Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease

Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease

Abstract The development of a cerebral organoid culture in vitro offers an opportunity to generate human brain-like organs to investigate mechanisms of human disease that are specific to the neurogenesis of radial glial (RG) and outer radial glial (oRG) cells in the ventricular zone (VZ) and subvent...

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Bibliographic Details
Main Authors: Rui Li, Le Sun, Ai Fang, Peng Li, Qian Wu, Xiaoqun Wang
Format: Article
Language:English
Published: Oxford University Press 2017-10-01
Series:Protein & Cell
Subjects:
neocortical development
cerebral organoid
microcephaly
ASPM
Online Access:http://link.springer.com/article/10.1007/s13238-017-0479-2

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http://link.springer.com/article/10.1007/s13238-017-0479-2

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