Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival
Background/Methods: This study determines the co-expression of mammaglobin-A, vascular endothelial growth factor receptor-3 (VEGFR3) and Ki67 by immunohistochemistry (IHC) in tissue samples from 80 patients undergoing breast surgery (cancer or benign disease). The tissue expression was compared with...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-06-01
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| Series: | Breast Cancer: Basic and Clinical Research |
| Online Access: | https://doi.org/10.1177/1178223419858957 |
| _version_ | 1819008653732085760 |
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| author | Elizabeth Baker Naomi Whiteoak Louise Hall James France Deborah Wilson Pudupalayam Bhaskar |
| author_facet | Elizabeth Baker Naomi Whiteoak Louise Hall James France Deborah Wilson Pudupalayam Bhaskar |
| author_sort | Elizabeth Baker |
| collection | DOAJ |
| description | Background/Methods: This study determines the co-expression of mammaglobin-A, vascular endothelial growth factor receptor-3 (VEGFR3) and Ki67 by immunohistochemistry (IHC) in tissue samples from 80 patients undergoing breast surgery (cancer or benign disease). The tissue expression was compared with the tumour histopathology and Kaplan Meier 5-year survival analysis was performed. Results: Positive breast tissue expression was observed in 53% samples for mammaglobin, 41% Ki67 and 65% VEGFR3 with a significant positive correlation between Ki67 and VEGFR3 co-expression. Ki67 and VEGFR3 expression correlated with the breast tumour grade and Ki67 expression also correlated with oestrogen receptor (ER) status. At 5 years post-operatively, 6/80 patients had died and 3 patients were alive but had cancer recurrence. High Ki67 expression significantly correlated with poor survival (disease-free and overall). Conclusions: In this study, VEGFR3 and Ki67 expression but not mammaglobin-A correlated with breast tumour pathology. Positive Ki67 expression was also associated with a poor 5-year survival outcome. |
| first_indexed | 2024-12-21T00:43:54Z |
| format | Article |
| id | doaj.art-8b0895052f6646ed9d62a9bcde01a902 |
| institution | Directory Open Access Journal |
| issn | 1178-2234 |
| language | English |
| last_indexed | 2024-12-21T00:43:54Z |
| publishDate | 2019-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Breast Cancer: Basic and Clinical Research |
| spelling | doaj.art-8b0895052f6646ed9d62a9bcde01a9022022-12-21T19:21:35ZengSAGE PublishingBreast Cancer: Basic and Clinical Research1178-22342019-06-011310.1177/1178223419858957Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year SurvivalElizabeth Baker0Naomi Whiteoak1Louise Hall2James France3Deborah Wilson4Pudupalayam Bhaskar5Department of Surgery, University Hospital of North Tees, Stockton on Tees, UKDepartment of Histopathology, University Hospital of North Tees, Stockton on Tees, UKDepartment of Histopathology, University Hospital of North Tees, Stockton on Tees, UKDepartment of Histopathology, University Hospital of North Tees, Stockton on Tees, UKDepartment of Surgery, University Hospital of North Tees, Stockton on Tees, UKDepartment of Surgery, University Hospital of North Tees, Stockton on Tees, UKBackground/Methods: This study determines the co-expression of mammaglobin-A, vascular endothelial growth factor receptor-3 (VEGFR3) and Ki67 by immunohistochemistry (IHC) in tissue samples from 80 patients undergoing breast surgery (cancer or benign disease). The tissue expression was compared with the tumour histopathology and Kaplan Meier 5-year survival analysis was performed. Results: Positive breast tissue expression was observed in 53% samples for mammaglobin, 41% Ki67 and 65% VEGFR3 with a significant positive correlation between Ki67 and VEGFR3 co-expression. Ki67 and VEGFR3 expression correlated with the breast tumour grade and Ki67 expression also correlated with oestrogen receptor (ER) status. At 5 years post-operatively, 6/80 patients had died and 3 patients were alive but had cancer recurrence. High Ki67 expression significantly correlated with poor survival (disease-free and overall). Conclusions: In this study, VEGFR3 and Ki67 expression but not mammaglobin-A correlated with breast tumour pathology. Positive Ki67 expression was also associated with a poor 5-year survival outcome.https://doi.org/10.1177/1178223419858957 |
| spellingShingle | Elizabeth Baker Naomi Whiteoak Louise Hall James France Deborah Wilson Pudupalayam Bhaskar Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival Breast Cancer: Basic and Clinical Research |
| title | Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival |
| title_full | Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival |
| title_fullStr | Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival |
| title_full_unstemmed | Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival |
| title_short | Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival |
| title_sort | mammaglobin a vegfr3 and ki67 in human breast cancer pathology and five year survival |
| url | https://doi.org/10.1177/1178223419858957 |
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