Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats
Abstract In this study, the fraction extracted from turmeric powder with 50% ethanol and fractionated with n-hexane were administered to diet-induced NASH model rats. NASH model was prepared with SD rats by feeding an originally designed choline-deficient, high-fat, high-fructose (HFF-CD) diet for 1...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-47097-6 |
| _version_ | 1797452861049667584 |
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| author | Yukari Watanabe Hitoshi Watanabe Sarasa Kogure Yuri Tanioka Jun Yamauchi Tadasu Furusho |
| author_facet | Yukari Watanabe Hitoshi Watanabe Sarasa Kogure Yuri Tanioka Jun Yamauchi Tadasu Furusho |
| author_sort | Yukari Watanabe |
| collection | DOAJ |
| description | Abstract In this study, the fraction extracted from turmeric powder with 50% ethanol and fractionated with n-hexane were administered to diet-induced NASH model rats. NASH model was prepared with SD rats by feeding an originally designed choline-deficient, high-fat, high-fructose (HFF-CD) diet for 10 weeks. To the HFF-CD diet, hexane fraction and 50% ethanol fraction after hexane fractionation were added at 100 mg/kg body weight. 10 weeks later, blood samples and liver were collected for the following parameters: lipid weights, serum ALT, AST, TG, liver TG, TBARS levels, lipid metabolism-related gene expression and histopathological examination of the liver. As the results, the hexane fraction and 50% ethanol fraction showed a decrease in lipid weight, a decrease in hepatic TG, and activation of PPAR-α in the lipid metabolism-related gene test. These results suggest that the hexane fraction of turmeric has an inhibitory effect on fat accumulation in the liver by promoting lipid metabolism in NASH model rats. |
| first_indexed | 2024-03-09T15:14:46Z |
| format | Article |
| id | doaj.art-8b14def181ea42c8bff0c547b7e1280c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:14:46Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8b14def181ea42c8bff0c547b7e1280c2023-11-26T13:08:40ZengNature PortfolioScientific Reports2045-23222023-11-0113111110.1038/s41598-023-47097-6Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model ratsYukari Watanabe0Hitoshi Watanabe1Sarasa Kogure2Yuri Tanioka3Jun Yamauchi4Tadasu Furusho5Department of Ecological Symbiotic Science, Graduate School of Agriculture, Tokyo University of AgricultureDepartment of International Food and Agricultural Science, Faculty of International Agriculture and Food Studies, Graduate School of Agriculture, Tokyo University of AgricultureDepartment of International Food and Agricultural Science, Faculty of International Agriculture and Food Studies, Tokyo University of AgricultureDepartment of Ecological Symbiotic Science, Graduate School of Agriculture, Tokyo University of AgricultureDepartment of International Food and Agricultural Science, Faculty of International Agriculture and Food Studies, Graduate School of Agriculture, Tokyo University of AgricultureDepartment of Ecological Symbiotic Science, Graduate School of Agriculture, Tokyo University of AgricultureAbstract In this study, the fraction extracted from turmeric powder with 50% ethanol and fractionated with n-hexane were administered to diet-induced NASH model rats. NASH model was prepared with SD rats by feeding an originally designed choline-deficient, high-fat, high-fructose (HFF-CD) diet for 10 weeks. To the HFF-CD diet, hexane fraction and 50% ethanol fraction after hexane fractionation were added at 100 mg/kg body weight. 10 weeks later, blood samples and liver were collected for the following parameters: lipid weights, serum ALT, AST, TG, liver TG, TBARS levels, lipid metabolism-related gene expression and histopathological examination of the liver. As the results, the hexane fraction and 50% ethanol fraction showed a decrease in lipid weight, a decrease in hepatic TG, and activation of PPAR-α in the lipid metabolism-related gene test. These results suggest that the hexane fraction of turmeric has an inhibitory effect on fat accumulation in the liver by promoting lipid metabolism in NASH model rats.https://doi.org/10.1038/s41598-023-47097-6 |
| spellingShingle | Yukari Watanabe Hitoshi Watanabe Sarasa Kogure Yuri Tanioka Jun Yamauchi Tadasu Furusho Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats Scientific Reports |
| title | Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats |
| title_full | Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats |
| title_fullStr | Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats |
| title_full_unstemmed | Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats |
| title_short | Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats |
| title_sort | essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet induced nash model rats |
| url | https://doi.org/10.1038/s41598-023-47097-6 |
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