Consumption of Dietary Fiber with Different Physicochemical Properties during Late Pregnancy Alters the Gut Microbiota and Relieves Constipation in Sow Model
Constipation is a common problem in sows and women during late pregnancy. Dietary fiber has potential in the regulation of intestinal microbiota, thereby promoting intestinal motility and reducing constipation. However, the effects of fibers with different physicochemical properties on intestinal mi...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/12/2511 |
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| author | Dongdong Lu Yu Pi Hao Ye Yujun Wu Yu Bai Shuai Lian Dandan Han Dongjiao Ni Xinhua Zou Jinbiao Zhao Shuai Zhang Bas Kemp Nicoline Soede Junjun Wang |
| author_facet | Dongdong Lu Yu Pi Hao Ye Yujun Wu Yu Bai Shuai Lian Dandan Han Dongjiao Ni Xinhua Zou Jinbiao Zhao Shuai Zhang Bas Kemp Nicoline Soede Junjun Wang |
| author_sort | Dongdong Lu |
| collection | DOAJ |
| description | Constipation is a common problem in sows and women during late pregnancy. Dietary fiber has potential in the regulation of intestinal microbiota, thereby promoting intestinal motility and reducing constipation. However, the effects of fibers with different physicochemical properties on intestinal microbe and constipation during late pregnancy have not been fully explored. In this study, a total of 80 sows were randomly allocated to control and one of three dietary fiber treatments from day 85 of gestation to delivery: LIG (lignocellulose), PRS (resistant starch), and KON (konjaku flour). Results showed that the defecation frequency and fecal consistency scores were highest in PRS. PRS and KON significantly increased the level of gut motility regulatory factors, 5-hydroxytryptamine (5-HT), motilin (MTL), and acetylcholinesterase (AChE) in serum. Moreover, PRS and KON promoted the IL-10 level and reduced the TNF-α level in serum. Furthermore, maternal PRS and KON supplementation significantly reduced the number of stillborn piglets. Microbial sequencing analysis showed that PRS and KON increased short-chain fatty acids (SCFAs)-producing genera <i>Bacteroides</i> and <i>Parabacteroides</i> and decreased the abundance of endotoxin-producing bacteria <i>Desulfovibrio</i> and <i>Oscillibacter</i> in feces. Moreover, the relative abundance of <i>Turicibacter</i> and the fecal butyrate concentration in PRS were the highest. Correlation analysis further revealed that the defecation frequency and serum 5-HT were positively correlated with <i>Turicibacter</i> and butyrate. In conclusion, PRS is the best fiber source for promoting gut motility, which was associated with increased levels of 5-HT under specific bacteria <i>Turicibacter</i> and butyrate stimulation, thereby relieving constipation. Our findings provide a reference for dietary fiber selection to improve intestinal motility in late pregnant mothers. |
| first_indexed | 2024-03-09T22:49:31Z |
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| id | doaj.art-8b0fbff79f8c4a06957c577824975076 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:49:31Z |
| publishDate | 2022-06-01 |
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| spelling | doaj.art-8b0fbff79f8c4a06957c5778249750762023-11-23T18:22:25ZengMDPI AGNutrients2072-66432022-06-011412251110.3390/nu14122511Consumption of Dietary Fiber with Different Physicochemical Properties during Late Pregnancy Alters the Gut Microbiota and Relieves Constipation in Sow ModelDongdong Lu0Yu Pi1Hao Ye2Yujun Wu3Yu Bai4Shuai Lian5Dandan Han6Dongjiao Ni7Xinhua Zou8Jinbiao Zhao9Shuai Zhang10Bas Kemp11Nicoline Soede12Junjun Wang13State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaAdaptation Physiology Group, Department of Animal Sciences, Wageningen University, 6700 AH Wageningen, The NetherlandsState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Biological Feed, Ministry of Agriculture and Rural Affairs, Boen Biotechnology Co., Ltd., Ganzhou 341000, ChinaKey Laboratory of Biological Feed, Ministry of Agriculture and Rural Affairs, Boen Biotechnology Co., Ltd., Ganzhou 341000, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaAdaptation Physiology Group, Department of Animal Sciences, Wageningen University, 6700 AH Wageningen, The NetherlandsAdaptation Physiology Group, Department of Animal Sciences, Wageningen University, 6700 AH Wageningen, The NetherlandsState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaConstipation is a common problem in sows and women during late pregnancy. Dietary fiber has potential in the regulation of intestinal microbiota, thereby promoting intestinal motility and reducing constipation. However, the effects of fibers with different physicochemical properties on intestinal microbe and constipation during late pregnancy have not been fully explored. In this study, a total of 80 sows were randomly allocated to control and one of three dietary fiber treatments from day 85 of gestation to delivery: LIG (lignocellulose), PRS (resistant starch), and KON (konjaku flour). Results showed that the defecation frequency and fecal consistency scores were highest in PRS. PRS and KON significantly increased the level of gut motility regulatory factors, 5-hydroxytryptamine (5-HT), motilin (MTL), and acetylcholinesterase (AChE) in serum. Moreover, PRS and KON promoted the IL-10 level and reduced the TNF-α level in serum. Furthermore, maternal PRS and KON supplementation significantly reduced the number of stillborn piglets. Microbial sequencing analysis showed that PRS and KON increased short-chain fatty acids (SCFAs)-producing genera <i>Bacteroides</i> and <i>Parabacteroides</i> and decreased the abundance of endotoxin-producing bacteria <i>Desulfovibrio</i> and <i>Oscillibacter</i> in feces. Moreover, the relative abundance of <i>Turicibacter</i> and the fecal butyrate concentration in PRS were the highest. Correlation analysis further revealed that the defecation frequency and serum 5-HT were positively correlated with <i>Turicibacter</i> and butyrate. In conclusion, PRS is the best fiber source for promoting gut motility, which was associated with increased levels of 5-HT under specific bacteria <i>Turicibacter</i> and butyrate stimulation, thereby relieving constipation. Our findings provide a reference for dietary fiber selection to improve intestinal motility in late pregnant mothers.https://www.mdpi.com/2072-6643/14/12/2511defecation frequencydietary fiberdifferent physicochemical propertieslate pregnancyintestinal motility<i>Turicibacter</i> |
| spellingShingle | Dongdong Lu Yu Pi Hao Ye Yujun Wu Yu Bai Shuai Lian Dandan Han Dongjiao Ni Xinhua Zou Jinbiao Zhao Shuai Zhang Bas Kemp Nicoline Soede Junjun Wang Consumption of Dietary Fiber with Different Physicochemical Properties during Late Pregnancy Alters the Gut Microbiota and Relieves Constipation in Sow Model Nutrients defecation frequency dietary fiber different physicochemical properties late pregnancy intestinal motility <i>Turicibacter</i> |
| title | Consumption of Dietary Fiber with Different Physicochemical Properties during Late Pregnancy Alters the Gut Microbiota and Relieves Constipation in Sow Model |
| title_full | Consumption of Dietary Fiber with Different Physicochemical Properties during Late Pregnancy Alters the Gut Microbiota and Relieves Constipation in Sow Model |
| title_fullStr | Consumption of Dietary Fiber with Different Physicochemical Properties during Late Pregnancy Alters the Gut Microbiota and Relieves Constipation in Sow Model |
| title_full_unstemmed | Consumption of Dietary Fiber with Different Physicochemical Properties during Late Pregnancy Alters the Gut Microbiota and Relieves Constipation in Sow Model |
| title_short | Consumption of Dietary Fiber with Different Physicochemical Properties during Late Pregnancy Alters the Gut Microbiota and Relieves Constipation in Sow Model |
| title_sort | consumption of dietary fiber with different physicochemical properties during late pregnancy alters the gut microbiota and relieves constipation in sow model |
| topic | defecation frequency dietary fiber different physicochemical properties late pregnancy intestinal motility <i>Turicibacter</i> |
| url | https://www.mdpi.com/2072-6643/14/12/2511 |
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