Association between serum iron and liver transaminases based on a large adult women population
Abstract Background Studies are being focused on the potential roles of iron in various diseases, but remain unclear for the association between serum iron and liver injury, especially in adult women. Methods Based on the National Health and Nutrition Examination Survey, we investigated the relation...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Journal of Health, Population and Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41043-023-00420-3 |
| _version_ | 1797769449130950656 |
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| author | Andong He Zhuoping Zhou Lili Huang Ka Cheuk Yip Jing Chen Ruiling Yan Ruiman Li |
| author_facet | Andong He Zhuoping Zhou Lili Huang Ka Cheuk Yip Jing Chen Ruiling Yan Ruiman Li |
| author_sort | Andong He |
| collection | DOAJ |
| description | Abstract Background Studies are being focused on the potential roles of iron in various diseases, but remain unclear for the association between serum iron and liver injury, especially in adult women. Methods Based on the National Health and Nutrition Examination Survey, we investigated the relationship between serum iron and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) among 19,185 adult women. Results Using weighted multivariate regression analyses, subgroup analyses, and threshold effect analyses, we found that serum iron was independently and positively correlated with ALT and AST. These associations differed in various age or race. Additionally, we found turning points in the curves of the relationship between serum iron and ALT in all women and the non-pregnant women. Using sensitivity analyses, we further found that the associations between serum iron and the liver transaminases remained positive in the non-pregnant women after adjusting for various covariates, but not in pregnant women. Besides, the positive associations between them kept present after excluding the women with high blood pressure, diabetes, and chronic kidney disease. Conclusion The present study indicated a positive association between serum iron and liver transaminases, indicating that serum iron may be a potential biomarker of liver function. |
| first_indexed | 2024-03-12T21:09:08Z |
| format | Article |
| id | doaj.art-8b21d857329b4e8d90c41105ff0a10ba |
| institution | Directory Open Access Journal |
| issn | 2072-1315 |
| language | English |
| last_indexed | 2024-03-12T21:09:08Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Health, Population and Nutrition |
| spelling | doaj.art-8b21d857329b4e8d90c41105ff0a10ba2023-07-30T11:18:25ZengBMCJournal of Health, Population and Nutrition2072-13152023-07-014211910.1186/s41043-023-00420-3Association between serum iron and liver transaminases based on a large adult women populationAndong He0Zhuoping Zhou1Lili Huang2Ka Cheuk Yip3Jing Chen4Ruiling Yan5Ruiman Li6Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan UniversityDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan UniversityDepartment of Obstetrics and Gynecology, The Sixth Affiliated Hospital of Jinan University, Dongguan Eastern Central HospitalDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan UniversityDepartment of Laboratory Medicine, The First Affiliated Hospital of Jinan UniversityDepartment of Fetal Medicine, The First Affiliated Hospital of Jinan UniversityDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan UniversityAbstract Background Studies are being focused on the potential roles of iron in various diseases, but remain unclear for the association between serum iron and liver injury, especially in adult women. Methods Based on the National Health and Nutrition Examination Survey, we investigated the relationship between serum iron and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) among 19,185 adult women. Results Using weighted multivariate regression analyses, subgroup analyses, and threshold effect analyses, we found that serum iron was independently and positively correlated with ALT and AST. These associations differed in various age or race. Additionally, we found turning points in the curves of the relationship between serum iron and ALT in all women and the non-pregnant women. Using sensitivity analyses, we further found that the associations between serum iron and the liver transaminases remained positive in the non-pregnant women after adjusting for various covariates, but not in pregnant women. Besides, the positive associations between them kept present after excluding the women with high blood pressure, diabetes, and chronic kidney disease. Conclusion The present study indicated a positive association between serum iron and liver transaminases, indicating that serum iron may be a potential biomarker of liver function.https://doi.org/10.1186/s41043-023-00420-3IronLiver transaminasesWomenNutrition Surveys |
| spellingShingle | Andong He Zhuoping Zhou Lili Huang Ka Cheuk Yip Jing Chen Ruiling Yan Ruiman Li Association between serum iron and liver transaminases based on a large adult women population Journal of Health, Population and Nutrition Iron Liver transaminases Women Nutrition Surveys |
| title | Association between serum iron and liver transaminases based on a large adult women population |
| title_full | Association between serum iron and liver transaminases based on a large adult women population |
| title_fullStr | Association between serum iron and liver transaminases based on a large adult women population |
| title_full_unstemmed | Association between serum iron and liver transaminases based on a large adult women population |
| title_short | Association between serum iron and liver transaminases based on a large adult women population |
| title_sort | association between serum iron and liver transaminases based on a large adult women population |
| topic | Iron Liver transaminases Women Nutrition Surveys |
| url | https://doi.org/10.1186/s41043-023-00420-3 |
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