Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil
Considering the imminence of new SARS-CoV-2 variants and COVID-19 vaccine availability, it is essential to understand the impact of the disease on the most vulnerable groups and those at risk of death from the disease. To this end, the odds ratio (OR) for mortality and hospitalization was calculated...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/9/10/584 |
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| author | Marilaine Colnago Giovana A. Benvenuto Wallace Casaca Rogério G. Negri Eder G. Fernandes José A. Cuminato |
| author_facet | Marilaine Colnago Giovana A. Benvenuto Wallace Casaca Rogério G. Negri Eder G. Fernandes José A. Cuminato |
| author_sort | Marilaine Colnago |
| collection | DOAJ |
| description | Considering the imminence of new SARS-CoV-2 variants and COVID-19 vaccine availability, it is essential to understand the impact of the disease on the most vulnerable groups and those at risk of death from the disease. To this end, the odds ratio (OR) for mortality and hospitalization was calculated for different groups of patients by applying an adjusted logistic regression model based on the following variables of interest: gender, booster vaccination, age group, and comorbidity occurrence. A massive number of data were extracted and compiled from official Brazilian government resources, which include all reported cases of hospitalizations and deaths associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Brazil during the “wave” of the Omicron variant (BA.1 substrain). Males (1.242; 95% CI 1.196–1.290) aged 60–79 (3.348; 95% CI 3.050–3.674) and 80 years or older (5.453; 95% CI 4.966–5.989), and hospitalized patients with comorbidities (1.418; 95% CI 1.355–1.483), were more likely to die. There was a reduction in the risk of death (0.907; 95% CI 0.866–0.951) among patients who had received the third dose of the anti-SARS-CoV-2 vaccine (booster). Additionally, this big data investigation has found statistical evidence that vaccination can support mitigation plans concerning the current scenario of COVID-19 in Brazil since the Omicron variant and its substrains are now prevalent across the entire country. |
| first_indexed | 2024-03-09T20:40:55Z |
| format | Article |
| id | doaj.art-8b1b270a666141548d92ec77566fb4dc |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T20:40:55Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-8b1b270a666141548d92ec77566fb4dc2023-11-23T22:58:15ZengMDPI AGBioengineering2306-53542022-10-0191058410.3390/bioengineering9100584Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in BrazilMarilaine Colnago0Giovana A. Benvenuto1Wallace Casaca2Rogério G. Negri3Eder G. Fernandes4José A. Cuminato5Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, BrazilFaculty of Science and Technology (FCT), São Paulo State University (UNESP), Presidente Prudente 19060-900, BrazilInstitute of Biosciences, Letters and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto 15054-000, BrazilScience and Technology Institute, São Paulo State University (UNESP), São José dos Campos 12247-004, BrazilImmunization Division—Centre of Epidemiology Surveillance of the São Paulo State Health Department, São Paulo 01246-000, BrazilInstitute of Mathematics and Computer Science, São Paulo University (USP), São Carlos 13566-590, BrazilConsidering the imminence of new SARS-CoV-2 variants and COVID-19 vaccine availability, it is essential to understand the impact of the disease on the most vulnerable groups and those at risk of death from the disease. To this end, the odds ratio (OR) for mortality and hospitalization was calculated for different groups of patients by applying an adjusted logistic regression model based on the following variables of interest: gender, booster vaccination, age group, and comorbidity occurrence. A massive number of data were extracted and compiled from official Brazilian government resources, which include all reported cases of hospitalizations and deaths associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Brazil during the “wave” of the Omicron variant (BA.1 substrain). Males (1.242; 95% CI 1.196–1.290) aged 60–79 (3.348; 95% CI 3.050–3.674) and 80 years or older (5.453; 95% CI 4.966–5.989), and hospitalized patients with comorbidities (1.418; 95% CI 1.355–1.483), were more likely to die. There was a reduction in the risk of death (0.907; 95% CI 0.866–0.951) among patients who had received the third dose of the anti-SARS-CoV-2 vaccine (booster). Additionally, this big data investigation has found statistical evidence that vaccination can support mitigation plans concerning the current scenario of COVID-19 in Brazil since the Omicron variant and its substrains are now prevalent across the entire country.https://www.mdpi.com/2306-5354/9/10/584COVID-19mortalityrisk factorshospitalizationOmicron |
| spellingShingle | Marilaine Colnago Giovana A. Benvenuto Wallace Casaca Rogério G. Negri Eder G. Fernandes José A. Cuminato Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil Bioengineering COVID-19 mortality risk factors hospitalization Omicron |
| title | Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil |
| title_full | Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil |
| title_fullStr | Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil |
| title_full_unstemmed | Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil |
| title_short | Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil |
| title_sort | risk factors associated with mortality in hospitalized patients with covid 19 during the omicron wave in brazil |
| topic | COVID-19 mortality risk factors hospitalization Omicron |
| url | https://www.mdpi.com/2306-5354/9/10/584 |
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