Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies
Fast Scan Cyclic Voltammetry (FSCV) has been used for decades as a neurochemical tool for in vivo detection of phasic changes in electroactive neurotransmitters in animal models. Recently, multiple research groups have initiated human neurochemical studies using FSCV or demonstrated interest in brin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.728092/full |
| _version_ | 1818402696849260544 |
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| author | Suelen Lucio Boschen James Trevathan Seth A. Hara Anders Asp Anders Asp J. Luis Lujan J. Luis Lujan |
| author_facet | Suelen Lucio Boschen James Trevathan Seth A. Hara Anders Asp Anders Asp J. Luis Lujan J. Luis Lujan |
| author_sort | Suelen Lucio Boschen |
| collection | DOAJ |
| description | Fast Scan Cyclic Voltammetry (FSCV) has been used for decades as a neurochemical tool for in vivo detection of phasic changes in electroactive neurotransmitters in animal models. Recently, multiple research groups have initiated human neurochemical studies using FSCV or demonstrated interest in bringing FSCV into clinical use. However, there remain technical challenges that limit clinical implementation of FSCV by creating barriers to appropriate scientific rigor and patient safety. In order to progress with clinical FSCV, these limitations must be first addressed through (1) appropriate pre-clinical studies to ensure accurate measurement of neurotransmitters and (2) the application of a risk management framework to assess patient safety. The intent of this work is to bring awareness of the current issues associated with FSCV to the scientific, engineering, and clinical communities and encourage them to seek solutions or alternatives that ensure data accuracy, rigor and reproducibility, and patient safety. |
| first_indexed | 2024-12-14T08:12:28Z |
| format | Article |
| id | doaj.art-8b25810dbce24dfcb0e2123d0a2ef390 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-14T08:12:28Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-8b25810dbce24dfcb0e2123d0a2ef3902022-12-21T23:10:03ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-11-011510.3389/fnins.2021.728092728092Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human StudiesSuelen Lucio Boschen0James Trevathan1Seth A. Hara2Anders Asp3Anders Asp4J. Luis Lujan5J. Luis Lujan6Applied Computational Neurophysiology and Neuromodulation Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United StatesDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United StatesDivision of Engineering, Mayo Clinic, Rochester, MN, United StatesApplied Computational Neurophysiology and Neuromodulation Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United StatesMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United StatesApplied Computational Neurophysiology and Neuromodulation Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United StatesDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United StatesFast Scan Cyclic Voltammetry (FSCV) has been used for decades as a neurochemical tool for in vivo detection of phasic changes in electroactive neurotransmitters in animal models. Recently, multiple research groups have initiated human neurochemical studies using FSCV or demonstrated interest in bringing FSCV into clinical use. However, there remain technical challenges that limit clinical implementation of FSCV by creating barriers to appropriate scientific rigor and patient safety. In order to progress with clinical FSCV, these limitations must be first addressed through (1) appropriate pre-clinical studies to ensure accurate measurement of neurotransmitters and (2) the application of a risk management framework to assess patient safety. The intent of this work is to bring awareness of the current issues associated with FSCV to the scientific, engineering, and clinical communities and encourage them to seek solutions or alternatives that ensure data accuracy, rigor and reproducibility, and patient safety.https://www.frontiersin.org/articles/10.3389/fnins.2021.728092/fullclinical neurochemistrydeep brain stimulationfast scan cyclic voltammetryintraoperativeneurochemical signalingneurophysiology |
| spellingShingle | Suelen Lucio Boschen James Trevathan Seth A. Hara Anders Asp Anders Asp J. Luis Lujan J. Luis Lujan Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies Frontiers in Neuroscience clinical neurochemistry deep brain stimulation fast scan cyclic voltammetry intraoperative neurochemical signaling neurophysiology |
| title | Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies |
| title_full | Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies |
| title_fullStr | Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies |
| title_full_unstemmed | Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies |
| title_short | Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies |
| title_sort | defining a path toward the use of fast scan cyclic voltammetry in human studies |
| topic | clinical neurochemistry deep brain stimulation fast scan cyclic voltammetry intraoperative neurochemical signaling neurophysiology |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.728092/full |
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