesins in homolog pairing. The most recent one by Ishiguro et al.[1] of the Watanabe group indicates that chromosome architecture defined by a meiosis-specific cohesin protein RAD21L is the key to homology searching. Moreover, they report that homologous pairing is dependent on neither SPO11, an evolutionarily conserved type 2 isomerase responsible for generating DNA double-strand breaks (DSBs), nor SUN1, which tethers the ends of chromosomes to the nuclear envelop (NE) and facilitates chromosome movement and bouquet formation. These discoveries are quite some surprises! |
| first_indexed | 2024-12-21T14:57:06Z |
| format | Article |
| id | doaj.art-8b0735b7afdb487cba5063ff45a93c1c |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-21T14:57:06Z |
| publishDate | 2014-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-8b0735b7afdb487cba5063ff45a93c1c2022-12-21T18:59:44ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622014-10-0116566766810.4103/1008-682X.133316Which one is the real matchmaker for the pair? Chunsheng HanA fundamental question for meiosis is how homologous chromosomes (homologs) find each other and pair together to ensure homologous recombination and segregation. Intuitively, the answer to the question is related to the interaction between homologous sequences. However, that is not the whole story according to some studies on the role of cohesins in homolog pairing. The most recent one by Ishiguro et al.[1] of the Watanabe group indicates that chromosome architecture defined by a meiosis-specific cohesin protein RAD21L is the key to homology searching. Moreover, they report that homologous pairing is dependent on neither SPO11, an evolutionarily conserved type 2 isomerase responsible for generating DNA double-strand breaks (DSBs), nor SUN1, which tethers the ends of chromosomes to the nuclear envelop (NE) and facilitates chromosome movement and bouquet formation. These discoveries are quite some surprises!http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=5;spage=667;epage=668;aulast=Han |
| spellingShingle | Chunsheng Han Which one is the real matchmaker for the pair? Asian Journal of Andrology |
| title | Which one is the real matchmaker for the pair? |
| title_full | Which one is the real matchmaker for the pair? |
| title_fullStr | Which one is the real matchmaker for the pair? |
| title_full_unstemmed | Which one is the real matchmaker for the pair? |
| title_short | Which one is the real matchmaker for the pair? |
| title_sort | which one is the real matchmaker for the pair |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=5;spage=667;epage=668;aulast=Han |
| work_keys_str_mv | AT chunshenghan whichoneistherealmatchmakerforthepair |