Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach
Cancer immunotherapy moderates the immune system’s ability to fight cancer. Due to its extreme complexity, scientists are working to put together all the puzzle pieces to get a clearer picture of the immune system. Shreds of available evidence show the connection between cancer and the immune system...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/9/1493 |
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| author | Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Arunraj Namachivayam Reshma Murali D. S. Prabakaran Raja Ganesan Kaviyarasi Renu Abhijit Dey Balachandar Vellingiri Gnanasambandan Ramanathan George Priya Doss C. Abilash Valsala Gopalakrishnan |
| author_facet | Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Arunraj Namachivayam Reshma Murali D. S. Prabakaran Raja Ganesan Kaviyarasi Renu Abhijit Dey Balachandar Vellingiri Gnanasambandan Ramanathan George Priya Doss C. Abilash Valsala Gopalakrishnan |
| author_sort | Anirban Goutam Mukherjee |
| collection | DOAJ |
| description | Cancer immunotherapy moderates the immune system’s ability to fight cancer. Due to its extreme complexity, scientists are working to put together all the puzzle pieces to get a clearer picture of the immune system. Shreds of available evidence show the connection between cancer and the immune system. Immune responses to tumors and lymphoid malignancies are influenced by B cells, γδT cells, NK cells, and dendritic cells (DCs). Cancer immunotherapy, which encompasses adoptive cancer therapy, monoclonal antibodies (mAbs), immune checkpoint therapy, and CART cells, has revolutionized contemporary cancer treatment. This article reviews recent developments in immune cell regulation and cancer immunotherapy. Various options are available to treat many diseases, particularly cancer, due to the progress in various immunotherapies, such as monoclonal antibodies, recombinant proteins, vaccinations (both preventative and curative), cellular immunotherapies, and cytokines. |
| first_indexed | 2024-03-09T22:16:24Z |
| format | Article |
| id | doaj.art-8b191c8a52bc4c7d918b3f2cf6b4ab19 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T22:16:24Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-8b191c8a52bc4c7d918b3f2cf6b4ab192023-11-23T19:22:04ZengMDPI AGVaccines2076-393X2022-09-01109149310.3390/vaccines10091493Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic ApproachAnirban Goutam Mukherjee0Uddesh Ramesh Wanjari1Arunraj Namachivayam2Reshma Murali3D. S. Prabakaran4Raja Ganesan5Kaviyarasi Renu6Abhijit Dey7Balachandar Vellingiri8Gnanasambandan Ramanathan9George Priya Doss C.10Abilash Valsala Gopalakrishnan11Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Radiation Oncology, College of Medicine, Chungbuk National University, Chungdae-ro 1, Seowon-gu, Cheongju 28644, KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon 24252, KoreaCentre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, IndiaDepartment of Life Sciences, Presidency University, Kolkata 700073, West Bengal, IndiaHuman Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Integrative Biology, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaCancer immunotherapy moderates the immune system’s ability to fight cancer. Due to its extreme complexity, scientists are working to put together all the puzzle pieces to get a clearer picture of the immune system. Shreds of available evidence show the connection between cancer and the immune system. Immune responses to tumors and lymphoid malignancies are influenced by B cells, γδT cells, NK cells, and dendritic cells (DCs). Cancer immunotherapy, which encompasses adoptive cancer therapy, monoclonal antibodies (mAbs), immune checkpoint therapy, and CART cells, has revolutionized contemporary cancer treatment. This article reviews recent developments in immune cell regulation and cancer immunotherapy. Various options are available to treat many diseases, particularly cancer, due to the progress in various immunotherapies, such as monoclonal antibodies, recombinant proteins, vaccinations (both preventative and curative), cellular immunotherapies, and cytokines.https://www.mdpi.com/2076-393X/10/9/1493cancerimmune cellscheckpointsCART cellmonoclonal Absimmunotherapy |
| spellingShingle | Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Arunraj Namachivayam Reshma Murali D. S. Prabakaran Raja Ganesan Kaviyarasi Renu Abhijit Dey Balachandar Vellingiri Gnanasambandan Ramanathan George Priya Doss C. Abilash Valsala Gopalakrishnan Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach Vaccines cancer immune cells checkpoints CART cell monoclonal Abs immunotherapy |
| title | Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach |
| title_full | Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach |
| title_fullStr | Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach |
| title_full_unstemmed | Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach |
| title_short | Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach |
| title_sort | role of immune cells and receptors in cancer treatment an immunotherapeutic approach |
| topic | cancer immune cells checkpoints CART cell monoclonal Abs immunotherapy |
| url | https://www.mdpi.com/2076-393X/10/9/1493 |
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