Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats
Prostaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process. The non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and consequently prostaglandins synthesis. E...
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| Format: | Article |
| Language: | English |
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University of São Paulo
2010-12-01
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| Series: | Journal of Applied Oral Science |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572010000600016 |
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| author | Ricardo Nogueira Fracon Juliana Mazzonetto Teófilo Izabela Cristina Moris Teresa Lamano |
| author_facet | Ricardo Nogueira Fracon Juliana Mazzonetto Teófilo Izabela Cristina Moris Teresa Lamano |
| author_sort | Ricardo Nogueira Fracon |
| collection | DOAJ |
| description | Prostaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process. The non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and consequently prostaglandins synthesis. Experimental and clinical evidence has indicated a risk for reparative bone formation related to the use of non-selective (COX-1 and COX-2) and COX-2 selective NSAIDs. Ketorolac is a non-selective NSAID which, at low doses, has a preferential COX-1 inhibitory effect and etoricoxib is a new selective COX-2 inhibitor. Although literature data have suggested that ketorolac can interfere negatively with long bone fracture healing, there seems to be no study associating etoricoxib with reparative bone formation. Paracetamol/acetaminophen, one of the first choices for pain control in clinical dentistry, has been considered a weak anti-inflammatory drug, although supposedly capable of inhibiting COX-2 activity in inflammatory sites. OBJECTIVE: The purpose of the present study was to investigate whether paracetamol, ketorolac and etoricoxib can hinder alveolar bone formation, taking the filling of rat extraction socket with newly formed bone as experimental model. MATERIAL AND METHODS: The degree of new bone formation inside the alveolar socket was estimated two weeks after tooth extraction by a differential point-counting method, using an optical microscopy with a digital camera for image capture and histometry software. Differences between groups were analyzed by ANOVA after confirming a normal distribution of sample data. RESULTS AND CONCLUSIONS: Histometric results confirmed that none of the tested drugs had a detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket. |
| first_indexed | 2024-12-23T21:13:57Z |
| format | Article |
| id | doaj.art-8b1a4b7a36ce42ba8888192d8e6aace4 |
| institution | Directory Open Access Journal |
| issn | 1678-7757 1678-7765 |
| language | English |
| last_indexed | 2024-12-23T21:13:57Z |
| publishDate | 2010-12-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Journal of Applied Oral Science |
| spelling | doaj.art-8b1a4b7a36ce42ba8888192d8e6aace42022-12-21T17:30:58ZengUniversity of São PauloJournal of Applied Oral Science1678-77571678-77652010-12-0118663063410.1590/S1678-77572010000600016Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in ratsRicardo Nogueira FraconJuliana Mazzonetto TeófiloIzabela Cristina MorisTeresa LamanoProstaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process. The non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and consequently prostaglandins synthesis. Experimental and clinical evidence has indicated a risk for reparative bone formation related to the use of non-selective (COX-1 and COX-2) and COX-2 selective NSAIDs. Ketorolac is a non-selective NSAID which, at low doses, has a preferential COX-1 inhibitory effect and etoricoxib is a new selective COX-2 inhibitor. Although literature data have suggested that ketorolac can interfere negatively with long bone fracture healing, there seems to be no study associating etoricoxib with reparative bone formation. Paracetamol/acetaminophen, one of the first choices for pain control in clinical dentistry, has been considered a weak anti-inflammatory drug, although supposedly capable of inhibiting COX-2 activity in inflammatory sites. OBJECTIVE: The purpose of the present study was to investigate whether paracetamol, ketorolac and etoricoxib can hinder alveolar bone formation, taking the filling of rat extraction socket with newly formed bone as experimental model. MATERIAL AND METHODS: The degree of new bone formation inside the alveolar socket was estimated two weeks after tooth extraction by a differential point-counting method, using an optical microscopy with a digital camera for image capture and histometry software. Differences between groups were analyzed by ANOVA after confirming a normal distribution of sample data. RESULTS AND CONCLUSIONS: Histometric results confirmed that none of the tested drugs had a detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572010000600016Bone regenerationParacetamolKetorolacCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 1 inhibitorsCyclooxygenase 2 inhibitors |
| spellingShingle | Ricardo Nogueira Fracon Juliana Mazzonetto Teófilo Izabela Cristina Moris Teresa Lamano Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats Journal of Applied Oral Science Bone regeneration Paracetamol Ketorolac Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 1 inhibitors Cyclooxygenase 2 inhibitors |
| title | Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats |
| title_full | Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats |
| title_fullStr | Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats |
| title_full_unstemmed | Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats |
| title_short | Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats |
| title_sort | treatment with paracetamol ketorolac or etoricoxib did not hinder alveolar bone healing a histometric study in rats |
| topic | Bone regeneration Paracetamol Ketorolac Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 1 inhibitors Cyclooxygenase 2 inhibitors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572010000600016 |
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