2′-O-Galloylhyperin Isolated From Pyrola incarnata Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the NF-κB Pathways in Vitro and Vivo

2′-O-Galloylhyperin Isolated From Pyrola incarnata Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the NF-κB Pathways in Vitro and Vivo

2′-O-galloylhyperin, a major compound of Pyrola incarnata Fisch., possesses a variety of biological and pharmacological activities, including anti-oxidative and anti-inflammatory activities. Nevertheless, the underlying molecular mechanisms of 2′-O-GH in microbial infection and sepsis are not clear....

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Bibliographic Details
Main Authors: Peng Wang, Chang Gao, Na Guo, Sun-Dong Zhang, Wei Wang, Li-Ping Yao, Jing Zhang, Thomas Efferth, Yu-Jie Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
NF-κB
SIRT1
anti-inflammation
2′-O-galloylhyperin
Nrf2
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00679/full

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