Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study

Patients with stroke are known to manifest a decreased cough force, which is associated with an increased risk of aspiration. Specific brain lesions have been linked to impaired reflexive coughing. However, few studies have investigated whether specific stroke lesions are associated with impaired vo...

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Main Authors: Kyoung Bo Lee, Seong Hoon Lim, Geun-Young Park, Sun Im
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Brain Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3425/10/9/627
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author Kyoung Bo Lee
Seong Hoon Lim
Geun-Young Park
Sun Im
author_facet Kyoung Bo Lee
Seong Hoon Lim
Geun-Young Park
Sun Im
author_sort Kyoung Bo Lee
collection DOAJ
description Patients with stroke are known to manifest a decreased cough force, which is associated with an increased risk of aspiration. Specific brain lesions have been linked to impaired reflexive coughing. However, few studies have investigated whether specific stroke lesions are associated with impaired voluntary cough. Here, we studied the effects of stroke lesions on voluntary cough using voxel-based lesion-symptom mapping (VLSM). In this retrospective cross-sectional study, the peak cough flow was measured in patients who complained of weak cough (<i>n</i> = 39) after supratentorial lesions. Brain lesions were visualized via magnetic resonance imaging (MRI) at the onset of stroke. These lesions were studied using VLSM. The VLSM method with non-parametric mapping revealed that lesions in the sub-gyral frontal lobe and superior longitudinal and posterior corona radiata were associated with a weak cough flow. In addition, lesions in the inferior parietal and temporal lobes and both the superior and mid-temporal gyrus were associated with a weak peak cough flow during voluntary coughing. This study identified several brain lesions underlying impaired voluntary cough. The results might be useful in predicting those at risk of poor cough function and may improve the prognosis of patients at increased risk of respiratory complications after a stroke.
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spelling doaj.art-8b1ccad166004770b4f730f7d486a4c92023-11-20T13:18:54ZengMDPI AGBrain Sciences2076-34252020-09-0110962710.3390/brainsci10090627Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational StudyKyoung Bo Lee0Seong Hoon Lim1Geun-Young Park2Sun Im3Department of Rehabilitation Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Rehabilitation Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Rehabilitation Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Rehabilitation Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaPatients with stroke are known to manifest a decreased cough force, which is associated with an increased risk of aspiration. Specific brain lesions have been linked to impaired reflexive coughing. However, few studies have investigated whether specific stroke lesions are associated with impaired voluntary cough. Here, we studied the effects of stroke lesions on voluntary cough using voxel-based lesion-symptom mapping (VLSM). In this retrospective cross-sectional study, the peak cough flow was measured in patients who complained of weak cough (<i>n</i> = 39) after supratentorial lesions. Brain lesions were visualized via magnetic resonance imaging (MRI) at the onset of stroke. These lesions were studied using VLSM. The VLSM method with non-parametric mapping revealed that lesions in the sub-gyral frontal lobe and superior longitudinal and posterior corona radiata were associated with a weak cough flow. In addition, lesions in the inferior parietal and temporal lobes and both the superior and mid-temporal gyrus were associated with a weak peak cough flow during voluntary coughing. This study identified several brain lesions underlying impaired voluntary cough. The results might be useful in predicting those at risk of poor cough function and may improve the prognosis of patients at increased risk of respiratory complications after a stroke.https://www.mdpi.com/2076-3425/10/9/627Coughmechanismspneumoniastrokebrain mapping
spellingShingle Kyoung Bo Lee
Seong Hoon Lim
Geun-Young Park
Sun Im
Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study
Brain Sciences
Cough
mechanisms
pneumonia
stroke
brain mapping
title Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study
title_full Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study
title_fullStr Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study
title_full_unstemmed Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study
title_short Effect of Brain Lesions on Voluntary Cough in Patients with Supratentorial Stroke: An Observational Study
title_sort effect of brain lesions on voluntary cough in patients with supratentorial stroke an observational study
topic Cough
mechanisms
pneumonia
stroke
brain mapping
url https://www.mdpi.com/2076-3425/10/9/627
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