Voltammetric Quantification of Anti-Cancer Antibiotic Bleomycin Using an Electrochemically Pretreated and Decorated with Lead Nanoparticles Screen-Printed Sensor
In this paper, we report a highly sensitive voltammetric sensor for the determination of the anti-cancer antibiotic bleomycin (BLM) based on a screen-printed carbon sensor that is electrochemically pretreated and decorated with lead nanoparticles in the sample solution (pSPCE/PbNPs). These sensor su...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/472 |
| _version_ | 1797625630197547008 |
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| author | Jędrzej Kozak Katarzyna Tyszczuk-Rotko Radovan Metelka |
| author_facet | Jędrzej Kozak Katarzyna Tyszczuk-Rotko Radovan Metelka |
| author_sort | Jędrzej Kozak |
| collection | DOAJ |
| description | In this paper, we report a highly sensitive voltammetric sensor for the determination of the anti-cancer antibiotic bleomycin (BLM) based on a screen-printed carbon sensor that is electrochemically pretreated and decorated with lead nanoparticles in the sample solution (pSPCE/PbNPs). These sensor surface manipulations contribute to significant amplification of the analytical signal and improvement of its shape and repeatability. The effect of the electrochemical behavior of BLM on the pSPCE/PbNPs was examined by electrochemical strategies. CV, EIS, and XPS were used to compare the sensor surface modifications. The effects of the type and pH of the supporting electrolyte and the procedure parameters were optimized. The features of the proposed procedure include: (a) very low limits of detection and quantification (2.8 × 10<sup>−11</sup> and 9.3 × 10<sup>−11</sup> M, respectively), (b) linear ranges (1.0 × 10<sup>−10</sup>–2.0 × 10<sup>−9</sup> M and 2.0 × 10<sup>−9</sup>–2.0 × 10<sup>−8</sup> M, and (c) a high sensitivity of 0.32 µA/nM. The electrochemical sensor was successfully applied for the determination of BLM in wastewater and reference material of human urine samples. |
| first_indexed | 2024-03-11T09:59:01Z |
| format | Article |
| id | doaj.art-8b2287ce4824460281567a78b2670743 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:59:01Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8b2287ce4824460281567a78b26707432023-11-16T15:34:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124147210.3390/ijms24010472Voltammetric Quantification of Anti-Cancer Antibiotic Bleomycin Using an Electrochemically Pretreated and Decorated with Lead Nanoparticles Screen-Printed SensorJędrzej Kozak0Katarzyna Tyszczuk-Rotko1Radovan Metelka2Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Skłodowska University, 20-031 Lublin, PolandFaculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Skłodowska University, 20-031 Lublin, PolandDepartment of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, 532 10 Pardubice, Czech RepublicIn this paper, we report a highly sensitive voltammetric sensor for the determination of the anti-cancer antibiotic bleomycin (BLM) based on a screen-printed carbon sensor that is electrochemically pretreated and decorated with lead nanoparticles in the sample solution (pSPCE/PbNPs). These sensor surface manipulations contribute to significant amplification of the analytical signal and improvement of its shape and repeatability. The effect of the electrochemical behavior of BLM on the pSPCE/PbNPs was examined by electrochemical strategies. CV, EIS, and XPS were used to compare the sensor surface modifications. The effects of the type and pH of the supporting electrolyte and the procedure parameters were optimized. The features of the proposed procedure include: (a) very low limits of detection and quantification (2.8 × 10<sup>−11</sup> and 9.3 × 10<sup>−11</sup> M, respectively), (b) linear ranges (1.0 × 10<sup>−10</sup>–2.0 × 10<sup>−9</sup> M and 2.0 × 10<sup>−9</sup>–2.0 × 10<sup>−8</sup> M, and (c) a high sensitivity of 0.32 µA/nM. The electrochemical sensor was successfully applied for the determination of BLM in wastewater and reference material of human urine samples.https://www.mdpi.com/1422-0067/24/1/472electrochemically prepared screen-printed carbon electrodelead nanoparticlesanti-cancer antibioticbleomycinvoltammetryhuman urine and wastewater sample |
| spellingShingle | Jędrzej Kozak Katarzyna Tyszczuk-Rotko Radovan Metelka Voltammetric Quantification of Anti-Cancer Antibiotic Bleomycin Using an Electrochemically Pretreated and Decorated with Lead Nanoparticles Screen-Printed Sensor International Journal of Molecular Sciences electrochemically prepared screen-printed carbon electrode lead nanoparticles anti-cancer antibiotic bleomycin voltammetry human urine and wastewater sample |
| title | Voltammetric Quantification of Anti-Cancer Antibiotic Bleomycin Using an Electrochemically Pretreated and Decorated with Lead Nanoparticles Screen-Printed Sensor |
| title_full | Voltammetric Quantification of Anti-Cancer Antibiotic Bleomycin Using an Electrochemically Pretreated and Decorated with Lead Nanoparticles Screen-Printed Sensor |
| title_fullStr | Voltammetric Quantification of Anti-Cancer Antibiotic Bleomycin Using an Electrochemically Pretreated and Decorated with Lead Nanoparticles Screen-Printed Sensor |
| title_full_unstemmed | Voltammetric Quantification of Anti-Cancer Antibiotic Bleomycin Using an Electrochemically Pretreated and Decorated with Lead Nanoparticles Screen-Printed Sensor |
| title_short | Voltammetric Quantification of Anti-Cancer Antibiotic Bleomycin Using an Electrochemically Pretreated and Decorated with Lead Nanoparticles Screen-Printed Sensor |
| title_sort | voltammetric quantification of anti cancer antibiotic bleomycin using an electrochemically pretreated and decorated with lead nanoparticles screen printed sensor |
| topic | electrochemically prepared screen-printed carbon electrode lead nanoparticles anti-cancer antibiotic bleomycin voltammetry human urine and wastewater sample |
| url | https://www.mdpi.com/1422-0067/24/1/472 |
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