Gut microbiota in women with gestational diabetes mellitus has potential impact on metabolism in pregnant mice and their offspring
Studies have shown that gestational diabetes mellitus (GDM) is closely related to abnormalities in the gut microbiota, and the offspring of these women have an increased risk of diabetes. There is no direct evidence of whether bacteria in women with GDM colonize the intestinal tract of offspring and...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.870422/full |
| _version_ | 1811221074393694208 |
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| author | Shengtang Qin Shengtang Qin Yutong Wang Yutong Wang Shuxian Wang Shuxian Wang Bohan Ning Jing Huai Jing Huai Huixia Yang Huixia Yang |
| author_facet | Shengtang Qin Shengtang Qin Yutong Wang Yutong Wang Shuxian Wang Shuxian Wang Bohan Ning Jing Huai Jing Huai Huixia Yang Huixia Yang |
| author_sort | Shengtang Qin |
| collection | DOAJ |
| description | Studies have shown that gestational diabetes mellitus (GDM) is closely related to abnormalities in the gut microbiota, and the offspring of these women have an increased risk of diabetes. There is no direct evidence of whether bacteria in women with GDM colonize the intestinal tract of offspring and cause hyperglycemia. In this fecal microbiota transplantation (FMT), pregnant mouse model study, two groups of germ-free (GF) mice after FMT showed different colonization patterns of gut microbiota and phenotype. Compared with the control group (healthy-FMT), we found in the GDM-FMT group as a lower relative abundance of Akkermansia and Faecalibacterium; a lower content of short-chain fatty acids and naringenin in feces; an elevated blood glucose; an inflammatory factor expression (TNF-α, CXCL-15, and IL-6), and a hepatic fat deposition. In addition, the influence of the gut microbiota continued in offspring. The gut microbiota of the offspring of GDM-FMT mice was still different from that of the control group as a lower relative abundance of Akkermansia and Parvibacter; and a higher relative abundance of bacteria such as Oscillibacter, Romboutsia, and Harryflintia. In addition, the offspring of GDM-FMT mice had higher body weight and blood glucose levels than the control offspring. |
| first_indexed | 2024-04-12T07:53:17Z |
| format | Article |
| id | doaj.art-8b2433e995b0441a8933e8e194cde25e |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T07:53:17Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-8b2433e995b0441a8933e8e194cde25e2022-12-22T03:41:33ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-08-011310.3389/fmicb.2022.870422870422Gut microbiota in women with gestational diabetes mellitus has potential impact on metabolism in pregnant mice and their offspringShengtang Qin0Shengtang Qin1Yutong Wang2Yutong Wang3Shuxian Wang4Shuxian Wang5Bohan Ning6Jing Huai7Jing Huai8Huixia Yang9Huixia Yang10Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, ChinaBeijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, ChinaBeijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, ChinaBeijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Beijing, ChinaDepartment of Pathology, Peking University First Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, ChinaBeijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, ChinaBeijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Beijing, ChinaStudies have shown that gestational diabetes mellitus (GDM) is closely related to abnormalities in the gut microbiota, and the offspring of these women have an increased risk of diabetes. There is no direct evidence of whether bacteria in women with GDM colonize the intestinal tract of offspring and cause hyperglycemia. In this fecal microbiota transplantation (FMT), pregnant mouse model study, two groups of germ-free (GF) mice after FMT showed different colonization patterns of gut microbiota and phenotype. Compared with the control group (healthy-FMT), we found in the GDM-FMT group as a lower relative abundance of Akkermansia and Faecalibacterium; a lower content of short-chain fatty acids and naringenin in feces; an elevated blood glucose; an inflammatory factor expression (TNF-α, CXCL-15, and IL-6), and a hepatic fat deposition. In addition, the influence of the gut microbiota continued in offspring. The gut microbiota of the offspring of GDM-FMT mice was still different from that of the control group as a lower relative abundance of Akkermansia and Parvibacter; and a higher relative abundance of bacteria such as Oscillibacter, Romboutsia, and Harryflintia. In addition, the offspring of GDM-FMT mice had higher body weight and blood glucose levels than the control offspring.https://www.frontiersin.org/articles/10.3389/fmicb.2022.870422/fullfecal microbiota transplantationgestational diabetes mellitusgerm-free miceoffspringgut microbiotapregnancy |
| spellingShingle | Shengtang Qin Shengtang Qin Yutong Wang Yutong Wang Shuxian Wang Shuxian Wang Bohan Ning Jing Huai Jing Huai Huixia Yang Huixia Yang Gut microbiota in women with gestational diabetes mellitus has potential impact on metabolism in pregnant mice and their offspring Frontiers in Microbiology fecal microbiota transplantation gestational diabetes mellitus germ-free mice offspring gut microbiota pregnancy |
| title | Gut microbiota in women with gestational diabetes mellitus has potential impact on metabolism in pregnant mice and their offspring |
| title_full | Gut microbiota in women with gestational diabetes mellitus has potential impact on metabolism in pregnant mice and their offspring |
| title_fullStr | Gut microbiota in women with gestational diabetes mellitus has potential impact on metabolism in pregnant mice and their offspring |
| title_full_unstemmed | Gut microbiota in women with gestational diabetes mellitus has potential impact on metabolism in pregnant mice and their offspring |
| title_short | Gut microbiota in women with gestational diabetes mellitus has potential impact on metabolism in pregnant mice and their offspring |
| title_sort | gut microbiota in women with gestational diabetes mellitus has potential impact on metabolism in pregnant mice and their offspring |
| topic | fecal microbiota transplantation gestational diabetes mellitus germ-free mice offspring gut microbiota pregnancy |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.870422/full |
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