Exosomes in Cancer: Diagnostic and Therapeutic Applications
Small extracellular vesicles called exosomes are produced by cells and contain a range of biomolecules, including proteins, lipids, and nucleic acids. Exosomes have been implicated in the development and spread of cancer, and recent studies have shown that their contents may be exploited as biomarke...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-01-01
|
| Series: | Clinical Medicine Insights: Oncology |
| Online Access: | https://doi.org/10.1177/11795549231215966 |
| _version_ | 1797350750367514624 |
|---|---|
| author | Quratulain Maqsood Aleena Sumrin Yasar Saleem Abdul Wajid Muhammada Mahnoor |
| author_facet | Quratulain Maqsood Aleena Sumrin Yasar Saleem Abdul Wajid Muhammada Mahnoor |
| author_sort | Quratulain Maqsood |
| collection | DOAJ |
| description | Small extracellular vesicles called exosomes are produced by cells and contain a range of biomolecules, including proteins, lipids, and nucleic acids. Exosomes have been implicated in the development and spread of cancer, and recent studies have shown that their contents may be exploited as biomarkers for early detection and ongoing surveillance of the disease. In this review article, we summarize the current knowledge on exosomes as biomarkers of cancer. We discuss the various methods used for exosome isolation and characterization, as well as the different types of biomolecules found within exosomes that are relevant for cancer diagnosis and prognosis. We also highlight recent studies that have demonstrated the utility of exosomal biomarkers in different types of cancer, such as lung cancer, breast cancer, and pancreatic cancer. Overall, exosomes show great promise as noninvasive biomarkers for cancer detection and monitoring. Exosomes have the ability to transform cancer diagnostic and therapeutic paradigms, providing promise for more efficient and individualized. This review seeks to serve as an inspiration for new ideas and research in the never-ending fight against cancer. Moreover, further studies are needed to validate their clinical utility and establish standardized protocols for their isolation and analysis. With continued research and development, exosomal biomarkers have the potential to revolutionize cancer diagnosis and treatment. |
| first_indexed | 2024-03-08T12:49:15Z |
| format | Article |
| id | doaj.art-8b0b619e923b4372ad58d810979504d0 |
| institution | Directory Open Access Journal |
| issn | 1179-5549 |
| language | English |
| last_indexed | 2024-03-08T12:49:15Z |
| publishDate | 2024-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Oncology |
| spelling | doaj.art-8b0b619e923b4372ad58d810979504d02024-01-20T11:03:23ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492024-01-011810.1177/11795549231215966Exosomes in Cancer: Diagnostic and Therapeutic ApplicationsQuratulain Maqsood0Aleena Sumrin1Yasar Saleem2Abdul Wajid3Muhammada Mahnoor4Department of Centre for Applied Molecular Biology, University of the Punjab, Lahore, PakistanDepartment of Centre for Applied Molecular Biology, University of the Punjab, Lahore, PakistanDepartment of Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex Lahore, Lahore, PakistanDepartment of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, PakistanDepartment of Rehabilitation Science, The University of Lahore, Lahore, PakistanSmall extracellular vesicles called exosomes are produced by cells and contain a range of biomolecules, including proteins, lipids, and nucleic acids. Exosomes have been implicated in the development and spread of cancer, and recent studies have shown that their contents may be exploited as biomarkers for early detection and ongoing surveillance of the disease. In this review article, we summarize the current knowledge on exosomes as biomarkers of cancer. We discuss the various methods used for exosome isolation and characterization, as well as the different types of biomolecules found within exosomes that are relevant for cancer diagnosis and prognosis. We also highlight recent studies that have demonstrated the utility of exosomal biomarkers in different types of cancer, such as lung cancer, breast cancer, and pancreatic cancer. Overall, exosomes show great promise as noninvasive biomarkers for cancer detection and monitoring. Exosomes have the ability to transform cancer diagnostic and therapeutic paradigms, providing promise for more efficient and individualized. This review seeks to serve as an inspiration for new ideas and research in the never-ending fight against cancer. Moreover, further studies are needed to validate their clinical utility and establish standardized protocols for their isolation and analysis. With continued research and development, exosomal biomarkers have the potential to revolutionize cancer diagnosis and treatment.https://doi.org/10.1177/11795549231215966 |
| spellingShingle | Quratulain Maqsood Aleena Sumrin Yasar Saleem Abdul Wajid Muhammada Mahnoor Exosomes in Cancer: Diagnostic and Therapeutic Applications Clinical Medicine Insights: Oncology |
| title | Exosomes in Cancer: Diagnostic and Therapeutic Applications |
| title_full | Exosomes in Cancer: Diagnostic and Therapeutic Applications |
| title_fullStr | Exosomes in Cancer: Diagnostic and Therapeutic Applications |
| title_full_unstemmed | Exosomes in Cancer: Diagnostic and Therapeutic Applications |
| title_short | Exosomes in Cancer: Diagnostic and Therapeutic Applications |
| title_sort | exosomes in cancer diagnostic and therapeutic applications |
| url | https://doi.org/10.1177/11795549231215966 |
| work_keys_str_mv | AT quratulainmaqsood exosomesincancerdiagnosticandtherapeuticapplications AT aleenasumrin exosomesincancerdiagnosticandtherapeuticapplications AT yasarsaleem exosomesincancerdiagnosticandtherapeuticapplications AT abdulwajid exosomesincancerdiagnosticandtherapeuticapplications AT muhammadamahnoor exosomesincancerdiagnosticandtherapeuticapplications |