Delaying age at first sexual intercourse provides protection against oral cavity cancer: a mendelian randomization study
AimTo investigate whether age at first sexual intercourse could lead to any changes in the risk of oral cavity cancer.MethodsA two-sample mendelian randomization was conducted using genetic variants associated with age at first sexual intercourse in UK biobank as instrumental variables. Summary data...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1361527/full |
| _version_ | 1797202054564806656 |
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| author | Ting Sun Xin He Xing Chen Xing Chen Yang Huaqing Haimei Zhang Min Zhao Li Du Bin Zhao Junping Hou Xudong Li Yu Liu |
| author_facet | Ting Sun Xin He Xing Chen Xing Chen Yang Huaqing Haimei Zhang Min Zhao Li Du Bin Zhao Junping Hou Xudong Li Yu Liu |
| author_sort | Ting Sun |
| collection | DOAJ |
| description | AimTo investigate whether age at first sexual intercourse could lead to any changes in the risk of oral cavity cancer.MethodsA two-sample mendelian randomization was conducted using genetic variants associated with age at first sexual intercourse in UK biobank as instrumental variables. Summary data of Northern American from a previous genome-wide association study aimed at oral cavity cancer was served as outcome. Three analytical methods: inverse variance-weighted, mendelian randomization Egger, and weighted median were used to perform the analysis, among which inverse variance-weighted was set as the primary method. Robustness of the results was assessed through Cochran Q test, mendelian randomization Egger intercept tests, MR PRESSO, leave one out analysis and funnel plot.ResultsThe primary analysis provided substantial evidence of a positive causal relationship age at first sexual intercourse and the risk of oral cavity cancer (p = 0.0002), while a delayed age at first sexual intercourse would lead to a decreased risk of suffering oral cavity cancer (β = -1.013). The secondary outcomes confirmed the results (all β < 0) and all assessments supported the robustness, too (all p > 0.05).ConclusionThe study demonstrates that a delayed sexual debut would provide protection against OCC, thus education on delaying sexual intercourse should be recommended. |
| first_indexed | 2024-04-24T07:57:20Z |
| format | Article |
| id | doaj.art-8b09575a278647eeaa53455593b1a2a4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T07:57:20Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8b09575a278647eeaa53455593b1a2a42024-04-18T04:46:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-04-011410.3389/fonc.2024.13615271361527Delaying age at first sexual intercourse provides protection against oral cavity cancer: a mendelian randomization studyTing Sun0Xin He1Xing Chen2Xing Chen3Yang Huaqing4Haimei Zhang5Min Zhao6Li Du7Bin Zhao8Junping Hou9Xudong Li10Yu Liu11Department of Oncology, Guangyuan Central Hospital, Guangyuan, ChinaDepartment of Emergency, Guangyuan Central Hospital, Guangyuan, ChinaDepartment of Dentistry and Oral Surgery, Guangyuan Central Hospital, Guangyuan, ChinaDepartment of Dentistry and Oral Surgery, North Sichuan Medical College, Nanchong, ChinaDepartment of Oncology, Guangyuan Central Hospital, Guangyuan, ChinaDepartment of Dentistry and Oral Surgery, Guangyuan Central Hospital, Guangyuan, ChinaDepartment of Oncology, Guangyuan Central Hospital, Guangyuan, ChinaDepartment of Oncology, Guangyuan Central Hospital, Guangyuan, ChinaDepartment of Oncology, Guangyuan Central Hospital, Guangyuan, ChinaDepartment of Oncology, Guangyuan Central Hospital, Guangyuan, ChinaDepartment of Oncology, Guangyuan Central Hospital, Guangyuan, ChinaDepartment of Oncology, Guangyuan Central Hospital, Guangyuan, ChinaAimTo investigate whether age at first sexual intercourse could lead to any changes in the risk of oral cavity cancer.MethodsA two-sample mendelian randomization was conducted using genetic variants associated with age at first sexual intercourse in UK biobank as instrumental variables. Summary data of Northern American from a previous genome-wide association study aimed at oral cavity cancer was served as outcome. Three analytical methods: inverse variance-weighted, mendelian randomization Egger, and weighted median were used to perform the analysis, among which inverse variance-weighted was set as the primary method. Robustness of the results was assessed through Cochran Q test, mendelian randomization Egger intercept tests, MR PRESSO, leave one out analysis and funnel plot.ResultsThe primary analysis provided substantial evidence of a positive causal relationship age at first sexual intercourse and the risk of oral cavity cancer (p = 0.0002), while a delayed age at first sexual intercourse would lead to a decreased risk of suffering oral cavity cancer (β = -1.013). The secondary outcomes confirmed the results (all β < 0) and all assessments supported the robustness, too (all p > 0.05).ConclusionThe study demonstrates that a delayed sexual debut would provide protection against OCC, thus education on delaying sexual intercourse should be recommended.https://www.frontiersin.org/articles/10.3389/fonc.2024.1361527/fulloral cavity cancerMendelian randomizationsexual intercourseepidemiologymalignant tumor |
| spellingShingle | Ting Sun Xin He Xing Chen Xing Chen Yang Huaqing Haimei Zhang Min Zhao Li Du Bin Zhao Junping Hou Xudong Li Yu Liu Delaying age at first sexual intercourse provides protection against oral cavity cancer: a mendelian randomization study Frontiers in Oncology oral cavity cancer Mendelian randomization sexual intercourse epidemiology malignant tumor |
| title | Delaying age at first sexual intercourse provides protection against oral cavity cancer: a mendelian randomization study |
| title_full | Delaying age at first sexual intercourse provides protection against oral cavity cancer: a mendelian randomization study |
| title_fullStr | Delaying age at first sexual intercourse provides protection against oral cavity cancer: a mendelian randomization study |
| title_full_unstemmed | Delaying age at first sexual intercourse provides protection against oral cavity cancer: a mendelian randomization study |
| title_short | Delaying age at first sexual intercourse provides protection against oral cavity cancer: a mendelian randomization study |
| title_sort | delaying age at first sexual intercourse provides protection against oral cavity cancer a mendelian randomization study |
| topic | oral cavity cancer Mendelian randomization sexual intercourse epidemiology malignant tumor |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1361527/full |
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