Early Infant Formula Feeding Impacts Urinary Metabolite Profile at 3 Months of Age
There is a growing consensus that nutritional programming may persist and influence risk for several chronic diseases in adulthood. In the present study, we used urinary metabolic analysis in assessing diet effects on early-life metabolism. Urine samples from healthy three-month-old infants fed huma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/11/3552 |
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| author | Fernanda Rosa Kelly E. Mercer Haixia Lin Clark R. Sims Lindsay M. Pack Grace Goode Thomas Badger Aline Andres Laxmi Yeruva |
| author_facet | Fernanda Rosa Kelly E. Mercer Haixia Lin Clark R. Sims Lindsay M. Pack Grace Goode Thomas Badger Aline Andres Laxmi Yeruva |
| author_sort | Fernanda Rosa |
| collection | DOAJ |
| description | There is a growing consensus that nutritional programming may persist and influence risk for several chronic diseases in adulthood. In the present study, we used urinary metabolic analysis in assessing diet effects on early-life metabolism. Urine samples from healthy three-month-old infants fed human milk (HM; <i>n</i> = 93), cow’s milk-based infant formula [MF; <i>n</i> = 80], or soy protein-based infant formula (SF; <i>n</i> = 76) were analyzed with an untargeted metabolomics approach using GC-TOF MS. PLS-DA and ANOVA analyses were performed using MetaboAnalyst (v4.0). A total of 150 metabolites differed significantly among the feeding groups, including dietary-specific patterns of urinary metabolites of sugars, sugar alcohols, amino acids, and polyphenols. Urinary metabolites may mirror the infant’s overall metabolism and serve as a noninvasive tool to examine the neonatal effects of diet on early-infant metabolism. |
| first_indexed | 2024-03-10T14:43:01Z |
| format | Article |
| id | doaj.art-8b0f5f72fc474715a42235092a5543dc |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:43:01Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8b0f5f72fc474715a42235092a5543dc2023-11-20T21:39:10ZengMDPI AGNutrients2072-66432020-11-011211355210.3390/nu12113552Early Infant Formula Feeding Impacts Urinary Metabolite Profile at 3 Months of AgeFernanda Rosa0Kelly E. Mercer1Haixia Lin2Clark R. Sims3Lindsay M. Pack4Grace Goode5Thomas Badger6Aline Andres7Laxmi Yeruva8Arkansas Children’s Nutrition Center, Little Rock, AR 72202, USAArkansas Children’s Nutrition Center, Little Rock, AR 72202, USAArkansas Children’s Nutrition Center, Little Rock, AR 72202, USAArkansas Children’s Nutrition Center, Little Rock, AR 72202, USAArkansas Children’s Nutrition Center, Little Rock, AR 72202, USAArkansas Children’s Nutrition Center, Little Rock, AR 72202, USAArkansas Children’s Nutrition Center, Little Rock, AR 72202, USAArkansas Children’s Nutrition Center, Little Rock, AR 72202, USAArkansas Children’s Nutrition Center, Little Rock, AR 72202, USAThere is a growing consensus that nutritional programming may persist and influence risk for several chronic diseases in adulthood. In the present study, we used urinary metabolic analysis in assessing diet effects on early-life metabolism. Urine samples from healthy three-month-old infants fed human milk (HM; <i>n</i> = 93), cow’s milk-based infant formula [MF; <i>n</i> = 80], or soy protein-based infant formula (SF; <i>n</i> = 76) were analyzed with an untargeted metabolomics approach using GC-TOF MS. PLS-DA and ANOVA analyses were performed using MetaboAnalyst (v4.0). A total of 150 metabolites differed significantly among the feeding groups, including dietary-specific patterns of urinary metabolites of sugars, sugar alcohols, amino acids, and polyphenols. Urinary metabolites may mirror the infant’s overall metabolism and serve as a noninvasive tool to examine the neonatal effects of diet on early-infant metabolism.https://www.mdpi.com/2072-6643/12/11/3552biomarkersbreast milkinfant formulametabolomeurine |
| spellingShingle | Fernanda Rosa Kelly E. Mercer Haixia Lin Clark R. Sims Lindsay M. Pack Grace Goode Thomas Badger Aline Andres Laxmi Yeruva Early Infant Formula Feeding Impacts Urinary Metabolite Profile at 3 Months of Age Nutrients biomarkers breast milk infant formula metabolome urine |
| title | Early Infant Formula Feeding Impacts Urinary Metabolite Profile at 3 Months of Age |
| title_full | Early Infant Formula Feeding Impacts Urinary Metabolite Profile at 3 Months of Age |
| title_fullStr | Early Infant Formula Feeding Impacts Urinary Metabolite Profile at 3 Months of Age |
| title_full_unstemmed | Early Infant Formula Feeding Impacts Urinary Metabolite Profile at 3 Months of Age |
| title_short | Early Infant Formula Feeding Impacts Urinary Metabolite Profile at 3 Months of Age |
| title_sort | early infant formula feeding impacts urinary metabolite profile at 3 months of age |
| topic | biomarkers breast milk infant formula metabolome urine |
| url | https://www.mdpi.com/2072-6643/12/11/3552 |
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