Development and Validation of LC-MS/MS Method for the Determination of 1-Methyl-4-Nitrosopiperazine (MNP) in Multicomponent Products with Rifampicin—Analytical Challenges and Degradation Studies

Development and Validation of LC-MS/MS Method for the Determination of 1-Methyl-4-Nitrosopiperazine (MNP) in Multicomponent Products with Rifampicin—Analytical Challenges and Degradation Studies

Rifampicin is an essential medicine for treating and preventing tuberculosis (TB). TB is a life-threatening infectious disease and its prevention and treatment are public health imperatives. In the time of a global crisis of nitrosamine contamination of medicinal products, patient safety and a reduc...

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Bibliographic Details
Main Authors: Anna B. Witkowska, Aleksandra Wołczyńska, Agnieszka Lis-Cieplak, Elżbieta U. Stolarczyk
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
genotoxic nitrosamines
trace level analysis
impurity profile
tuberculosis (TB) drug
stress study
degradation mechanism
Online Access:https://www.mdpi.com/1420-3049/28/21/7405

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