Synergistic Effects of Omeprazole and Metformin on Glycemic Control in Type 2 Diabetic Patients. A Randomized Clinical Study
Objective: To evaluate the synergistic effects of omeprazole and metformin on glycemic control among patients with type 2 diabetes. Method: This randomized interventional clinical study was conducted in the Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute, Jinna...
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| Format: | Article |
| Language: | English |
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Dow University of Health Sciences
2017-04-01
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| Series: | Journal of the Dow University of Health Sciences |
| Subjects: | |
| Online Access: | http://www.jduhs.com/index.php/jduhs/article/view/455 |
| _version_ | 1818870124346605568 |
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| author | Fizzah Ali Moosa Khan Kausar Aamir Muhammad Azhar Mughal |
| author_facet | Fizzah Ali Moosa Khan Kausar Aamir Muhammad Azhar Mughal |
| author_sort | Fizzah Ali |
| collection | DOAJ |
| description | Objective:
To evaluate the synergistic effects of omeprazole and metformin on glycemic control among patients with type 2 diabetes.
Method:
This randomized interventional clinical study was conducted in the Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute, Jinnah post graduate medical Centre Karachi. Total study period was 10 months (august 2014-June2015) with individual study period of 3 months (90 days), Eighty(80) type 2 diabetic patients (40 in each group) of either sex, ages ranged from 30 to 60 years without any known comorbidities were included. Group-A was treated with metformin alone and Group-B was treated with metformin plus omeprazole. Efficacy was evaluated by means of FBG, and HbA1C.
Results:
Out of 80 patients, 74 had completed the study. Group B showed significant reduction (P=0.001) in terms of FBS and HbA1c level when comparison was done on day 90 with Group A and within group as compared to day 0.
Conclusion:
Addition of proton pump inhibitor with metformin was found effective in achieving better glycemic control in type 2 diabetic patients. |
| first_indexed | 2024-12-19T12:02:02Z |
| format | Article |
| id | doaj.art-8b1672961ad048a4934246ba3e7b56f1 |
| institution | Directory Open Access Journal |
| issn | 1995-2198 2410-2180 |
| language | English |
| last_indexed | 2024-12-19T12:02:02Z |
| publishDate | 2017-04-01 |
| publisher | Dow University of Health Sciences |
| record_format | Article |
| series | Journal of the Dow University of Health Sciences |
| spelling | doaj.art-8b1672961ad048a4934246ba3e7b56f12022-12-21T20:22:28ZengDow University of Health SciencesJournal of the Dow University of Health Sciences1995-21982410-21802017-04-01111242810.36570/jduhs.2017.1.454455Synergistic Effects of Omeprazole and Metformin on Glycemic Control in Type 2 Diabetic Patients. A Randomized Clinical StudyFizzah Ali0Moosa Khan1Kausar Aamir2Muhammad Azhar Mughal3Department of Pharmacology & Therapeutics, Basic Medical Sciences Institute Jinnah Postgraduate Medical Centre Karachi, PakistanBasic Medical Sciences Institute Jinnah Postgraduate Medical Centre Karachi, PakistanDepartment of Pharmacology & Therapeutics, Basic Medical Sciences Institute Jinnah Postgraduate Medical Centre Karachi, PakistanBasic Medical Sciences Institute Jinnah Postgraduate Medical Centre Karachi, PakistanObjective: To evaluate the synergistic effects of omeprazole and metformin on glycemic control among patients with type 2 diabetes. Method: This randomized interventional clinical study was conducted in the Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute, Jinnah post graduate medical Centre Karachi. Total study period was 10 months (august 2014-June2015) with individual study period of 3 months (90 days), Eighty(80) type 2 diabetic patients (40 in each group) of either sex, ages ranged from 30 to 60 years without any known comorbidities were included. Group-A was treated with metformin alone and Group-B was treated with metformin plus omeprazole. Efficacy was evaluated by means of FBG, and HbA1C. Results: Out of 80 patients, 74 had completed the study. Group B showed significant reduction (P=0.001) in terms of FBS and HbA1c level when comparison was done on day 90 with Group A and within group as compared to day 0. Conclusion: Addition of proton pump inhibitor with metformin was found effective in achieving better glycemic control in type 2 diabetic patients.http://www.jduhs.com/index.php/jduhs/article/view/455proton pump inhibitoromeprazolemetforminhba1cfbgsgpt |
| spellingShingle | Fizzah Ali Moosa Khan Kausar Aamir Muhammad Azhar Mughal Synergistic Effects of Omeprazole and Metformin on Glycemic Control in Type 2 Diabetic Patients. A Randomized Clinical Study Journal of the Dow University of Health Sciences proton pump inhibitor omeprazole metformin hba1c fbg sgpt |
| title | Synergistic Effects of Omeprazole and Metformin on Glycemic Control in Type 2 Diabetic Patients. A Randomized Clinical Study |
| title_full | Synergistic Effects of Omeprazole and Metformin on Glycemic Control in Type 2 Diabetic Patients. A Randomized Clinical Study |
| title_fullStr | Synergistic Effects of Omeprazole and Metformin on Glycemic Control in Type 2 Diabetic Patients. A Randomized Clinical Study |
| title_full_unstemmed | Synergistic Effects of Omeprazole and Metformin on Glycemic Control in Type 2 Diabetic Patients. A Randomized Clinical Study |
| title_short | Synergistic Effects of Omeprazole and Metformin on Glycemic Control in Type 2 Diabetic Patients. A Randomized Clinical Study |
| title_sort | synergistic effects of omeprazole and metformin on glycemic control in type 2 diabetic patients a randomized clinical study |
| topic | proton pump inhibitor omeprazole metformin hba1c fbg sgpt |
| url | http://www.jduhs.com/index.php/jduhs/article/view/455 |
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