Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR). These reports were followed by the discovery that such steroids may be synthesised not only in peri...

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Bibliographic Details
Main Authors: Delia Belelli, Derk Hogenkamp, Kelvin W. Gee, Jeremy J. Lambert
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Neurobiology of Stress
Subjects:
Allopregnanolone
GABAA receptor
Neurosteroid
Phasic inhibition
Tonic inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289519300591

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