Low-Cost Predictors for Liver Function and Clinical Outcomes after Sustained Virological Response in Patients with HCV-Related Cirrhosis and Thrombocytopenia
<i>Background and Objectives</i>: To find low-cost markers that can identify the hepatitis C virus cirrhotic patients that are at risk for long-term severe adverse liver effects (ascites, ascites or upper gastrointestinal bleeding, hepatocellular carcinoma), after treatment. There is est...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/1/146 |
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| author | Secil Omer Adrian Iftime Ileana Constantinescu Ion Dina |
| author_facet | Secil Omer Adrian Iftime Ileana Constantinescu Ion Dina |
| author_sort | Secil Omer |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: To find low-cost markers that can identify the hepatitis C virus cirrhotic patients that are at risk for long-term severe adverse liver effects (ascites, ascites or upper gastrointestinal bleeding, hepatocellular carcinoma), after treatment. There is established evidence for the benefits of treating hepatitis C virus cirrhotic patients, but there is still some need for clarification concerning the real impact on the long-term evolution after achieving sustained virological response; there is no general consensus in the literature about identifying the patients that do not improve post-treatment. <i>Materials and Methods</i>: Our retrospective analysis investigated the long-term (2 years) evolution of 46 patients with cirrhosis with thrombocytopenia, previously infected with VHC, treated and who obtained an SVR after DAA treatment. <i>Results</i>: Despite the overall improvement, 8.7% patients developed hepatocellular carcinoma and 6.5% patients ascites/upper GI bleeding. We found that FIB-4, MELD and AFP changes at 1 year were the most significant predictors for these outcomes. Additionally, a drop in leukocyte count after 1 year seemed to indicate a risk for hepatocellular carcinoma, but this was not consistent. <i>Conclusions</i>: It might be beneficial to intensify the surveillance for post-treatment adverse liver effects for the patients with these marker changes at 1 year. |
| first_indexed | 2024-03-09T11:44:36Z |
| format | Article |
| id | doaj.art-8b0eb71333c5418ab692ed34ee314102 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T11:44:36Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-8b0eb71333c5418ab692ed34ee3141022023-11-30T23:25:00ZengMDPI AGMedicina1010-660X1648-91442023-01-0159114610.3390/medicina59010146Low-Cost Predictors for Liver Function and Clinical Outcomes after Sustained Virological Response in Patients with HCV-Related Cirrhosis and ThrombocytopeniaSecil Omer0Adrian Iftime1Ileana Constantinescu2Ion Dina3Department of Medical Semiology, Saint Joan Hospital Bucharest, Carol Davila University of Medicine, 042122 Bucharest, RomaniaDepartment of Biophysics, Carol Davila University of Medicine, 050474 Bucharest, RomaniaDepartment of Immunology and Transplant Immunology, Fundeni Clinical Institute Bucharest, Carol Davila University of Medicine, 022328 Bucharest, RomaniaDepartment of Medical Semiology, Saint Joan Hospital Bucharest, Carol Davila University of Medicine, 042122 Bucharest, Romania<i>Background and Objectives</i>: To find low-cost markers that can identify the hepatitis C virus cirrhotic patients that are at risk for long-term severe adverse liver effects (ascites, ascites or upper gastrointestinal bleeding, hepatocellular carcinoma), after treatment. There is established evidence for the benefits of treating hepatitis C virus cirrhotic patients, but there is still some need for clarification concerning the real impact on the long-term evolution after achieving sustained virological response; there is no general consensus in the literature about identifying the patients that do not improve post-treatment. <i>Materials and Methods</i>: Our retrospective analysis investigated the long-term (2 years) evolution of 46 patients with cirrhosis with thrombocytopenia, previously infected with VHC, treated and who obtained an SVR after DAA treatment. <i>Results</i>: Despite the overall improvement, 8.7% patients developed hepatocellular carcinoma and 6.5% patients ascites/upper GI bleeding. We found that FIB-4, MELD and AFP changes at 1 year were the most significant predictors for these outcomes. Additionally, a drop in leukocyte count after 1 year seemed to indicate a risk for hepatocellular carcinoma, but this was not consistent. <i>Conclusions</i>: It might be beneficial to intensify the surveillance for post-treatment adverse liver effects for the patients with these marker changes at 1 year.https://www.mdpi.com/1648-9144/59/1/146hepatitis C viruscirrhosisthrombocytopeniahepatocellular carcinomaascitesgastrointestinal bleeding |
| spellingShingle | Secil Omer Adrian Iftime Ileana Constantinescu Ion Dina Low-Cost Predictors for Liver Function and Clinical Outcomes after Sustained Virological Response in Patients with HCV-Related Cirrhosis and Thrombocytopenia Medicina hepatitis C virus cirrhosis thrombocytopenia hepatocellular carcinoma ascites gastrointestinal bleeding |
| title | Low-Cost Predictors for Liver Function and Clinical Outcomes after Sustained Virological Response in Patients with HCV-Related Cirrhosis and Thrombocytopenia |
| title_full | Low-Cost Predictors for Liver Function and Clinical Outcomes after Sustained Virological Response in Patients with HCV-Related Cirrhosis and Thrombocytopenia |
| title_fullStr | Low-Cost Predictors for Liver Function and Clinical Outcomes after Sustained Virological Response in Patients with HCV-Related Cirrhosis and Thrombocytopenia |
| title_full_unstemmed | Low-Cost Predictors for Liver Function and Clinical Outcomes after Sustained Virological Response in Patients with HCV-Related Cirrhosis and Thrombocytopenia |
| title_short | Low-Cost Predictors for Liver Function and Clinical Outcomes after Sustained Virological Response in Patients with HCV-Related Cirrhosis and Thrombocytopenia |
| title_sort | low cost predictors for liver function and clinical outcomes after sustained virological response in patients with hcv related cirrhosis and thrombocytopenia |
| topic | hepatitis C virus cirrhosis thrombocytopenia hepatocellular carcinoma ascites gastrointestinal bleeding |
| url | https://www.mdpi.com/1648-9144/59/1/146 |
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