Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1
LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, ENST00000508435, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of ENST00000508435 w...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
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| Series: | Cell Adhesion & Migration |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19336918.2021.1921402 |
| _version_ | 1818388786773491712 |
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| author | Luying Li Youping Jin Xue Wang Li Wang Yangbai Sun Yihong Luo Xiaojian Ni Qi Lu Wenbo Wei Xiuling Zhi Jerry Yu Wei Zhu Ping Zhou |
| author_facet | Luying Li Youping Jin Xue Wang Li Wang Yangbai Sun Yihong Luo Xiaojian Ni Qi Lu Wenbo Wei Xiuling Zhi Jerry Yu Wei Zhu Ping Zhou |
| author_sort | Luying Li |
| collection | DOAJ |
| description | LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, ENST00000508435, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of ENST00000508435 was positively correlated with tumor size, lymph node metastasis and HER2. More interesting, overexpression of ENST00000508435 significantly increased cell migration, while specific knockdown led to the opposite. RNA pull-down and RNA immunoprecipitation assays demonstrated that ENST00000508435 could directly bind to FXR1 to promote tumor metastasis. ENST00000508435 and FXR1 were positively correlated. FXR1 was also significantly up-regulated in breast tumors. Taken together, we propose that ENST00000508435 regulates FXR1 to promote breast cancer metastasis. |
| first_indexed | 2024-12-14T04:31:23Z |
| format | Article |
| id | doaj.art-8b1caca5e50d47cba52e9fc7360f2606 |
| institution | Directory Open Access Journal |
| issn | 1933-6918 1933-6926 |
| language | English |
| last_indexed | 2024-12-14T04:31:23Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cell Adhesion & Migration |
| spelling | doaj.art-8b1caca5e50d47cba52e9fc7360f26062022-12-21T23:17:05ZengTaylor & Francis GroupCell Adhesion & Migration1933-69181933-69262021-01-0115114015110.1080/19336918.2021.19214021921402Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1Luying Li0Youping Jin1Xue Wang2Li Wang3Yangbai Sun4Yihong Luo5Xiaojian Ni6Qi Lu7Wenbo Wei8Xiuling Zhi9Jerry Yu10Wei Zhu11Ping Zhou12School of Basic Medical Sciences, Fudan UniversitySchool of Basic Medical Sciences, Fudan UniversitySchool of Basic Medical Sciences, Fudan UniversityFudan UniversityFudan University Shanghai Cancer Center, Shanghai Medical College, Fudan UniversityFudan UniversityFudan UniversitySchool of Basic Medical Sciences, Fudan UniversityFudan UniversitySchool of Basic Medical Sciences, Fudan UniversityUniversity of LouisvilleFudan UniversitySchool of Basic Medical Sciences, Fudan UniversityLncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, ENST00000508435, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of ENST00000508435 was positively correlated with tumor size, lymph node metastasis and HER2. More interesting, overexpression of ENST00000508435 significantly increased cell migration, while specific knockdown led to the opposite. RNA pull-down and RNA immunoprecipitation assays demonstrated that ENST00000508435 could directly bind to FXR1 to promote tumor metastasis. ENST00000508435 and FXR1 were positively correlated. FXR1 was also significantly up-regulated in breast tumors. Taken together, we propose that ENST00000508435 regulates FXR1 to promote breast cancer metastasis.http://dx.doi.org/10.1080/19336918.2021.1921402breast cancerlncrna enst00000508435fxr1migrationmetastasis |
| spellingShingle | Luying Li Youping Jin Xue Wang Li Wang Yangbai Sun Yihong Luo Xiaojian Ni Qi Lu Wenbo Wei Xiuling Zhi Jerry Yu Wei Zhu Ping Zhou Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1 Cell Adhesion & Migration breast cancer lncrna enst00000508435 fxr1 migration metastasis |
| title | Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1 |
| title_full | Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1 |
| title_fullStr | Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1 |
| title_full_unstemmed | Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1 |
| title_short | Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1 |
| title_sort | long noncoding rna enst00000508435 promotes migration of breast cancer via fxr 1 |
| topic | breast cancer lncrna enst00000508435 fxr1 migration metastasis |
| url | http://dx.doi.org/10.1080/19336918.2021.1921402 |
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