Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis
Abstract Introduction Blood urea nitrogen (BUN) is a metabolic product validated to be an independent risk factor in the prognosis of several diseases. However, the prognostic value of BUN in patients with infective endocarditis (IE) remains unevaluated. Methods A total of 1371 patients with a diagn...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-09-01
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| Series: | Infectious Diseases and Therapy |
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| Online Access: | https://doi.org/10.1007/s40121-023-00867-1 |
| _version_ | 1797647273422749696 |
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| author | Qi Wang Jia Qiu Jie-leng Huang Mei Jiang Jun-quan Lu Di Wu Xue-biao Wei Dan-qing Yu |
| author_facet | Qi Wang Jia Qiu Jie-leng Huang Mei Jiang Jun-quan Lu Di Wu Xue-biao Wei Dan-qing Yu |
| author_sort | Qi Wang |
| collection | DOAJ |
| description | Abstract Introduction Blood urea nitrogen (BUN) is a metabolic product validated to be an independent risk factor in the prognosis of several diseases. However, the prognostic value of BUN in patients with infective endocarditis (IE) remains unevaluated. Methods A total of 1371 patients with a diagnosis of IE were included and divided into four groups according to BUN (mmol/L) at admission: < 3.5 (n = 343), 3.5–4.8 (n = 343), 4.8–6.8 (n = 341), and ≥ 6.8 (n = 344). Restricted cubic spline was used to assess the association of BUN with in-hospital mortality. Multivariate analysis was performed to identify the independent risk factors for adverse outcomes. Results The in-hospital mortality reached 7.4%, while the 6-month mortality was 9.8%. The restricted cubic spline plot exhibited an approximately linear relationship between BUN and in-hospital mortality. Receiver operating characteristics curve analysis showed that the optimal cut-off of BUN for predicting in-hospital death was 6.8 mmol/L. Kaplan–Meier analysis showed that patients with BUN > 6.8 mmol/L had a higher 6-month mortality than other groups (log rank = 97.9, P < 0.001). Multivariate analysis indicated that BUN > 6.8 mmol/L was an independent predictor indicator for both in-hospital [adjusted odds ratio (aOR) = 2.365, 95% confidence interval (CI) 1.292–4.328, P = 0.005] and 6-month mortality [adjusted hazard ratio (aHR) = 2.171, 95% CI 1.355–3.479, P = 0.001]. Conclusions BUN is suitable for independently predicting short-term mortality in patients with IE. |
| first_indexed | 2024-03-11T15:13:55Z |
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| id | doaj.art-8b1f16c35d664589afb339aca7e09188 |
| institution | Directory Open Access Journal |
| issn | 2193-8229 2193-6382 |
| language | English |
| last_indexed | 2024-03-11T15:13:55Z |
| publishDate | 2023-09-01 |
| publisher | Adis, Springer Healthcare |
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| series | Infectious Diseases and Therapy |
| spelling | doaj.art-8b1f16c35d664589afb339aca7e091882023-10-29T12:31:14ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822023-09-0112102353236610.1007/s40121-023-00867-1Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective EndocarditisQi Wang0Jia Qiu1Jie-leng Huang2Mei Jiang3Jun-quan Lu4Di Wu5Xue-biao Wei6Dan-qing Yu7Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical UniversityDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical UniversityDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical UniversityDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical UniversityDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical UniversityDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical UniversityDepartment of Geriatric Intensive Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical UniversityDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical UniversityAbstract Introduction Blood urea nitrogen (BUN) is a metabolic product validated to be an independent risk factor in the prognosis of several diseases. However, the prognostic value of BUN in patients with infective endocarditis (IE) remains unevaluated. Methods A total of 1371 patients with a diagnosis of IE were included and divided into four groups according to BUN (mmol/L) at admission: < 3.5 (n = 343), 3.5–4.8 (n = 343), 4.8–6.8 (n = 341), and ≥ 6.8 (n = 344). Restricted cubic spline was used to assess the association of BUN with in-hospital mortality. Multivariate analysis was performed to identify the independent risk factors for adverse outcomes. Results The in-hospital mortality reached 7.4%, while the 6-month mortality was 9.8%. The restricted cubic spline plot exhibited an approximately linear relationship between BUN and in-hospital mortality. Receiver operating characteristics curve analysis showed that the optimal cut-off of BUN for predicting in-hospital death was 6.8 mmol/L. Kaplan–Meier analysis showed that patients with BUN > 6.8 mmol/L had a higher 6-month mortality than other groups (log rank = 97.9, P < 0.001). Multivariate analysis indicated that BUN > 6.8 mmol/L was an independent predictor indicator for both in-hospital [adjusted odds ratio (aOR) = 2.365, 95% confidence interval (CI) 1.292–4.328, P = 0.005] and 6-month mortality [adjusted hazard ratio (aHR) = 2.171, 95% CI 1.355–3.479, P = 0.001]. Conclusions BUN is suitable for independently predicting short-term mortality in patients with IE.https://doi.org/10.1007/s40121-023-00867-1Infective endocarditisBlood urea nitrogenPrognosisHyperazotemia |
| spellingShingle | Qi Wang Jia Qiu Jie-leng Huang Mei Jiang Jun-quan Lu Di Wu Xue-biao Wei Dan-qing Yu Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis Infectious Diseases and Therapy Infective endocarditis Blood urea nitrogen Prognosis Hyperazotemia |
| title | Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis |
| title_full | Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis |
| title_fullStr | Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis |
| title_full_unstemmed | Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis |
| title_short | Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis |
| title_sort | prognostic value of blood urea nitrogen for short term mortality in patients with infective endocarditis |
| topic | Infective endocarditis Blood urea nitrogen Prognosis Hyperazotemia |
| url | https://doi.org/10.1007/s40121-023-00867-1 |
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