The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection
Serine incorporator (SERINC) proteins 1–5 (SERINC1-5) are involved in the progression of several diseases. SERINC2-4 are carrier proteins that incorporate the polar amino acid serine into membranes to facilitate the synthesis of phosphatidylserine and sphingolipids. SERINC genes are also differentia...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.856468/full |
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| author | Shaofen Xu Zhichao Zheng Zhichao Zheng Janak L. Pathak Haoyu Cheng Ziliang Zhou Yanping Chen Qiuyu Wu Lijing Wang Lijing Wang Mingtao Zeng Lihong Wu Lihong Wu |
| author_facet | Shaofen Xu Zhichao Zheng Zhichao Zheng Janak L. Pathak Haoyu Cheng Ziliang Zhou Yanping Chen Qiuyu Wu Lijing Wang Lijing Wang Mingtao Zeng Lihong Wu Lihong Wu |
| author_sort | Shaofen Xu |
| collection | DOAJ |
| description | Serine incorporator (SERINC) proteins 1–5 (SERINC1-5) are involved in the progression of several diseases. SERINC2-4 are carrier proteins that incorporate the polar amino acid serine into membranes to facilitate the synthesis of phosphatidylserine and sphingolipids. SERINC genes are also differentially expressed in tumors. Abnormal expression of SERINC proteins occurs in human cancers of the breast, lung, colon, liver, and various glands, as well as in mouse testes. SERINC proteins also affect cleft lip and palate and nerve-related diseases, such as seizure Parkinsonism and borderline personality. Moreover, SERINC proteins have garnered significant interest as retroviral restriction factors, spurring efforts to define their function and elucidate the mechanisms through which they operate when associated with viruses. Human SERINC proteins possess antiviral potential against human immunodeficiency virus (HIV), SARS-COV-2, murine leukemia virus (MLV), equine infectious anemia virus (EIAV), and hepatitis B virus (HBV). Furthermore, the crystal structure is known, and the critical residues of SERINC5 that act against HIV have been identified. In this review, we discuss the most prevalent mechanisms by which SERINC3 and SERINC5 antagonize viruses and focus on the potential therapeutic applications of SERINC5/3 against HIV. |
| first_indexed | 2024-12-13T22:20:28Z |
| format | Article |
| id | doaj.art-8b2653bc013c44a9952647b3e939cec8 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T22:20:28Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-8b2653bc013c44a9952647b3e939cec82022-12-21T23:29:23ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-04-011010.3389/fcell.2022.856468856468The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral InfectionShaofen Xu0Zhichao Zheng1Zhichao Zheng2Janak L. Pathak3Haoyu Cheng4Ziliang Zhou5Yanping Chen6Qiuyu Wu7Lijing Wang8Lijing Wang9Mingtao Zeng10Lihong Wu11Lihong Wu12Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaDepartment of Basic Oral Medicine, Guangzhou Medical University School and Hospital of Stomatology, Guangzhou, ChinaGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaCenter of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United StatesGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaVascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, ChinaCenter of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United StatesGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaDepartment of Basic Oral Medicine, Guangzhou Medical University School and Hospital of Stomatology, Guangzhou, ChinaSerine incorporator (SERINC) proteins 1–5 (SERINC1-5) are involved in the progression of several diseases. SERINC2-4 are carrier proteins that incorporate the polar amino acid serine into membranes to facilitate the synthesis of phosphatidylserine and sphingolipids. SERINC genes are also differentially expressed in tumors. Abnormal expression of SERINC proteins occurs in human cancers of the breast, lung, colon, liver, and various glands, as well as in mouse testes. SERINC proteins also affect cleft lip and palate and nerve-related diseases, such as seizure Parkinsonism and borderline personality. Moreover, SERINC proteins have garnered significant interest as retroviral restriction factors, spurring efforts to define their function and elucidate the mechanisms through which they operate when associated with viruses. Human SERINC proteins possess antiviral potential against human immunodeficiency virus (HIV), SARS-COV-2, murine leukemia virus (MLV), equine infectious anemia virus (EIAV), and hepatitis B virus (HBV). Furthermore, the crystal structure is known, and the critical residues of SERINC5 that act against HIV have been identified. In this review, we discuss the most prevalent mechanisms by which SERINC3 and SERINC5 antagonize viruses and focus on the potential therapeutic applications of SERINC5/3 against HIV.https://www.frontiersin.org/articles/10.3389/fcell.2022.856468/fullSERINCretroviral virusDNA virusHIVCOVID-19influenza virus |
| spellingShingle | Shaofen Xu Zhichao Zheng Zhichao Zheng Janak L. Pathak Haoyu Cheng Ziliang Zhou Yanping Chen Qiuyu Wu Lijing Wang Lijing Wang Mingtao Zeng Lihong Wu Lihong Wu The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection Frontiers in Cell and Developmental Biology SERINC retroviral virus DNA virus HIV COVID-19 influenza virus |
| title | The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection |
| title_full | The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection |
| title_fullStr | The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection |
| title_full_unstemmed | The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection |
| title_short | The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection |
| title_sort | emerging role of the serine incorporator protein family in regulating viral infection |
| topic | SERINC retroviral virus DNA virus HIV COVID-19 influenza virus |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.856468/full |
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